ILT-3 Activators
ILT-3 Activators are a diverse array of chemical compounds that indirectly promote the functional activity of ILT-3 through distinct cellular signaling pathways. Forskolin and Sildenafil, by increasing intracellular cAMP levels, indirectly augment the functional activity of ILT-3 by activating PKA, which is known to phosphorylate proteins that could be involved in the modulation of ILT-3's role in the immune response. Similarly, Rolipram sustains this cAMP elevation by inhibiting its breakdown, which may result in prolonged PKA activation and enhancement of ILT-3 function. Curcumin, by inhibiting NF-κB, potentially reduces negative regulation of ILT-3, thus supporting its role in immune tolerance. Epigallocatechin gallate and Quercetin are kinase modulators that can influence ILT-3 activity by modifying intracellular signaling cascades that ILT-3 is implicated in. Resveratrol indirectly promotes ILT-3 function through the activation of SIRT1, which can lead to the deacetylation of transcription factors associated with ILT-3 expression.
Furthermore, Caffeine's inhibition of phosphodiesterases elevates cAMP levels, contributing to the enhancement of ILT-3 signaling through increased PKA activity. Retinoic acid, by altering dendritic cell maturation, provides a cellular context that can indirectly bolster ILT-3 signaling pathways. Piperine's inhibition of metabolic enzymes may lead to sustained signaling molecule levels, thereby potentially enhancing ILT-3's role in immune cell communication. Aspirin's anti-inflammatory action through COX enzyme inhibition could favor ILT-3.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin increases intracellular cAMP levels, which can enhance ILT-3 activity by promoting cAMP-dependent protein kinase A (PKA) signaling pathways that are known to phosphorylate proteins involved in ILT-3-mediated immune response modulation. | ||||||
Rolipram | 61413-54-5 | sc-3563 sc-3563A | 5 mg 50 mg | $77.00 $216.00 | 18 | |
Rolipram, a selective phosphodiesterase-4 inhibitor, prevents cAMP breakdown, thereby sustaining PKA activation and potentially enhancing ILT-3 signaling involved in immune tolerance. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Curcumin has been shown to inhibit NF-κB, a transcription factor that negatively regulates ILT-3 expression. By inhibiting NF-κB, curcumin may enhance ILT-3 activity by reducing its downregulation. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
This catechin inhibits the activity of certain kinases that negatively regulate ILT-3, thereby enhancing ILT-3's functional role in immune cell signaling. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Resveratrol activates SIRT1, which might lead to deacetylation of transcription factors that enhance the expression and function of ILT-3 in immune regulation. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $110.00 $250.00 $936.00 $50.00 | 33 | |
Quercetin is known to modulate kinase activity; by modulating these kinases, it may enhance ILT-3 activity through downstream signaling pathways that ILT-3 is involved in. | ||||||
Caffeine | 58-08-2 | sc-202514 sc-202514A sc-202514B sc-202514C sc-202514D | 50 g 100 g 250 g 1 kg 5 kg | $33.00 $67.00 $97.00 $192.00 $775.00 | 13 | |
Caffeine inhibits phosphodiesterases, leading to increased cAMP levels that can potentiate PKA activity and thereby enhance ILT-3 signaling. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
Retinoic acid modulates dendritic cell maturation and can indirectly enhance ILT-3 signaling by affecting the cellular context in which ILT-3 operates. | ||||||
Piperine | 94-62-2 | sc-205809 sc-205809A | 5 g 25 g | $37.00 $146.00 | 3 | |
Piperine inhibits enzymes that could degrade signaling molecules, thereby sustaining signaling cascades that enhance ILT-3 activity in immune cell communication. | ||||||
Aspirin | 50-78-2 | sc-202471 sc-202471A | 5 g 50 g | $20.00 $42.00 | 4 | |
Aspirin irreversibly inhibits COX enzymes, which could shift the balance of eicosanoids and potentially enhance the immune modulatory functions of ILT-3. | ||||||