IFN-α8 Activators
IFN-α8 activators are chemical compounds that enhance the activity of this interferon through various biochemical mechanisms. By directly stimulating adenylate cyclase, certain activators cause an elevation in cyclic AMP levels, which is instrumental in fortifying the signal transduction pathways associated with IFN-α8, thereby amplifying its functional activity. Other activators function as agonists at specific Toll-like receptors (TLRs), such as TLR7 and TLR8, which initiate a signaling cascade that activates key transcription factors like NF-κB and IRF7. These transcription factors are crucial in upregulating the expression of IFN-α8. Synthetic analogs of viral components, such as double-stranded RNA, engage with TLR3 or mimic viral RNA to activate RIG-I like receptors, which signal through intermediaries to induce the production of IFN-α8.
Some IFN-α8 activators work by inducing cellular stress responses, such as the unfolded protein response, which can result in the activation of this interferon. For example, certain nucleotide analogs can activate endogenous RNA sensors as part of the antiviral response, leading to an increase in IFN-α8 expression and activity. Inhibitors of protein synthesis can also cause cellular stress that activates IFN-α8. Furthermore, compounds that alter intracellular conditions, such as increasing endosomal pH, can impair pathogen replication processes, which can trigger a compensatory activation of IFN-α8.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
R-848 | 144875-48-9 | sc-203231 sc-203231A sc-203231B sc-203231C | 5 mg 25 mg 100 mg 500 mg | $102.00 $306.00 $510.00 $1559.00 | 12 | |
Acts as an agonist at Toll-like receptors 7 and 8, leading to the activation of NF-κB and IRF7, which are transcription factors involved in the upregulation of IFN-α8 expression. | ||||||
Imiquimod | 99011-02-6 | sc-200385 sc-200385A | 100 mg 500 mg | $67.00 $284.00 | 6 | |
TLR7 agonist that triggers a signaling cascade resulting in the activation of transcription factors such as IRF7, enhancing the production and activity of IFN-α8. | ||||||
Polyinosinic acid - polycytidylic acid sodium salt, double-stranded | 42424-50-0 | sc-204854 sc-204854A | 10 mg 100 mg | $139.00 $663.00 | 2 | |
Synthetic analog of double-stranded RNA that engages with TLR3, triggering a signaling pathway that results in the production and activation of IFN-α8. | ||||||
Gardiquimod | 1020412-43-4 | sc-221663 sc-221663A sc-221663B sc-221663C sc-221663D sc-221663E sc-221663F | 25 mg 50 mg 100 mg 250 mg 5 g 10 g 25 g | $157.00 $282.00 $516.00 $1177.00 $20138.00 $32779.00 $70753.00 | 1 | |
Activates TLR7, subsequently enhancing the signaling cascade that induces the expression and functional activity of IFN-α8. | ||||||
Isoprinosine | 36703-88-5 | sc-279232 sc-279232A sc-279232B | 10 mg 100 mg 1 g | $120.00 $210.00 $270.00 | ||
Can enhance the production of various interferons, including IFN-α8, through its effects on immune cells. | ||||||
Fludarabine | 21679-14-1 | sc-204755 sc-204755A | 5 mg 25 mg | $58.00 $204.00 | 15 | |
This nucleotide analog can induce the activation of endogenous RNA sensors, leading to an increase in IFN-α8 expression and activity as part of the antiviral response. | ||||||
Emetine | 483-18-1 | sc-470668 sc-470668A sc-470668B sc-470668C | 1 mg 10 mg 50 mg 100 mg | $440.00 $900.00 $1400.00 $2502.00 | ||
Inhibits protein synthesis at high concentrations, which can cause cellular stress leading to the activation of IFN-α8 through the unfolded protein response. | ||||||
Chloroquine | 54-05-7 | sc-507304 | 250 mg | $69.00 | 2 | |
By increasing endosomal pH, it can impair viral uncoating and replication, resulting in the activation of IFN-α8 as a compensatory antiviral response. | ||||||