Int-6 Inhibitors

Int-6 (Integration site 6) inhibitors are a class of chemical compounds that primarily target a cellular protein known as Int6 or eIF3e (eukaryotic translation initiation factor 3e). Int6 is a subunit of the eukaryotic translation initiation factor eIF3, which plays a crucial role in protein synthesis, a fundamental cellular process essential for the growth and maintenance of all living organisms. Inhibitors of Int6 function by disrupting its normal activities within the eIF3 complex, leading to significant consequences for cellular protein synthesis regulation and potentially impacting various cellular functions.

The eIF3 complex, in which Int6 is a subunit, is involved in several key steps of translation initiation, including the recruitment of the ribosome to the mRNA (messenger RNA) and the scanning of the ribosome along the mRNA to identify the start codon. Int6, as a part of this complex, contributes to the proper assembly and function of eIF3 during translation initiation. Inhibitors of Int6 are designed to interfere with these functions, either by directly binding to Int6 or by affecting its interaction with other components of the eIF3 complex. This disruption can lead to dysregulated protein synthesis, potentially causing a global impact on cellular protein production, which in turn can influence various cellular processes.