IGFL3 Activators
IGFL3 can engage diverse cellular signaling pathways to modulate the activity of this protein. Forskolin is a compound that directly stimulates adenylyl cyclase, which increases the levels of cAMP within the cell, leading to the activation of protein kinase A (PKA). PKA, in turn, can phosphorylate various proteins, potentially including IGFL3 if it falls under PKA's substrate profile. Similarly, Dibutyryl-cAMP (db-cAMP), a cell-permeable analog of cAMP, can also activate PKA, which could result in the phosphorylation and consequent activation of IGFL3. (-)-Isoproterenol hydrochloride functions as a beta-adrenergic receptor agonist and raises cAMP levels, similarly leading to PKA activation and possibly impacting IGFL3 activity.
PDBu (Phorbol 12,13-dibutyrate) activates protein kinase C (PKC), which phosphorylates a wide array of proteins and could include IGFL3 if it is a substrate for PKC. Ionomycin, by raising intracellular calcium levels, could initiate calcium-dependent kinase pathways such as calmodulin-dependent kinase (CaMK), which may phosphorylate IGFL3. Insulin, through its receptor, triggers a cascade involving phosphoinositide 3-kinase (PI3K) and AKT, which could lead to the activation of IGFL3 if it is a downstream effector. Epidermal Growth Factor (EGF) stimulates its receptor to activate both MAPK and PI3K-AKT pathways, which may impinge upon IGFL3. Anisomycin, known as a protein synthesis inhibitor, also activates stress-activated protein kinases such as JNK, which might target IGFL3 in stress response signaling. Calyculin A and Okadaic Acid, both inhibitors of protein phosphatases PP1 and PP2A, could maintain IGFL3 in a phosphorylated, and thus active, state by preventing dephosphorylation. Lastly, Lithium chloride inhibits glycogen synthase kinase 3 (GSK-3), potentially leading to the activation of Wnt signaling pathway, which might involve IGFL3 activation if it is associated with this pathway or with proteins regulated by GSK-3.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Phorbol-12,13-dibutyrate | 37558-16-0 | sc-202285 | 1 mg | $124.00 | 3 | |
PDBu is a phorbol ester that activates protein kinase C (PKC). Activated PKC can phosphorylate a variety of protein targets potentially including IGFL3 if it is within the range of PKC substrates, leading to its functional activation. | ||||||
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $78.00 $270.00 | 80 | |
Ionomycin is a calcium ionophore that increases intracellular calcium concentrations. Elevated calcium can activate calcium-dependent signaling pathways such as calmodulin-dependent kinase (CaMK) which could phosphorylate and activate IGFL3 if it is sensitive to calcium-dependent signaling. | ||||||
Insulin | 11061-68-0 | sc-29062 sc-29062A sc-29062B | 100 mg 1 g 10 g | $156.00 $1248.00 $12508.00 | 82 | |
Insulin activates the insulin receptor which initiates a signaling cascade involving PI3K and AKT. If IGFL3 is downstream of AKT, then insulin could lead to the phosphorylation and activation of IGFL3 through AKT-mediated signaling pathways. | ||||||
Anisomycin | 22862-76-6 | sc-3524 sc-3524A | 5 mg 50 mg | $99.00 $259.00 | 36 | |
Anisomycin is a protein synthesis inhibitor that also activates stress-activated protein kinases like JNK. Assuming IGFL3 is a target of JNK or is involved in stress response pathways, anisomycin could activate IGFL3 through JNK-mediated phosphorylation. | ||||||
Penicillamine | 52-67-5 | sc-205795 sc-205795A | 1 g 5 g | $46.00 $96.00 | ||
This compound releases nitric oxide which can activate soluble guanylyl cyclase, leading to increased levels of cGMP. If IGFL3 functions are regulated by cGMP-dependent protein kinases such as PKG, this compound could activate IGFL3 through phosphorylation via PKG. | ||||||
Calyculin A | 101932-71-2 | sc-24000 sc-24000A | 10 µg 100 µg | $163.00 $800.00 | 59 | |
Calyculin A is an inhibitor of protein phosphatases 1 (PP1) and 2A (PP2A). By inhibiting dephosphorylation, it can indirectly lead to the increased phosphorylation state of proteins. If IGFL3 is normally regulated through phosphorylation, calyculin A could maintain IGFL3 in an activated state by preventing its dephosphorylation. | ||||||
Dibutyryl-cAMP | 16980-89-5 | sc-201567 sc-201567A sc-201567B sc-201567C | 20 mg 100 mg 500 mg 10 g | $47.00 $136.00 $492.00 $4552.00 | 74 | |
db-cAMP is a cell-permeable cAMP analog that activates PKA. Activated PKA could phosphorylate and activate IGFL3 if it is a PKA substrate or is involved in PKA-regulated signaling pathways. | ||||||
Isoproterenol Hydrochloride | 51-30-9 | sc-202188 sc-202188A | 100 mg 500 mg | $28.00 $38.00 | 5 | |
(-)-Isoproterenol is a non-selective beta-adrenergic receptor agonist that can increase intracellular levels of cAMP, subsequently activating PKA. If IGFL3 is a part of the PKA signaling pathway, then this compound could result in the activation of IGFL3. | ||||||
Okadaic Acid | 78111-17-8 | sc-3513 sc-3513A sc-3513B | 25 µg 100 µg 1 mg | $291.00 $530.00 $1800.00 | 78 | |
Okadaic acid is a potent inhibitor of PP1 and PP2A, similar to calyculin A. By inhibiting these phosphatases, it could increase the phosphorylation and activation of IGFL3 assuming that its activation state is regulated by phosphorylation. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Lithium chloride inhibits glycogen synthase kinase 3 (GSK-3). Inhibition of GSK-3 can lead to the activation of the Wnt signaling pathway, which involves protein phosphorylation. If IGFL3 activation is linked to the Wnt pathway or proteins regulated by GSK-3, lithium chloride could result in the functional activation of IGFL3 through this mechanism. | ||||||