Date published: 2026-5-9

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IDO Activators

IDO Activators form a distinctive chemical class known for their capacity to modulate the activity of the indoleamine 2,3-dioxygenase (IDO) enzyme. This chemical group functions by interacting with and enhancing the signaling pathways associated with IDO, a key enzyme involved in the catabolism of tryptophan along the kynurenine pathway. IDO plays a crucial role in regulating immune responses, inflammation, and maintaining immune tolerance in various biological contexts.IDO Activators exert their influence through specific molecular interactions that may amplify the downstream effects of IDO-mediated signaling, contributing to the modulation of immune responses, metabolic processes, and the intricate balance between immune activation and regulation. The intricate mechanisms through which IDO Activators impact IDO-related pathways remain an area of ongoing scientific investigation, providing insights into the complex interplay between immune system dynamics and metabolic pathways. The specific ways in which this chemical class engages with IDO underline its significance in unraveling the complexities of immune regulation and enhancing our understanding across various scientific domains.

SEE ALSO...

Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

Dexamethasone

50-02-2sc-29059
sc-29059B
sc-29059A
100 mg
1 g
5 g
$91.00
$139.00
$374.00
36
(1)

While dexamethasone is not typically known to directly induce IDO expression, it can have indirect effects on IDO expression through its broad impact on the immune system.

Cholecalciferol

67-97-0sc-205630
sc-205630A
sc-205630B
1 g
5 g
10 g
$71.00
$163.00
$296.00
2
(1)

Vitamin D has immunomodulatory effects and can induce IDO expression in certain cell types. It contributes to the regulation of immune responses and tolerance.

PGE2

363-24-6sc-201225
sc-201225C
sc-201225A
sc-201225B
1 mg
5 mg
10 mg
50 mg
$57.00
$159.00
$275.00
$678.00
37
(1)

PGE2 is a lipid mediator with immunomodulatory effects. It can induce IDO expression, contributing to immune tolerance and the regulation of immune responses.

Polyinosinic acid - polycytidylic acid sodium salt, double-stranded

42424-50-0sc-204854
sc-204854A
10 mg
100 mg
$139.00
$663.00
2
(1)

Poly(I:C) is a synthetic double-stranded RNA molecule that mimics viral infections. It can stimulate immune cells to express IDO, contributing to immune tolerance during viral responses

Lipopolysaccharide, E. coli O55:B5

93572-42-0sc-221855
sc-221855A
sc-221855B
sc-221855C
10 mg
25 mg
100 mg
500 mg
$98.00
$171.00
$425.00
$1560.00
12
(2)

LPS, a component of bacterial cell walls, can induce IDO expression in certain immune cells. This induction can help regulate immune responses during infections.