INTS7 Inhibitors
INTS7 inhibitors comprise a diverse array of chemical compounds that interfere with various signaling pathways and biological processes to reduce the functional activity of INTS7. Rapamycin, by targeting the mTOR pathway, can disrupt processes critical to INTS7's role in RNA processing, as the mTOR pathway is implicated in the assembly of the integrator complex where INTS7 functions. Similarly, proteasome inhibitors like MG-132 and Lactacystin lead to an accumulation of misfolded proteins, potentially obstructing the integrator complex and thereby diminishing INTS7 activity. Kinase inhibitors such as Staurosporine broadly target kinases that could regulate INTS7 via phosphorylation, affecting its role within the integrator complex, while LY 294002 and Wortmannin specifically inhibit PI3K, destabilizing molecular interactions that may be essential for INTS7's functionality.
Moreover, the MAPK/ERK signaling inhibitors U0126 and PD 98059, as well as JNK inhibitor SP600125 and p38 MAPK inhibitor SB 203580, could alter cellular processes that indirectly modulate INTS7's activity within the integrator complex. The inhibition of Hsp90 by 17-AAG might disrupt the function of proteins that interact with or regulate INTS7, leading to a reduction in its activity. Additionally, ATM Kinase Inhibitor can influence INTS7 by interfering with the cellular response to DNA damage, which may have implications for the stability or activity of the integrator complex involving INTS7. Collectively, these INTS7 inhibitors operate through various mechanisms to indirectly decrease the activity of INTS7 by affecting pathways and processes crucial to its function.
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Items 1 to 10 of 12 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $63.00 $158.00 $326.00 | 233 | |
Rapamycin is an mTOR inhibitor that can indirectly decrease the functional activity of INTS7 by inhibiting the mTOR pathway, which is involved in complex assembly and may be required for INTS7-mediated RNA processing. | ||||||
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $153.00 $396.00 | 113 | |
Staurosporine is a potent inhibitor of protein kinases. By broadly inhibiting kinase activity, it can diminish the phosphorylation state of proteins that may regulate INTS7 function within the integrator complex. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
LY 294002 is a PI3K inhibitor that diminishes PI3K/AKT signaling, which potentially affects the assembly or stability of the INTS7-containing integrator complex, leading to decreased INTS7 functional activity. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $67.00 $223.00 $425.00 | 97 | |
Wortmannin is a PI3K inhibitor that indirectly inhibits INTS7 function by destabilizing integrator complex formations that depend on PI3K/AKT signaling. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $64.00 $246.00 | 136 | |
U0126 is an inhibitor of MEK1/2 which is involved in the MAPK/ERK pathway. Inhibition of this pathway can indirectly influence INTS7 function if INTS7 activity is modulated by MAPK/ERK signaling. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $40.00 $92.00 | 212 | |
PD 98059 is another MEK inhibitor that blocks the MAPK/ERK pathway, potentially affecting INTS7 activity. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
SP600125 is an inhibitor of JNK, part of the MAPK family. JNK inhibition can lead to alterations in cellular processes that may indirectly influence INTS7 function within the integrator complex. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $90.00 $349.00 | 284 | |
SB 203580 is a specific inhibitor of p38 MAPK. The inhibition of p38 MAPK can lead to changes in cellular processes that indirectly affect the activity of INTS7. | ||||||
MG-132 [Z-Leu- Leu-Leu-CHO] | 133407-82-6 | sc-201270 sc-201270A sc-201270B | 5 mg 25 mg 100 mg | $60.00 $265.00 $1000.00 | 163 | |
MG-132 is a proteasome inhibitor that can lead to the accumulation of misfolded proteins, potentially disrupting the proper assembly or function of the INTS7-containing integrator complex. | ||||||
Lactacystin | 133343-34-7 | sc-3575 sc-3575A | 200 µg 1 mg | $188.00 $575.00 | 60 | |
Lactacystin is a proteasome inhibitor which can indirectly inhibit INTS7 by causing the accumulation of proteins that may disrupt integrator complex formation and function. | ||||||