Il-28a Inhibitors
Il-28a inhibitors represent a class of chemical compounds designed to target and interfere with the activity of Interleukin-28a (IL-28a). IL-28a is a cytokine, a type of small signaling protein, that plays a significant role in the immune system's response to infections, particularly viral infections. These inhibitors are developed to modulate the function of IL-28a, which is involved in various immune-related processes such as antiviral defense, immune cell activation, and the regulation of inflammation.
The primary mechanism of action for IL-28a inhibitors typically involves their interaction with the IL-28a protein or its associated molecules, leading to the disruption of its normal signaling functions. By inhibiting IL-28a, these compounds have the potential to influence immune responses, including the antiviral defense mechanisms mediated by IL-28a. Researchers studying IL-28a inhibitors aim to uncover the specific roles of IL-28a in the immune system, contributing to our understanding of its functions in the context of viral infections and immune responses. These inhibitors serve as valuable tools for advancing our knowledge of the complex interplay between cytokines like IL-28a and the immune system's defense mechanisms. In this context, they play a significant role in furthering our understanding of immunology and host defense mechanisms against viral pathogens.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Aminophylline | 317-34-0 | sc-252368 | 25 g | $36.00 | ||
Aminophylline, a phosphodiesterase inhibitor, may reduce IL-28A expression by increasing intracellular cAMP levels, affecting cytokine regulation. | ||||||
Budesonide | 51333-22-3 | sc-202980 sc-202980A sc-202980B sc-202980C | 50 mg 100 mg 200 mg 500 mg | $77.00 $88.00 $151.00 $343.00 | 3 | |
Budesonide, a glucocorticoid, can suppress cytokine production by transrepression of transcription factors like NF-κB. | ||||||
Zileuton | 111406-87-2 | sc-204417 sc-204417A sc-204417B sc-204417C | 10 mg 50 mg 1 g 75 g | $82.00 $301.00 $362.00 $1229.00 | 8 | |
Zileuton, a 5-lipoxygenase inhibitor, might inhibit IL-28A expression by blocking leukotriene synthesis, which is involved in inflammation. | ||||||
12β-Hydroxydigitoxin | 20830-75-5 | sc-213604 sc-213604A | 1 g 5 g | $140.00 $680.00 | ||
12β-Hydroxydigitoxin has been suggested to interfere with cellular signaling, potentially leading to the suppression of some cytokines, including IL-28A. | ||||||
Flavopiridol | 146426-40-6 | sc-202157 sc-202157A | 5 mg 25 mg | $78.00 $254.00 | 41 | |
Flavopiridol inhibits cyclin-dependent kinases and could reduce IL-28A expression by altering cell cycle-dependent signaling. | ||||||
NFκB Activation Inhibitor II, JSH-23 | 749886-87-1 | sc-222061 sc-222061C sc-222061A sc-222061B | 5 mg 10 mg 50 mg 100 mg | $210.00 $252.00 $1740.00 $1964.00 | 34 | |
JSH-23 is an inhibitor of NF-κB translocation and may decrease IL-28A expression by blocking this transcription factor's activity. | ||||||
Caffeic Acid | 331-39-5 | sc-200499 sc-200499A | 1 g 5 g | $31.00 $61.00 | 1 | |
Caffeic acid phenethyl ester can modulate NF-κB signaling, potentially reducing the expression of cytokines such as IL-28A. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
PD98059 is a MEK inhibitor that might suppress IL-28A expression by inhibiting the MAPK/ERK pathway, which is involved in cytokine gene regulation. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $88.00 $342.00 | 284 | |
SB203580, a p38 MAP kinase inhibitor, could downregulate the expression of IL-28A by affecting the p38 MAPK signaling pathway. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $66.00 $219.00 $417.00 | 97 | |
Wortmannin is a PI3K inhibitor that may lead to decreased IL-28A expression by disrupting the PI3K/Akt signaling pathway. | ||||||