IDO Inhibitors
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Necrostatin-1 | 4311-88-0 | sc-200142 sc-200142A | 20 mg 100 mg | $94.00 $343.00 | 97 | |
Necrostatin-1 acts as a potent inhibitor of receptor-interacting protein kinase 1 (RIPK1), modulating necroptosis pathways. Its unique structure allows for selective binding to the kinase domain, disrupting ATP binding and altering downstream signaling cascades. The compound exhibits a distinct affinity for specific protein conformations, influencing cellular fate decisions. Its kinetic profile reveals a competitive inhibition mechanism, highlighting its role in regulating cell death and survival pathways. | ||||||
Pyridoxal Isonicotinoyl Hydrazone | 737-86-0 | sc-204192 | 50 mg | $265.00 | 9 | |
Pyridoxal Isonicotinoyl Hydrazone functions as an indoleamine 2,3-dioxygenase (IDO) inhibitor, showcasing unique molecular interactions that disrupt tryptophan catabolism. Its structure facilitates strong binding to the active site of IDO, altering enzyme conformation and inhibiting substrate access. The compound exhibits a distinctive kinetic profile, characterized by non-competitive inhibition, which influences metabolic pathways and immune responses. Its solubility and stability enhance its interaction dynamics within biological systems. | ||||||
Ebselen | 60940-34-3 | sc-200740B sc-200740 sc-200740A | 1 mg 25 mg 100 mg | $33.00 $136.00 $458.00 | 5 | |
Ebselen acts as an indoleamine 2,3-dioxygenase (IDO) inhibitor, exhibiting unique reactivity through its selenoether moiety, which engages in specific interactions with the enzyme's active site. This compound alters the redox state of IDO, leading to a modulation of its catalytic activity. Its kinetic behavior is marked by a reversible inhibition mechanism, allowing for dynamic regulation of tryptophan metabolism. Additionally, Ebselen's lipophilicity enhances its membrane permeability, influencing its interaction with cellular targets. | ||||||
1-Methyl-D-tryptophan | 110117-83-4 | sc-200313 | 50 mg | $52.00 | 3 | |
1-Methyl-D-tryptophan serves as a selective inhibitor of indoleamine 2,3-dioxygenase (IDO), characterized by its unique structural features that facilitate specific binding to the enzyme's active site. This compound disrupts the enzymatic conversion of tryptophan, influencing downstream metabolic pathways. Its distinct steric configuration and electronic properties contribute to its inhibition kinetics, allowing for nuanced modulation of IDO activity and tryptophan availability in biological systems. | ||||||
CAY10581 | 1018340-07-2 | sc-223871 sc-223871A | 1 mg 5 mg | $61.00 $205.00 | 1 | |
CAY10581 functions as an indoleamine 2,3-dioxygenase (IDO) inhibitor, characterized by its unique structural features that facilitate selective binding to the enzyme. The compound exhibits strong hydrophobic interactions and forms critical π-π interactions with aromatic residues, enhancing its inhibitory potency. Its reaction kinetics suggest a non-competitive inhibition model, impacting tryptophan catabolism and modulating downstream metabolic pathways through these specific molecular engagements. | ||||||
Norharmane hydrochloride | 7259-44-1 | sc-253201 sc-253201A | 100 mg 1 g | $33.00 $224.00 | ||
Norharmane hydrochloride acts as an indoleamine 2,3-dioxygenase (IDO) inhibitor, distinguished by its unique indole structure that enhances its affinity for the enzyme. This compound engages in specific hydrogen bonding and π-π stacking interactions, which stabilize its binding to IDO. Its kinetic profile reveals a competitive inhibition mechanism, effectively altering tryptophan metabolism and influencing related biochemical pathways through its distinct molecular interactions. | ||||||
Norharmane | 244-63-3 | sc-212410 sc-212410A sc-212410C sc-212410D sc-212410E sc-212410F | 100 mg 500 mg 1 g 5 g 25 g 50 g | $55.00 $148.00 $245.00 $408.00 $1642.00 $3256.00 | 33 | |
Norharmane acts as an indoleamine 2,3-dioxygenase (IDO) inhibitor, distinguished by its ability to engage in hydrogen bonding and hydrophobic interactions with the enzyme's active site. This compound's unique electronic structure allows for effective π-stacking with nearby aromatic amino acids, influencing its binding affinity. The kinetics of Norharmane reveal a complex interaction profile, suggesting allosteric modulation of IDO activity, thereby altering metabolic flux in tryptophan degradation pathways. | ||||||
INCB024360 | 914471-09-3 | sc-488722 | 25 mg | $300.00 | ||
INCB024360 functions as an indoleamine 2,3-dioxygenase (IDO) inhibitor, characterized by its selective binding to the enzyme's active site through a combination of van der Waals forces and electrostatic interactions. Its unique conformation facilitates a strong fit within the active site, enhancing its inhibitory potency. The compound exhibits a distinct kinetic profile, indicating a competitive inhibition mechanism that effectively disrupts tryptophan metabolism and alters downstream signaling pathways. | ||||||
NLG919 | 1402836-58-1 | sc-478118 | 10 mg | $352.00 | ||
NLG919, also known as BMS-986205, is an inhibitor. By selectively targeting IDO1, NLG919 reduces the production of kynurenine from tryptophan, modulating the local tumor microenvironment. This results in a decrease in immunosuppressive factors and an increase in antitumor immune responses. | ||||||
2-Benzyl-2-thiopseudourea hydrochloride | 538-28-3 | sc-237919 | 100 g | $99.00 | ||
2-Benzyl-2-thiopseudourea hydrochloride acts as a potent indoleamine 2,3-dioxygenase (IDO) inhibitor, showcasing a unique ability to form hydrogen bonds with key amino acid residues in the enzyme's active site. This interaction stabilizes the enzyme-inhibitor complex, leading to a significant reduction in enzymatic activity. The compound's structural features promote a favorable orientation for binding, influencing reaction kinetics and modulating metabolic pathways associated with tryptophan degradation. | ||||||