IL-10Rα Inhibitors
Interleukin-10 Receptor Alpha Inhibitors, often abbreviated as IL-10Rα inhibitors, represent a class of small molecules or biologics designed to modulate the immune system's response by targeting the interleukin-10 receptor alpha (IL-10Rα). IL-10Rα is a transmembrane protein that plays a pivotal role in regulating the immune system's inflammatory response. It is primarily expressed on the surface of various immune cells, including monocytes, macrophages, and T cells. IL-10Rα is a critical component of the IL-10 signaling pathway, which is responsible for dampening down excessive immune responses and maintaining immune homeostasis.
IL-10Rα inhibitors work by interfering with the binding of interleukin-10 (IL-10) to its receptor, IL-10Rα. When IL-10 binds to IL-10Rα, it activates downstream signaling pathways that promote an anti-inflammatory response, inhibiting the production of pro-inflammatory cytokines and reducing immune cell activation. By inhibiting this interaction, IL-10Rα inhibitors can modulate the immune response, shifting it towards a more pro-inflammatory state. This modulation has applications in various medical conditions where immune dysregulation is a key factor, such as autoimmune diseases, inflammatory disorders, and certain types of cancer. Researchers continue to explore the mechanisms of action of IL-10Rα inhibitors, aiming to develop innovative approaches to managing immune-related conditions through the precise control of immune responses.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Curcumin may downregulate IL-10Rα expression by modulating transcription factors and inhibiting signaling pathways associated with inflammation. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Resveratrol might suppress IL-10Rα expression through its antioxidant activity, which can affect cytokine signaling pathways. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $110.00 $250.00 $936.00 $50.00 | 33 | |
Quercetin is known to modulate various signaling pathways, potentially leading to decreased expression of IL-10Rα by influencing transcriptional activity. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
EGCG, the major catechin in green tea, can alter inflammatory pathways and possibly reduce IL-10Rα expression through epigenetic modifications. | ||||||
D,L-Sulforaphane | 4478-93-7 | sc-207495A sc-207495B sc-207495C sc-207495 sc-207495E sc-207495D | 5 mg 10 mg 25 mg 1 g 10 g 250 mg | $153.00 $292.00 $489.00 $1325.00 $8465.00 $933.00 | 22 | |
Sulforaphane may inhibit IL-10Rα expression by modulating NF-κB activity, which is a key regulator of inflammatory cytokine signaling. | ||||||
Indole-3-carbinol | 700-06-1 | sc-202662 sc-202662A sc-202662B sc-202662C sc-202662D | 1 g 5 g 100 g 250 g 1 kg | $39.00 $61.00 $146.00 $312.00 $1032.00 | 5 | |
Indole-3-carbinol might alter hormone metabolism and modulate immune response, potentially reducing IL-10Rα expression. | ||||||
Andrographolide | 5508-58-7 | sc-205594 sc-205594A | 50 mg 100 mg | $15.00 $40.00 | 7 | |
Andrographolide may influence immune cell signaling, which could lead to decreased expression of IL-10Rα through interference with transcription factors. | ||||||
Apigenin | 520-36-5 | sc-3529 sc-3529A sc-3529B sc-3529C sc-3529D sc-3529E sc-3529F | 5 mg 100 mg 1 g 5 g 25 g 100 g 1 kg | $33.00 $214.00 $734.00 $1151.00 $2348.00 $3127.00 $5208.00 | 22 | |
Apigenin is believed to have anti-inflammatory properties that could result in the downregulation of IL-10Rα by affecting related signaling pathways. | ||||||
Wogonin, S. baicalensis | 632-85-9 | sc-203313 | 10 mg | $200.00 | 8 | |
Wogonin can affect various molecular targets involved in inflammation, possibly decreasing IL-10Rα expression by altering cytokine profiles. | ||||||
Kaempferol | 520-18-3 | sc-202679 sc-202679A sc-202679B | 25 mg 100 mg 1 g | $99.00 $216.00 $510.00 | 11 | |
Kaempferol may downregulate the expression of IL-10Rα through the modulation of signaling pathways and transcription factors involved in inflammation. | ||||||