Imp3 Inhibitors
Imp3 inhibitors are a class of chemical compounds designed to specifically inhibit the activity of Imp3 (Importin-3), a member of the importin protein family responsible for mediating the transport of macromolecules into the nucleus. Importin-3 plays a crucial role in recognizing cargo proteins with a nuclear localization signal (NLS) and facilitating their movement through the nuclear pore complex, a gateway that regulates the exchange of molecules between the nucleus and cytoplasm. By binding to specific cargoes, Imp3 forms a transport complex that ensures the proper delivery of essential proteins and other molecules into the nucleus, which is vital for maintaining cellular functions such as gene expression and DNA organization. Imp3 inhibitors disrupt this process, preventing the correct nuclear localization of its cargo proteins.
In research settings, Imp3 inhibitors are valuable tools for studying the precise role of Imp3 in nucleocytoplasmic transport and understanding how its inhibition affects nuclear and cellular processes. By blocking the action of Imp3, researchers can explore the consequences of improper protein localization, shedding light on how specific cargo proteins contribute to nuclear functions such as chromatin remodeling, transcriptional regulation, and RNA processing. The inhibition of Imp3 also allows for investigation into the selectivity and specificity of the nuclear import pathway, revealing how Imp3 coordinates with other importins to manage the transport of diverse molecules. Additionally, studying the impact of Imp3 inhibitors on cellular responses to environmental changes or stress conditions helps to deepen the understanding of how nucleocytoplasmic transport is dynamically regulated and how it contributes to overall cellular homeostasis.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002 is a potent inhibitor of phosphoinositide 3-kinases (PI3K), which are involved in the signaling pathways that contribute to the regulation of translation initiation. By inhibiting PI3K, LY294002 can disrupt the downstream signaling that might be necessary for the function of Imp3 in its role of RNA binding and the regulation of translation of target mRNAs. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
Wortmannin is another potent and irreversible inhibitor of PI3K. The inhibition of PI3K can lead to a decrease in the phosphorylation of downstream targets involved in mRNA translation, potentially impairing the functional role of Imp3 in these processes. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $62.00 $155.00 $320.00 | 233 | |
Rapamycin specifically inhibits mTOR (mammalian target of rapamycin), which is part of the mTORC1 complex, a key regulator of protein synthesis and cell growth. Inhibition of mTORC1 can downregulate the pathways Imp3 is involved in, specifically those related to mRNA translation and cell proliferation. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
PD98059 is a selective inhibitor of MEK, which works upstream of ERK in the MAPK/ERK pathway. Since this pathway can influence protein translation, inhibiting MEK could impact the ability of Imp3 to regulate the translation of its mRNA targets. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $63.00 $241.00 | 136 | |
U0126 is a well-known inhibitor of MEK1/2, which prevents the activation of ERK1/2. By inhibiting this pathway, U0126 can reduce the mRNA translation activity where Imp3 is known to be involved, thereby functionally inhibiting the protein. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
SB203580 selectively inhibits p38 MAP kinase, which is implicated in controlling the translation of specific mRNAs. Inhibition of p38 MAP kinase can thus affect the pathways that regulate mRNA stability and translation, where Imp3 might play a critical role. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $65.00 $267.00 | 257 | |
SP600125 is an inhibitor of c-Jun N-terminal kinase (JNK), which can regulate transcription factors and mRNA stability. By inhibiting JNK, SP600125 might disrupt pathways that are essential for the functional role of Imp3 in mRNA metabolism. | ||||||
PP242 | 1092351-67-1 | sc-301606A sc-301606 | 1 mg 5 mg | $56.00 $169.00 | 8 | |
PP242 is a selective mTOR kinase inhibitor, distinct from rapamycin. It inhibits both mTORC1 and mTORC2 complexes, which are central to regulating cell growth and protein synthesis. Inhibiting mTORC1/2 can thus impair the cellular processes where Imp3 functions. | ||||||
KU 0063794 | 938440-64-3 | sc-361219 | 10 mg | $209.00 | ||
Ku-0063794 is a potent and selective mTOR inhibitor that works on both mTORC1 and mTORC2. By inhibiting these complexes, it can disrupt the signaling required for the role of Imp3 in mRNA translation and ribosome biogenesis. | ||||||
AZD8055 | 1009298-09-2 | sc-364424 sc-364424A | 10 mg 50 mg | $160.00 $345.00 | 12 | |
AZD8055 is a potent ATP-competitive inhibitor of mTOR kinase in both mTORC1 and mTORC2. It can block the activation of downstream proteins that are involved in the translational machinery and could therefore inhibit the functional role of Imp3. | ||||||