IL-3R Inhibitors
IL-3R inhibitors are a class of chemical compounds that specifically target and inhibit the interleukin-3 receptor (IL-3R), a receptor complex primarily found on the surface of various hematopoietic cells, including stem cells, progenitor cells, and certain immune cells such as basophils and eosinophils. The IL-3 receptor is composed of an alpha subunit (IL-3Rα) responsible for binding the cytokine interleukin-3 (IL-3), and a beta subunit that is shared with other cytokine receptors like the GM-CSF receptor. IL-3 plays a critical role in the regulation of blood cell production and immune cell proliferation, differentiation, and survival. IL-3R inhibitors function by blocking the interaction between IL-3 and its receptor, preventing the activation of downstream signaling pathways that are essential for cell growth and survival.
The use of IL-3R inhibitors in research provides important insights into the biological functions of IL-3 and its receptor, particularly in the context of hematopoiesis and immune system regulation. By inhibiting IL-3R, researchers can examine how the disruption of this signaling pathway affects the behavior of hematopoietic cells, such as their ability to proliferate and differentiate into various cell types, including granulocytes and macrophages. Additionally, IL-3R inhibitors enable the study of how IL-3 signaling interacts with other cytokine pathways, offering a better understanding of the complex networks that regulate immune cell function and the development of blood cells. These inhibitors also help to clarify the role of IL-3 in orchestrating the immune response, particularly in inflammation and the mobilization of immune cells during stress or infection. Through these studies, IL-3R inhibitors serve as a valuable tool for investigating the molecular mechanisms underlying cytokine receptor signaling and its influence on hematopoietic and immune processes.
SEE ALSO...
Items 1 to 10 of 12 total
Display:
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Pimozide | 2062-78-4 | sc-203662 | 100 mg | $102.00 | 3 | |
Pimozide could downregulate IL-3R expression by antagonizing central dopamine receptors, which may have a downstream effect on the transcriptional activity of genes involved in cytokine receptor expression, including IL3RA. | ||||||
Stat3 inhibitor V, stattic | 19983-44-9 | sc-202818 sc-202818A sc-202818B sc-202818C sc-202818D sc-202818E sc-202818F | 25 mg 100 mg 250 mg 500 mg 1 g 2.5 g 5 g | $127.00 $192.00 $269.00 $502.00 $717.00 $1380.00 $2050.00 | 114 | |
Stattic may specifically inhibit the transcription factor STAT3, which is necessary for initiating IL-3R alpha chain gene expression, thereby reducing levels of IL-3R on the cell surface. | ||||||
Fludarabine | 21679-14-1 | sc-204755 sc-204755A | 5 mg 25 mg | $57.00 $200.00 | 15 | |
Fludarabine, as a nucleoside analog, could decrease IL-3R expression by disrupting the synthesis of RNA and DNA, impairing the transcription machinery required for the production of the IL3RA gene transcripts. | ||||||
Stat3 Inhibitor III, WP1066 | 857064-38-1 | sc-203282 | 10 mg | $132.00 | 72 | |
WP1066 might inhibit JAK2/STAT3 signaling, a pathway that promotes the expression of IL-3R alpha chain, and thus could lead to a decrease in IL-3R surface expression levels. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
PD 98059 is a selective inhibitor of MEK1/2, which are kinases in the ERK pathway; inhibition could lead to a reduction in IL-3R expression by preventing activation of transcription processes that upregulate IL3RA. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY 294002 could inhibit IL-3R expression by obstructing the PI3K/AKT signaling pathway, which is responsible for the transcription and translation processes that include the synthesis of IL-3R. | ||||||
Tyrphostin B42 | 133550-30-8 | sc-3556 | 5 mg | $26.00 | 4 | |
Tyrphostin B42 is known to inhibit JAK2 kinase activity, which is essential for IL-3R expression; hence, its presence could result in the decreased presence of IL-3R on cells due to the suppression of IL3RA gene transcription. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
SP600125 might decrease IL-3R expression by inhibiting the activity of JNK, which in turn could reduce the transcriptional activity of genes involved in the expression of IL-3R alpha chain. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $63.00 $241.00 | 136 | |
U0126 may directly inhibit MEK1/2, leading to a reduction in ERK pathway signaling and subsequent downregulation of IL-3R expression due to diminished transcriptional activation of the IL3RA gene. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
SB 203580 can potentially reduce IL-3R expression by inhibiting p38 MAPK, which is a kinase responsible for signaling pathways that control the production of IL-3R via gene transcription. | ||||||