IL-27 Activators
Interleukin-27 (IL-27) is a cytokine belonging to the IL-12 family, which plays a critical role in the regulation of immune system responses. This protein is primarily produced by antigen-presenting cells, including macrophages and dendritic cells. IL-27 is composed of two subunits, EBI3 (Epstein-Barr virus-induced gene 3) and p28, which together form a biologically active heterodimer. As a multifaceted cytokine, IL-27 exerts both pro-inflammatory and anti-inflammatory effects, making it a unique modulator of immune responses. Its ability to enhance Th1 cell differentiation, which is crucial for combating intracellular pathogens, underscores its pro-inflammatory role. Conversely, IL-27 contributes to the suppression of Th17 responses and the promotion of regulatory T cell development, highlighting its anti-inflammatory and immunosuppressive capabilities. This dual functionality allows IL-27 to maintain a delicate balance within the immune system, preventing overactivation that could lead to autoimmune diseases while ensuring adequate response to infections and malignancies.
The mechanisms governing IL-27 activation and its subsequent effects on immune cells are intricate and highly regulated. Activation of IL-27 involves its interaction with a specific receptor complex composed of IL-27Rα (WSX-1) and gp130. Upon binding to its receptor, IL-27 triggers the JAK/STAT signaling pathway, particularly activating STAT1 and STAT3 transcription factors. These factors then translocate to the nucleus, where they influence the expression of genes involved in immune regulation, including those that promote the differentiation of naïve T cells into Th1 cells and regulatory T cells. This signaling cascade underscores the critical role of IL-27 in bridging innate and adaptive immunity, facilitating rapid and coordinated responses to pathogens. Additionally, IL-27 influences the production of cytokines and chemokines, further modulating the immune landscape.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
Resveratrol activates SIRT1, which is involved in anti-inflammatory pathways that can enhance the activity of IL-27, promoting its anti-inflammatory and immunoregulatory effects. This activation supports IL-27's role in modulating immune responses. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $36.00 $68.00 $107.00 $214.00 $234.00 $862.00 $1968.00 | 47 | |
Curcumin activates NF-κB signaling, indirectly enhancing IL-27 production and function. This activation aids in the modulation of immune responses, particularly in anti-inflammatory processes, by promoting IL-27's immunoregulatory activities. | ||||||
D,L-Sulforaphane | 4478-93-7 | sc-207495A sc-207495B sc-207495C sc-207495 sc-207495E sc-207495D | 5 mg 10 mg 25 mg 1 g 10 g 250 mg | $150.00 $286.00 $479.00 $1299.00 $8299.00 $915.00 | 22 | |
Sulforaphane activates the Nrf2 pathway, which is linked to anti-inflammatory actions and can enhance IL-27's role in immune regulation. This supports the protein's involvement in controlling inflammatory responses and its capacity to modulate immune system activities. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
EGCG, a potent antioxidant found in green tea, can activate pathways that bolster IL-27's regulatory functions on immune cells, thereby enhancing the protein's role in anti-inflammatory responses and immune system modulation. | ||||||
Piperine | 94-62-2 | sc-205809 sc-205809A | 5 g 25 g | $36.00 $143.00 | 3 | |
Piperine enhances the bioavailability of other activators and can indirectly support the pathways that activate IL-27, thus promoting its role in immune regulation and its anti-inflammatory effects. | ||||||
Capsaicin | 404-86-4 | sc-3577 sc-3577C sc-3577D sc-3577A | 50 mg 250 mg 500 mg 1 g | $94.00 $173.00 $255.00 $423.00 | 26 | |
Capsaicin activates TRPV1 channels, which can lead to the activation of pathways that support IL-27's functions in immune modulation and inflammation control, thereby enhancing the protein's regulatory effects. | ||||||
Indole-3-carbinol | 700-06-1 | sc-202662 sc-202662A sc-202662B sc-202662C sc-202662D | 1 g 5 g 100 g 250 g 1 kg | $38.00 $60.00 $143.00 $306.00 $1012.00 | 5 | |
Indole-3-carbinol modulates the AhR pathway, which is connected to immune response regulation. This modulation supports IL-27's functions in immune system regulation and its role in anti-inflammatory processes. | ||||||
Caffeic acid phenethyl ester | 104594-70-9 | sc-200800 sc-200800A sc-200800B | 20 mg 100 mg 1 g | $70.00 $290.00 $600.00 | 19 | |
CAPE inhibits NF-κB, indirectly supporting IL-27 activation by reducing pro-inflammatory signals, thus enhancing IL-27's anti-inflammatory and immune regulatory activities. | ||||||
Silymarin group, mixture of isomers | 65666-07-1 | sc-301806 | 50 g | $319.00 | ||
Silymarin, through its antioxidative properties, activates pathways that can support IL-27's role in immune system regulation and its anti-inflammatory actions, thus indirectly promoting IL-27's functional activation in immune responses. | ||||||
Ursolic Acid | 77-52-1 | sc-200383 sc-200383A | 50 mg 250 mg | $55.00 $176.00 | 8 | |
Ursolic acid, by modulating signaling pathways involved in inflammation, supports IL-27's activation and its role in immune regulation, thereby enhancing the protein's function in modulating immune responses and controlling inflammation. | ||||||