Int-6 Activators
Compounds such as Forskolin and Caffeine elevate intracellular cAMP levels, which in turn activate PKA. This kinase has the potential to phosphorylate translation initiation factors, thereby enhancing the activity of Int-6 within the eIF3 complex. Similarly, Rapamycin and PP242, both mTOR inhibitors, could indirectly upregulate alternative protein synthesis pathways which would conceivably demand a greater functional contribution from Int-6. PI3K inhibitors like LY294002 and Wortmannin could also rebalance the control of protein synthesis, positing an amplified role for Int-6. Additionally, MEK inhibitors PD 98059 and U0126, as well as the p38 MAP kinase inhibitor SB203580, may relieve inhibitory constraints on the translation initiation complex, potentially leading to an augmented function of Int-6.
Moreover, the JNK inhibitor SP600125 and the S6 kinase inhibitor PF-4708671 are involved in adjusting the regulatory mechanisms of protein synthesis, which could reflect in an increased role for Int-6 in this fundamental cellular process. Curcumin, through its multifaceted interactions within the cell, may create a state that necessitates enhanced translation initiation activity, where Int-6's function is critical. These chemical activators, through their targeted effects on various signaling cascades and molecular processes, facilitate an environment conducive to the enhancement of Int-6's role in translation initiation. By influencing specific kinases, phosphatases, and other regulatory proteins, they forge a cellular context that underscores the importance of efficient and controlled protein synthesis, with Int-6 being a pivotal player in this orchestrated cellular symphony. These compounds, while diverse in their initial targets, converge on the shared outcome of bolstering Int-6's participation in one of the most critical aspects of cellular function – the initiation of protein translation.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin activates adenylate cyclase, leading to increased cAMP levels. Elevated cAMP activates PKA, which could enhance protein synthesis by phosphorylating factors involved in the initiation of translation, consequently enhancing Int-6 activity in this process. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $40.00 $92.00 | 212 | |
PD 98059 is a MEK inhibitor that prevents the activation of MAPK/ERK pathway. Int-6 has been linked to the MAPK pathway, and by inhibiting MEK, PD 98059 may relieve inhibitory control on translation initiation factors, indirectly enhancing Int-6 function. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $63.00 $158.00 $326.00 | 233 | |
Rapamycin inhibits mTOR, a central regulator of cell growth and proliferation, which includes protein synthesis. Suppression of mTOR could lead to a compensatory upregulation of other protein synthesis pathways, potentially increasing Int-6-mediated translation. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
LY294002 is a PI3K inhibitor which can modulate signaling pathways upstream of eIF3, including Int-6. By inhibiting PI3K, there can be an altered balance in translation control, potentially enhancing the role of Int-6 in this process. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
SP600125 is a JNK inhibitor, and by inhibiting JNK, it might affect protein synthesis regulation. This alteration could enhance Int-6’s role in translation initiation by modifying the signaling context in which Int-6 operates. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $90.00 $349.00 | 284 | |
SB203580 is a specific inhibitor of p38 MAP kinase. Inhibition of p38 has been linked to altered translation regulation, which may enhance the activity of Int-6 as a component of the eIF3 complex in protein synthesis. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $67.00 $223.00 $425.00 | 97 | |
Wortmannin is a potent PI3K inhibitor, which by modulating PI3K/Akt pathway, could affect protein synthesis. This might result in an indirect enhancement of Int-6’s activity in the translation initiation process. | ||||||
PP242 | 1092351-67-1 | sc-301606A sc-301606 | 1 mg 5 mg | $57.00 $172.00 | 8 | |
PP242 is an mTOR inhibitor, distinct from rapamycin, that broadly inhibits both mTORC1 and mTORC2 complexes. By inhibiting mTOR signaling, PP242 might enhance pathways that compensate for reduced global protein synthesis, possibly involving Int-6. | ||||||
PF 4708671 | 1255517-76-0 | sc-361288 sc-361288A | 10 mg 50 mg | $179.00 $700.00 | 9 | |
PF-4708671 is an inhibitor of the S6 kinase, downstream of mTOR. By inhibiting S6K, this compound might influence the translation initiation complex, potentially enhancing the activity of Int-6 in the process. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Curcumin has multiple cellular targets and has been shown to affect protein synthesis. Its action could lead to a cellular environment that requires enhanced translation initiation activity, potentially involving Int-6. | ||||||