IFN-α8 Inhibitors
Inhibitors of IFN-α8 function by disrupting specific signaling pathways that are crucial for the protein's activity. These inhibitors target key enzymes and kinases that are directly or indirectly involved in the signaling cascades initiated by IFN-α8. For instance, the inhibition of JAK kinase results in the blockade of the JAK-STAT pathway, which is essential for the transcriptional activity induced by IFN-α8. Similarly, the suppression of IKK leads to reduced activation of the NF-κB pathway, a vital route for the expression and function of IFN-α8 in immune responses. These inhibitors function by preventing the phosphorylation, dimerization, and nuclear translocation of various transcription factors that are otherwise activated by IFN-α8, thus diminishing the protein's ability to modulate gene expression related to antiviral and immunomodulatory processes.
Moreover, some inhibitors act by impeding other critical signaling molecules such as PI3K, AKT, MEK, ERK, mTOR, and JNK. These molecules participate in complex signaling networks that contribute to the cellular effects of IFN-α8, including its antiviral defenses and modulation of immune cell function. By inhibiting these key signaling nodes, the inhibitors effectively reduce the functional activity of IFN-α8. The targeted nature of these inhibitors ensures that the disruption is specific to the pathways that IFN-α8 utilizes, rather than a broad inhibition of cellular signaling processes. This specificity is crucial for achieving a decrease in IFN-α8 activity without affecting unrelated cellular functions, providing a focused approach to diminishing the protein's influence on the immune system.
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Items 1 to 10 of 11 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
JAK Inhibitor I | 457081-03-7 | sc-204021 sc-204021A | 500 µg 1 mg | $156.00 $339.00 | 59 | |
Selectively targets Janus kinase (JAK) involved in the JAK-STAT signaling pathway. IFN-α8 signals through this pathway, and inhibition of JAK prevents the phosphorylation and subsequent dimerization of STAT proteins, leading to reduced IFN-α8 signaling. | ||||||
BMS-345541 | 445430-58-0 | sc-221741 | 1 mg | $312.00 | 1 | |
Selective inhibitor of the IκB kinase (IKK), which is crucial for NF-κB activation. NF-κB is involved in the expression of IFN-α8 and its inhibition compromises IFN-α8-mediated immune responses. | ||||||
Tyrphostin B42 | 133550-30-8 | sc-3556 | 5 mg | $26.00 | 4 | |
Tyrosine kinase inhibitor that impedes JAK2 activity, one of the kinases activated by IFN-α8 binding. This prevents subsequent activation of STATs, leading to decreased IFN-α8 signal transduction. | ||||||
Ruxolitinib | 941678-49-5 | sc-364729 sc-364729A sc-364729A-CW | 5 mg 25 mg 25 mg | $251.00 $500.00 $547.00 | 16 | |
A potent JAK1 and JAK2 inhibitor that blocks IFN-α8 signaling through the JAK-STAT pathway, diminishing the biological effects mediated by IFN-α8. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
A PI3K inhibitor that downregulates the PI3K-AKT pathway, indirectly affecting the stability and function of IFN-α8 by altering cellular survival and proliferation signals. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $90.00 $349.00 | 284 | |
This compound inhibits p38 MAP kinase, which is involved in the signaling pathway of IFN-α8, particularly in the production of inflammatory cytokines, thereby reducing IFN-α8's functional activity. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $67.00 $223.00 $425.00 | 97 | |
Inhibits phosphoinositide 3-kinases (PI3K), which are involved in IFN-α8-induced signaling pathways, particularly affecting the AKT signaling cascade downstream of IFN-α8. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $40.00 $92.00 | 212 | |
Selectively inhibits MEK, which is upstream of the ERK pathway. ERK pathway is implicated in the signaling of IFN-α8, and its inhibition leads to decreased activity of IFN-α8. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $63.00 $158.00 $326.00 | 233 | |
An mTOR inhibitor, which can indirectly affect IFN-α8 activity by modulating the cell's response to IFN-α8 through the mTOR signaling pathway. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $64.00 $246.00 | 136 | |
A MEK1/2 inhibitor that blocks the activation of the MAPK/ERK pathway, downstream of the IFN-α8 receptor signaling, thus reducing the efficacy of IFN-α8 signaling. | ||||||