IPP Inhibitors
Actin-binding protein IPP inhibitors are a collection of chemical compounds that target the actin cytoskeleton, impacting the protein's ability to interact with actin filaments and modulate their dynamics. Cytochalasin D and Latrunculin A are potent disruptors of actin polymerization; Cytochalasin D binds to the barbed ends of actin filaments, and Latrunculin A sequesters actin monomers, both of which reduce the ability of Actin-binding protein IPP to bind and organize actin structures. Swinholide A and Chondramide A also impede actin dynamics by severing and capping filaments and inhibiting monomer polymerization, respectively, which diminishes Actin-binding protein IPP's interaction with the actin cytoskeleton. Jasplakinolide and Phalloidin, by stabilizing actin filaments, inadvertently limit Actin-binding protein IPP's role in actin turnover and remodeling.
Additionally, the actin-myosin contraction modulators ML-7, Y-27632, and Blebbistatin indirectly influence Actin-binding protein IPP's function within the cytoskeleton. By inhibiting key kinases like MLCK and ROCK, ML-7 and Y-27632 alter the tensional forces within actin networks, which affects the mechanical context in which Actin-binding protein IPP operates. Blebbistatin's inhibition of myosin II ATPase activity further diminishes actin-myosin interactions, impacting Actin-binding protein IPP's associated activities. Inhibition of actin nucleation and branching by CK 666 and SMIFH2, which target the Arp2/3 complex and formin, respectively, leads to a reduction in filamentous structures necessary for Actin-binding protein IPP's binding and regulatory function, thereby resulting in the attenuation of its activity within the actin cytoskeleton.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Cytochalasin D | 22144-77-0 | sc-201442 sc-201442A | 1 mg 5 mg | $165.00 $486.00 | 64 | |
This compound disrupts actin polymerization by binding to the barbed ends of actin filaments, leading to the inhibition of Actin-binding protein IPP's ability to bind to actin. | ||||||
Latrunculin A, Latrunculia magnifica | 76343-93-6 | sc-202691 sc-202691B | 100 µg 500 µg | $265.00 $815.00 | 36 | |
Sequesters G-actin monomers, preventing their polymerization into F-actin, thereby reducing the availability of actin filaments for Actin-binding protein IPP to interact with. | ||||||
Swinholide A, Theonella swinhoei | 95927-67-6 | sc-205914 | 10 µg | $135.00 | ||
Serves as an actin filament severing and capping agent, which ultimately diminishes the functional activity of Actin-binding protein IPP by reducing the number of binding sites on actin. | ||||||
Jasplakinolide | 102396-24-7 | sc-202191 sc-202191A | 50 µg 100 µg | $184.00 $305.00 | 59 | |
Stabilizes actin filaments and prevents their depolymerization, which can paradoxically inhibit the ability of Actin-binding protein IPP to bind by reducing actin dynamics. | ||||||
Phalloidin | 17466-45-4 | sc-202763 | 1 mg | $234.00 | 33 | |
Stabilizes F-actin and prevents depolymerization, similarly to Jasplakinolide, leading to a decrease in Actin-binding protein IPP's functional interaction with actin due to reduced filament turnover. | ||||||
ML-7 hydrochloride | 110448-33-4 | sc-200557 sc-200557A | 10 mg 50 mg | $91.00 $267.00 | 13 | |
Inhibits myosin light chain kinase (MLCK), which could reduce actin-myosin contraction and thus indirectly affect the functional activity of Actin-binding protein IPP within the actin cytoskeleton. | ||||||
Y-27632, free base | 146986-50-7 | sc-3536 sc-3536A | 5 mg 50 mg | $186.00 $707.00 | 88 | |
Inhibits ROCK (Rho-associated protein kinase), which is involved in actin filament stabilization and contraction, indirectly affecting Actin-binding protein IPP's role in actin dynamics. | ||||||
(S)-(−)-Blebbistatin | 856925-71-8 | sc-204253 sc-204253A sc-204253B sc-204253C | 1 mg 5 mg 10 mg 25 mg | $72.00 $265.00 $495.00 $968.00 | ||
Inhibits myosin II ATPase activity, leading to a reduction in actin-myosin interactions and possibly diminishing the functional role of Actin-binding protein IPP. | ||||||
CK 666 | 442633-00-3 | sc-361151 sc-361151A | 10 mg 50 mg | $321.00 $1040.00 | 5 | |
Inhibits the Arp2/3 complex, which nucleates new actin filaments, thus reducing actin branching and indirectly diminishing the function of Actin-binding protein IPP. | ||||||
SMIFH2 | 340316-62-3 | sc-507273 | 5 mg | $140.00 | ||
Inhibits formin-mediated actin nucleation and elongation, consequently decreasing the available actin filament structures for Actin-binding protein IPP to bind to. | ||||||