Imp3 Activators
Imp3 Activators are a class of chemical compounds that can enhance the functional activity of Imp3, a protein that plays a crucial role in several cellular processes. These compounds exert their effect either directly or indirectly, by primarily influencing the cellular signaling pathways that Imp3 is involved in. For instance, curcumin and resveratrol are known to impact the TGF-β and PI3K/Akt pathways respectively. As these pathways are known to regulate the activity of Imp3, these compounds, by modulating these pathways, can enhance the functional activity of Imp3.
The other compounds in this class, such as quercetin, also operate through similar mechanisms, influencing pathways like PI3K/Akt where Imp3 is a downstream effector. Certain compounds in this class, such as etoposide, daunorubicin, and doxorubicin, enhance the p53 pathway, which can lead to increased Imp3 activity as Imp3 is a known target of p53. Other compounds like staurosporine and cyclosporine A inhibit PKC, mTOR, calcineurin, and PI3K/Akt pathways respectively, leading to an indirect enhancement of Imp3 activity, as Imp3 is a downstream effector in these pathways.
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Curcumin can inhibit the TGF-β pathway, a pathway that negatively regulates Imp3. By inhibiting TGF-β signaling, curcumin can indirectly enhance the functional activity of Imp3. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Resveratrol enhances the PI3K/Akt pathway. Given that Imp3 is known to be a downstream effector in this signaling cascade, the activation of this pathway can directly lead to increased functional activity of Imp3. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $110.00 $250.00 $936.00 $50.00 | 33 | |
Quercetin enhances the PI3K/Akt pathway, and given that Imp3 is a downstream effector in this pathway, the activation of this pathway can directly lead to increased functional activity of Imp3. | ||||||
Etoposide (VP-16) | 33419-42-0 | sc-3512B sc-3512 sc-3512A | 10 mg 100 mg 500 mg | $51.00 $231.00 $523.00 | 63 | |
Etoposide enhances the p53 pathway. Imp3 is a known target of p53, and thus, the activation of this pathway can lead to increased functional activity of Imp3. | ||||||
Doxorubicin | 23214-92-8 | sc-280681 sc-280681A | 1 mg 5 mg | $176.00 $426.00 | 43 | |
Doxorubicin enhances the p53 pathway. Since Imp3 is a target of p53, the activation of this pathway can lead to increased functional activity of Imp3. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $45.00 $164.00 $200.00 $402.00 $575.00 $981.00 $2031.00 | 46 | |
Genistein enhances the PI3K/Akt pathway. As Imp3 is a downstream effector in this pathway, the activation of this pathway can directly lead to increased functional activity of Imp3. | ||||||
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $153.00 $396.00 | 113 | |
Staurosporine inhibits protein kinase C (PKC). Imp3, being downstream of PKC, can have its functional activity indirectly enhanced when PKC is inhibited by staurosporine. | ||||||
Cyclosporin A | 59865-13-3 | sc-3503 sc-3503-CW sc-3503A sc-3503B sc-3503C sc-3503D | 100 mg 100 mg 500 mg 10 g 25 g 100 g | $63.00 $92.00 $250.00 $485.00 $1035.00 $2141.00 | 69 | |
Cyclosporine A inhibits calcineurin. Given that Imp3 is downstream of calcineurin, the inhibition of this pathway can indirectly lead to the activation of Imp3. | ||||||