Molecular structure of Tryptanthrin, CAS Number: 13220-57-0
Tryptanthrin (CAS 13220-57-0)
Application:
Tryptanthrin is a potent inhibitor of Cox-2 and NOS II
CAS Number:
13220-57-0
Purity:
≥98%
Molecular Weight:
248.24
Molecular Formula:
C15H8N2O2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Tryptanthrin is a potent inhibitor of prostaglandin and leukotriene synthesis in various cell lines. Tryptanthrin is a selective inhibitor of cyclooxygenase-2 (Cox-2). Tryptanthrin is an inhibitor of inducible nitric oxide synsthase (iNOS; NOS II) expression. Tryptanthrin inhibits the production of IFN-γ and IL-2 after stimulation of Peyer′s patch lymphocytes with staphylococcal enterotoxin B (SEB). Tryptanthrin inhibits P-glycoprotein (Pgp) (expressed by the MDR1 gene) and reverses doxorubicin resistance on breast cancer cells.
Tryptanthrin (CAS 13220-57-0) References
1. H. Danz, et al.; Arch. Pharm. Suppl. I 333, 11 (2000). 2. Identification and isolation of the cyclooxygenase-2 inhibitory principle in Isatis tinctoria: H. Danz, et al.; Planta Med. 67, 411 (2001). 3. Inhibitory activity of tryptanthrin on prostaglandiInhibitor of:
Cox-2, HSPA4L, and IFN-γRα.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Tryptanthrin, 1 mg | sc-202844 | 1 mg | $50.00 | |||
Tryptanthrin, 5 mg | sc-202844A | 5 mg | $213.00 |