Molecular structure of Phalloidin, CAS Number: 17466-45-4
Phalloidin (CAS 17466-45-4)
See product citations (33)
Alternate Names:
Phalloidin is known as a heptapeptide phallotoxin.
Application:
Phalloidin is a heptapeptide phallotoxin and F-actin stabilizing toxin that can prevent the dissociation of paired filaments in the cell.
CAS Number:
17466-45-4
Purity:
≥90%
Molecular Weight:
788.9
Molecular Formula:
C35H48N8O11S
Supplemental Information:
This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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Description
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SDS & Certificate of Analysis
Phalloidin is a heptapeptide phallotoxin produced by Amanita phalloides, the death cap mushroom. Phalloidin binds and stabilizes filamentous F-actin, preventing the dissociation of paired filaments and disturbing the natural equilibrium between filamentous (polymeric) and globular (monomeric) actin in the cell. The actin stabilized by Phalloidin is used by the cell for mechanical processes such as growth, scaffolding of the cytoskeleton, and locomotion, and disruption of this actin equilibrium destroys cellular functioning. Phalloidin can be fluorescently labeled and is used to stain F-actin in cells.
Phalloidin (CAS 17466-45-4) References
- Phalloidin synthetic analogues: structural requirements in the interaction with F-actin. | Falcigno, L., et al. 2001. Chemistry. 7: 4665-73. PMID: 11757659
- Effects of phalloidin on the biliary excretion of cholephilic compounds in rats. | Ohashi, M., et al. 2002. Pharmacology. 66: 31-5. PMID: 12169763
- The effect of phalloidin and jasplakinolide on the flexibility and thermal stability of actin filaments. | Visegrády, B., et al. 2004. FEBS Lett. 565: 163-6. PMID: 15135072
- Effects of phalloidin on hepatic gene expression in mice. | Lim, JS., et al. 2007. Int J Toxicol. 26: 213-20. PMID: 17564902
- Labeling cytoskeletal F-actin with rhodamine phalloidin or fluorescein phalloidin for imaging. | Chazotte, B. 2010. Cold Spring Harb Protoc. 2010: pdb.prot4947. PMID: 20439405
- Phalloidin perturbs the interaction of human non-muscle myosin isoforms 2A and 2C1 with F-actin. | Diensthuber, RP., et al. 2011. FEBS Lett. 585: 767-71. PMID: 21295570
- Structural Effects and Functional Implications of Phalloidin and Jasplakinolide Binding to Actin Filaments. | Pospich, S., et al. 2020. Structure. 28: 437-449.e5. PMID: 32084355
- Effects of cytochalasin and phalloidin on actin. | Cooper, JA. 1987. J Cell Biol. 105: 1473-8. PMID: 3312229
- Comparing lifeact and phalloidin for super-resolution imaging of actin in fixed cells. | Mazloom-Farsibaf, H., et al. 2021. PLoS One. 16: e0246138. PMID: 33508018
- Phalloidin-induced actin polymerization in the cytoplasm of cultured cells interferes with cell locomotion and growth. | Wehland, J., et al. 1977. Proc Natl Acad Sci U S A. 74: 5613-7. PMID: 341163
- Phalloidin fluorescence and confocal microscopy reveal the musculature development of clam Ruditapes philippinarum. | Wu, L., et al. 2022. Comp Biochem Physiol B Biochem Mol Biol. 258: 110693. PMID: 34752895
- Confocal Laser Microscopy for VM Analysis with DAPI and Phalloidin Staining. | Cesca, K. and Oliveira, EM. 2022. Methods Mol Biol. 2514: 153-161. PMID: 35771427
- Toxin screening of Pseudosperma umbrinellum (Agaricals, Basidiomycota): First report of phalloidin in Inocybaceae mushroom. | Zhang, YZ., et al. 2022. Toxicon. 217: 155-161. PMID: 35998714
- Optimized Fixation and Phalloidin Staining of Basally Localized F-Actin Networks in Collectively Migrating Follicle Cells. | Anderson, MT., et al. 2023. Methods Mol Biol. 2626: 179-191. PMID: 36715905
- Localization of the phalloidin and nucleotide-binding sites on actin. | Barden, JA., et al. 1987. Eur J Biochem. 162: 583-8. PMID: 3830158
Inhibitor of:
α-actinin-3, α-centractin, β1-Syntrophin, 4.1R, 4930488E11Rik, 6230427J02Rik, 6720456B07Rik, 7420426K07Rik, ABLIM1, ABLIM2, Abp1, ACT, ACTA1, ACTBL1, ACTC1, ACTG1, ACTL10, ACTL7B, ACTL8, ACTR10, adseverin, AFAP-1L2, ANK-1, APXL, Arp-T2, Arp3β, Astrotactin, BPAG1, CAP1, CapZ-α, CapZ-α1, CapZ-α2, CapZ-α3, Ccdc163, Cofilin 2, Coronin 1C, Coronin 2A, CTTNBP2NL, Cypher, DAAM2, FBP21, FHOD1, Filamin 3, FLJ38973_1700066M21Rik, Formin Like (FMNL1, FMNL2), Gm498, I-Plastin, IPP, Keratin 83, KIAA1407, KLHDC1, KRTAP10-4, KRTAP4-2, Lad, Lamellipodin, Leiomodin1, LIN-10, MORN3, Muscle Actin, MYH13, Myoferlin, Myosin IIIa, Myotilin, NHS, NHSL1, NO145, NYAP1, OR4N5, Otoferlin, palladin, PARV (parvin), Parvin beta, piccolo, POF1B, Profilin-3, Profilin-4, ProSAPiP1, PSD, R-PE, Rab11-FIP2, RBM28, RIM-BP2, Rim1, S-probe, Septin 2, SHD1, SIPA1L, Skn-1i, SNAPC 50, SPACA1, spectrin α, spectrin α I, spectrin αII, spectrin β I, spectrin β II, spectrin β III, spectrin β IV, Spir-2, SYAP1, Synaptopodin, Syncoilin, T-Plastin, Tβ-15a, TCTA, TM4-B, Tmsb15b1, tropomodulin, Tropomyosin β, Tuba, Villin, Vimentin, WDR81, WIRE, Xinα, Xinβ, and zygin 1.Activator of:
4.1R, 4921517D21Rik, 6720456H20Rik, 7420426K07Rik, ACTA1, ACTBL1, ACTG2, ACTL10, ACTL7A, ACTL8, AFAP-110, AIP5, Amnionless, ARHGAP18, Arp3C, Arp7, ARPC5L, Basal bodies, C11orf56, C20orf134, CapZ-α2, CapZ-α3, CapZ-β, CDCrel-1, CDY1, CED-2, Centaurin α1, Clostridium difficile Toxin A, Cordon-bleu, Coronin 1B, Coronin 1C, CR16, CYFIP1, Dia 1, DIAPH3, Dynactin 2, EPLIN, Eps8, epsin, ESPNL, EVL, FAM38B, Fascin 2, FCHSD1, FHOD1, FHOD3, FNBP4, FRMD3, Gas2, Gm498, Gm732, GMF-γ, IBA2, INF2, Kaptin, KLHDC8A, KRAP, Las17, Leiomodin 1, LOC339809, MEIG1, MICALCL, MSE55, Myo2p, Myosin Ia, Myosin IIIb, Myosin VIIa, Myosin XVIIIa, Myosin XVIIIb, Myosin-13, Myosin-XIX, Myosin-XVA, Nebulette, NHS, p21-ARC, pan-Cytokeratin, Paralemmin 3, prefoldin 6, RPL24, RPRC1, SEPT10, Septin 1, Septin 12, SRGAP1, Stereocilin, SWAP-70, Tβ-10, Tmsbl1, TOCA-1, transgelin-2, tropomodulin, tropomodulin 1, tropomodulin 2, tropomodulin 3, tropomodulin 4, Twinfilin-1, and WIP.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Phalloidin, 1 mg | sc-202763 | 1 mg | $229.00 |