IL-13 Inhibitors
The chemical class termed IL-13 inhibitors comprises a distinctive group of compounds meticulously designed to modulate the biological activity of Interleukin-13 (IL-13), a cytokine central to various inflammatory and immune responses. These inhibitors are crafted with precision to interact with IL-13, influencing its signaling pathways and downstream effects. IL-13 is intricately involved in processes ranging from allergic reactions to immune-related disorders, making it a notable target of interest.
The core mechanism underlying IL-13 inhibitors involves their specific interaction with IL-13. This interaction effectively disrupts IL-13's engagement with cellular receptors and other key molecules that orchestrate its signaling cascade. By interrupting IL-13's functional engagement, these inhibitors have the potential to exert a significant influence on immune responses and inflammation driven by IL-13 signaling. Structurally, members of this chemical class often share distinct features that facilitate their interaction with IL-13. This allows them to modulate the functional outcomes of IL-13 activity. The exploration of IL-13 inhibitors delves into the intricate processes of cytokine signaling, offering potential insights into the mechanisms that govern immune responses and inflammation. Through dedicated research and rigorous experimentation, scientists endeavor to unravel the nuances of IL-13 inhibition and its broader implications for immune regulation and associated processes.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Zileuton | 111406-87-2 | sc-204417 sc-204417A sc-204417B sc-204417C | 10 mg 50 mg 1 g 75 g | $82.00 $301.00 $362.00 $1229.00 | 8 | |
Zileuton, a 5-lipoxygenase inhibitor, decreases leukotriene production, a critical component in the inflammatory response. By reducing leukotriene levels, zileuton indirectly affects pathways that lead to the reduction of IL-13 secretion in allergic inflammation. | ||||||
Methotrexate | 59-05-2 | sc-3507 sc-3507A | 100 mg 500 mg | $92.00 $209.00 | 33 | |
Methotrexate, a dihydrofolate reductase inhibitor, is known to exert immunosuppressive effects. By modulating the immune response, methotrexate can indirectly lead to a decrease in IL-13 production as part of its anti-inflammatory effects. | ||||||
hydroxychloroquine | 118-42-3 | sc-507426 | 5 g | $56.00 | 1 | |
Hydroxychloroquine, an antimalarial drug with anti-inflammatory properties, can indirectly inhibit IL-13 production by modulating immune activity. Its precise mechanism suggests an interference with lysosomal activity and suppression of immune activation. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $36.00 $68.00 $107.00 $214.00 $234.00 $862.00 $1968.00 | 47 | |
Curcumin, a bioactive compound from turmeric, has been shown to modulate multiple signaling pathways, including NF-κB, which is involved in inflammatory response regulation. This modulation can lead to an indirect reduction in IL-13 levels. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $108.00 $245.00 $918.00 $49.00 | 33 | |
Quercetin, a flavonoid with antioxidant properties, indirectly inhibits IL-13 by modulating the signaling pathways involved in inflammation and immune response, thereby potentially reducing the production and activity of IL-13 in allergic and inflammatory processes. | ||||||
Apigenin | 520-36-5 | sc-3529 sc-3529A sc-3529B sc-3529C sc-3529D sc-3529E sc-3529F | 5 mg 100 mg 1 g 5 g 25 g 100 g 1 kg | $32.00 $210.00 $720.00 $1128.00 $2302.00 $3066.00 $5106.00 | 22 | |
Apigenin, a flavone found in many plants, has been reported to influence various signaling pathways, including those involved in inflammation. By modulating these pathways, apigenin can indirectly reduce IL-13 levels through anti-inflammatory effects. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
Resveratrol, a polyphenolic compound, exerts anti-inflammatory effects by modulating signaling pathways such as SIRT1 and NF-κB. Through these actions, resveratrol can indirectly contribute to the reduction of IL-13 production in inflammatory conditions. | ||||||
N-Acetyl-L-cysteine | 616-91-1 | sc-202232 sc-202232A sc-202232C sc-202232B | 5 g 25 g 1 kg 100 g | $33.00 $73.00 $265.00 $112.00 | 34 | |
N-Acetyl-L-cysteine, an antioxidant and precursor to glutathione, modulates oxidative stress and inflammation. By affecting the redox state of cells, it can indirectly lead to a decrease in IL-13 production as part of its broader anti-inflammatory effects. | ||||||
Sulfasalazine | 599-79-1 | sc-204312 sc-204312A sc-204312B sc-204312C | 1 g 2.5 g 5 g 10 g | $60.00 $75.00 $125.00 $205.00 | 8 | |
Sulfasalazine indirectly reduces IL-13 levels by inhibiting NF-κB, a key transcription factor in the inflammatory response, thereby modulating the immune response and reducing IL-13 production. | ||||||
Budesonide | 51333-22-3 | sc-202980 sc-202980A sc-202980B sc-202980C | 50 mg 100 mg 200 mg 500 mg | $77.00 $88.00 $151.00 $343.00 | 3 | |
Budesonide, a glucocorticoid steroid, reduces inflammation by modulating the expression of genes involved in the inflammatory response. This modulation can lead to an indirect reduction in IL-13 production, due to its potent anti-inflammatory properties. | ||||||