IEX-1L Inhibitors
Chemical inhibitors of IEX-1L interfere with various signaling pathways that contribute to the regulation of this protein. SB-203580 operates by targeting p38 MAP kinase, a critical enzyme in the pathway that activates transcription factors for IEX-1L expression. When SB-203580 inhibits p38 MAP kinase, the activation of these transcription factors is decreased, leading to lower expression levels of IEX-1L. Similarly, SP600125 suppresses the activity of IEX-1L by inhibiting c-Jun N-terminal kinase (JNK), another kinase involved in stress-related signaling pathways that affect IEX-1L. LY294002 and Wortmannin both inhibit phosphoinositide 3-kinase (PI3K), a molecule that plays a significant role in the PI3K/Akt signaling pathway, which is known to regulate IEX-1L. The inhibition of PI3K by these chemicals results in reduced activity of downstream signaling components that would normally increase IEX-1L activity.
PD98059 and U0126 are both selective inhibitors of mitogen-activated protein kinase kinase (MEK), which is upstream of extracellular signal-regulated kinases (ERK) implicated in the regulation of IEX-1L. By inhibiting MEK, these chemicals reduce the activation of ERK, subsequently diminishing the functional activity of IEX-1L. Rapamycin, on the other hand, inhibits the mammalian target of rapamycin (mTOR), another key kinase in the PI3K/Akt pathway, resulting in decreased regulation of IEX-1L. PP2 targets Src family kinases, which are part of multiple signaling pathways that intersect with IEX-1L regulation. The action of PP2 leads to a reduction in IEX-1L activity. Stattic, by inhibiting STAT3, affects the transcriptional level of IEX-1L, while NSC 23766 inhibits Rac1, a GTPase that influences the pathways regulating IEX-1L, leading to a decrease in its signaling. Lastly, Triptolide and BAY 11-7082 both target NF-κB, a transcription factor involved in the regulation of IEX-1L. Inhibition of NF-κB by these chemicals results in a decrease in IEX-1L's functional activity.
Items 1 to 10 of 12 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $90.00 $349.00 | 284 | |
This compound inhibits p38 MAP kinase, which is involved in the signaling pathways that control the transcription of IEX-1L. Inhibition of p38 MAP kinase leads to decreased activation of transcription factors that promote IEX-1L expression, thereby functionally inhibiting IEX-1L. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
SP600125 is an inhibitor of c-Jun N-terminal kinase (JNK), which plays a role in stress-activated protein kinase signaling pathways that can regulate IEX-1L. By inhibiting JNK, this chemical can decrease the functional activity of IEX-1L. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
LY294002 is a phosphoinositide 3-kinase (PI3K) inhibitor, where PI3K signaling is known to be involved in the regulation of IEX-1L. By inhibiting PI3K, LY294002 can reduce the activity of downstream effectors that would otherwise contribute to the functional activity of IEX-1L. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $40.00 $92.00 | 212 | |
PD98059 is a selective inhibitor of mitogen-activated protein kinase kinase (MEK), which is upstream of extracellular signal-regulated kinases (ERK) that have been implicated in the regulation of IEX-1L activity. Inhibition of MEK by PD98059 can reduce ERK-mediated functional activity of IEX-1L. | ||||||
U-0126 | 109511-58-2 | sc-222395 sc-222395A | 1 mg 5 mg | $64.00 $246.00 | 136 | |
U0126 is also an inhibitor of MEK, and thus it would function similarly to PD98059 in reducing ERK-mediated functional activity of IEX-1L by inhibiting upstream MEK. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $67.00 $223.00 $425.00 | 97 | |
Wortmannin is another PI3K inhibitor, functioning similarly to LY294002. By inhibiting PI3K, it limits the PI3K/Akt signaling that contributes to the regulation of IEX-1L, thereby reducing its functional activity. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $63.00 $158.00 $326.00 | 233 | |
Rapamycin inhibits the mammalian target of rapamycin (mTOR), a key kinase in the PI3K/Akt pathway. Since mTOR signaling can regulate IEX-1L, inhibition by rapamycin can reduce the functional activity of IEX-1L. | ||||||
PP 2 | 172889-27-9 | sc-202769 sc-202769A | 1 mg 5 mg | $94.00 $227.00 | 30 | |
PP2 is an inhibitor of Src family kinases, which are involved in multiple signaling pathways that can converge on the regulation of IEX-1L. Inhibition of Src kinases by PP2 can decrease the functional activity of IEX-1L. | ||||||
Stat3 inhibitor V, stattic | 19983-44-9 | sc-202818 sc-202818A sc-202818B sc-202818C sc-202818D sc-202818E sc-202818F | 25 mg 100 mg 250 mg 500 mg 1 g 2.5 g 5 g | $130.00 $196.00 $274.00 $512.00 $731.00 $1408.00 $2091.00 | 114 | |
Stattic specifically inhibits STAT3, a transcription factor that can regulate IEX-1L expression. By inhibiting STAT3, Stattic would reduce the functional activity of IEX-1L by reducing its expression. | ||||||
NSC 23766 | 733767-34-5 | sc-204823 sc-204823A | 10 mg 50 mg | $151.00 $609.00 | 75 | |
NSC 23766 inhibits Rac1, a GTPase that can influence pathways regulating IEX-1L. Inhibition of Rac1 can decrease signaling that would otherwise enhance the functional activity of IEX-1L. | ||||||