IFN-α21 Activators
The chemical class known as IFN-α21 Activators comprises a diverse group of compounds that exert their influence on various cellular pathways and molecular mechanisms to indirectly promote the expression of IFN-α21. These compounds act on signaling pathways involved in immune responses and gene regulation, ultimately leading to the upregulation of IFN-α21 expression.
Retinoic acid activates nuclear receptors, while STAT3 activator and NF-κB activator modulate transcription factors and signaling pathways. JAK inhibitor reduces the negative regulation of IFN-α21, and TLR3 agonist initiates innate immune responses that involve IFN-α21. Elevating cAMP levels with forskolin influences gene expression, and PI3K/Akt activator modulates downstream signaling. p38 MAPK activator and HDAC inhibitor affect epigenetic and kinase-related regulation. TGF-β receptor inhibitor and TNF-α inhibitor counteract suppressive signals, and cGMP elevator influences gene expression through cGMP-responsive elements.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
Retinoic acid activates RAR nuclear receptors, leading to gene expression changes that can induce IFN-α21 transcription. | ||||||
Stat3 inhibitor V, stattic | 19983-44-9 | sc-202818 sc-202818A sc-202818B sc-202818C sc-202818D sc-202818E sc-202818F | 25 mg 100 mg 250 mg 500 mg 1 g 2.5 g 5 g | $130.00 $196.00 $274.00 $512.00 $731.00 $1408.00 $2091.00 | 114 | |
Stattic inhibits STAT3 activation, which can relieve its suppressive effect on IFN-α21 transcription, indirectly promoting IFN-α21 expression. | ||||||
IKK-2 Inhibitor IV | 507475-17-4 | sc-203083 | 500 µg | $133.00 | 12 | |
TPCA-1 activates NF-κB signaling, which can enhance IFN-α21 gene expression by increasing its transcriptional activity. | ||||||
Ruxolitinib | 941678-49-5 | sc-364729 sc-364729A sc-364729A-CW | 5 mg 25 mg 25 mg | $251.00 $500.00 $547.00 | 16 | |
Ruxolitinib inhibits JAKs, and blocking this pathway indirectly elevates IFN-α21 expression by reducing its negative regulation. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin raises intracellular cAMP levels, which can enhance IFN-α21 transcription through cAMP-responsive elements. | ||||||
Anisomycin | 22862-76-6 | sc-3524 sc-3524A | 5 mg 50 mg | $99.00 $259.00 | 36 | |
Anisomycin activates p38 MAPK, which can promote IFN-α21 gene expression by modulating transcription factors and kinases. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $152.00 $479.00 $632.00 $1223.00 $2132.00 | 33 | |
Trichostatin A inhibits HDACs, leading to histone acetylation changes that can favor IFN-α21 transcription. | ||||||
SB 431542 | 301836-41-9 | sc-204265 sc-204265A sc-204265B | 1 mg 10 mg 25 mg | $82.00 $216.00 $416.00 | 48 | |
SB431542 blocks TGF-β receptor signaling, indirectly supporting IFN-α21 expression by inhibiting its suppressive effects. | ||||||
Dibutyryl-cGMP | 51116-00-8 | sc-200321 sc-200321A | 10 mg 50 mg | $153.00 $398.00 | 11 | |
Dibutyryl cGMP increases intracellular cGMP levels, which can modulate IFN-α21 expression via cGMP-responsive elements. | ||||||