IFN-γRα Inhibitors
The chemical class known as IFN-γRα inhibitors encompasses a group of compounds designed to target the interferon-gamma receptor alpha (IFN-γRα). This transmembrane protein is notably expressed on immune cells and pivotal in mediating cellular responses to interferon-gamma (IFN-γ), a cytokine recognized for its role in inflammation and immune defense. IFN-γRα inhibitors, constituting diverse small molecules and biologics, operate by disrupting the interaction between IFN-γ and its receptor.
The structural diversity of IFN-γRα inhibitors is striking, with various architectures tailored to interact with specific sites on either the IFN-γRα receptor or the cytokine itself. This interaction disruption impedes downstream signaling initiated by IFN-γ binding, effectively regulating immune responses. Researchers have delved into the intricate design and synthesis of these inhibitors, optimizing their affinity, selectivity, and pharmacokinetic profiles. Insights garnered from structural adjustments and activity relationship studies shed light on the intricate molecular interactions essential for inhibiting IFN-γ binding. By refining the chemical structure of these inhibitors, researchers strive to enhance specificity and potency in altering IFN-γ signaling. In summation, IFN-γRα inhibitors stand as promising tools for unraveling immune response intricacies and opening avenues for future immunological breakthroughs.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Ruxolitinib | 941678-49-5 | sc-364729 sc-364729A sc-364729A-CW | 5 mg 25 mg 25 mg | $251.00 $500.00 $547.00 | 16 | |
Ruxolitinib is another JAK inhibitor that primarily targets JAK1 and JAK2. Its action on JAKs disrupts the IFN-γ signaling pathway by hindering STAT activation and subsequent gene expression related to inflammation and immune responses. | ||||||
Baricitinib | 1187594-09-7 | sc-364730 sc-364730A | 5 mg 25 mg | $200.00 $664.00 | ||
Baricitinib is a JAK1 and JAK2 inhibitor that modulates the IFN-γ signaling pathway by preventing JAK-mediated phosphorylation of STAT proteins, thus mitigating the downstream effects of IFN-γ receptor activation. | ||||||
Tryptanthrin | 13220-57-0 | sc-202844 sc-202844A | 1 mg 5 mg | $50.00 $213.00 | ||
Tryptanthrin is an alkaloid that suppresses IFN-γ signaling by inhibiting the JAK-STAT pathway, particularly by blocking STAT1 activation. This leads to reduced transcription of IFN-γ-responsive genes involved in inflammation and immunity. | ||||||
Tyrphostin B42 | 133550-30-8 | sc-3556 | 5 mg | $26.00 | 4 | |
AG 490 is a tyrosine kinase inhibitor that targets JAK2 and epidermal growth factor receptor (EGFR). It attenuates IFN-γ signaling by inhibiting JAK2-mediated phosphorylation of STAT1 and other downstream events. | ||||||
AZD1480 | 935666-88-9 | sc-364735 sc-364735A | 5 mg 50 mg | $124.00 $1072.00 | 11 | |
AZD1480 is a JAK2 inhibitor that impedes IFN-γ signaling by preventing JAK2-mediated phosphorylation of STAT1, thereby reducing the expression of genes involved in immune responses and inflammation. | ||||||
Cepharanthine | 481-49-2 | sc-391213 sc-391213A | 100 mg 500 mg | $45.00 $150.00 | 2 | |
Cepharanthine inhibits JAK2 and JAK3, impeding the IFN-γ signaling pathway. By doing so, it hampers the activation of STAT proteins and the subsequent transcription of genes that contribute to inflammation and immune responses. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Curcumin modulates IFN-γ signaling by inhibiting JAK2 and JAK3 activities. Its interference with JAK-mediated STAT phosphorylation leads to reduced gene expression of pro-inflammatory cytokines and immune-related molecules. | ||||||
Cryptotanshinone | 35825-57-1 | sc-280649 | 10 mg | $119.00 | 1 | |
Cryptotanshinone is a natural compound that inhibits JAK2 and JAK3, affecting the IFN-γ signaling pathway. Through this inhibition, it downregulates the activation of STAT proteins and the subsequent transcription of immune and inflammatory genes. | ||||||
Daphnetin | 486-35-1 | sc-203022 | 10 mg | $84.00 | ||
Daphnetin interferes with IFN-γ signaling by inhibiting JAK2 and JAK3. This inhibition results in the suppression of downstream phosphorylation events, including STAT activation, leading to reduced immune and inflammatory responses. | ||||||
SB 202190 | 152121-30-7 | sc-202334 sc-202334A sc-202334B | 1 mg 5 mg 25 mg | $31.00 $128.00 $454.00 | 45 | |
Pyridone 6 is a JAK inhibitor that targets JAK1 and JAK2. Its mechanism involves blocking the phosphorylation of STAT1 and other downstream events in the IFN-γ signaling pathway, thus mitigating immune and inflammatory responses elicited by IFN-γ. | ||||||