Date published: 2026-4-24

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CAY10581 (CAS 1018340-07-2)

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Alternate Names:
(3R,4S)-4-(benzylamino)-3-hydroxy-2,2-dimethyl-3,4-dihydrobenzo[g]chromene-5,10-dione; CAY 10581; CAY-10581
Application:
CAY10581 is a potent indoleamine 2,3-dioxygenase (IDO) inhibitor
CAS Number:
1018340-07-2
Purity:
≥97%
Molecular Weight:
363.41
Molecular Formula:
C22H21NO4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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CAY10581 functions as a selective and potent inhibitor of histone deacetylase (HDAC) enzymes. It exerts its mechanism of action by binding to the active site of HDAC enzymes, thereby preventing the deacetylation of histone proteins. This inhibition leads to an increase in histone acetylation, resulting in altered gene expression and regulation. CAY10581 targets class I HDAC enzymes, such as HDAC1, HDAC2, and HDAC3, without affecting other classes of HDAC enzymes. By modulating histone acetylation, CAY10581 has the potential to influence various cellular processes, including cell cycle regulation, apoptosis, and differentiation. Its mechanism of action at the molecular level may be useful for studying epigenetic regulation and chromatin remodeling in experimental applications.


CAY10581 (CAS 1018340-07-2) References

  1. Clonal analysis of multipotent stromal cells derived from CD271+ bone marrow mononuclear cells: functional heterogeneity and different mechanisms of allosuppression.  |  Kuçi, Z., et al. 2013. Haematologica. 98: 1609-16. PMID: 23975178
  2. Chemical signatures and new drug targets for gametocytocidal drug development.  |  Sun, W., et al. 2014. Sci Rep. 4: 3743. PMID: 24434750
  3. Immunosuppressive monocytes: possible homeostatic mechanism to restrain chronic intestinal inflammation.  |  Kurmaeva, E., et al. 2014. J Leukoc Biol. 96: 377-89. PMID: 24696357
  4. A Clinical Indications Prediction Scale Based on TWIST1 for Human Mesenchymal Stem Cells.  |  Boregowda, SV., et al. 2016. EBioMedicine. 4: 62-73. PMID: 26981553
  5. Mechanisms of Immune Suppression Utilized by Canine Adipose and Bone Marrow-Derived Mesenchymal Stem Cells.  |  Chow, L., et al. 2017. Stem Cells Dev. 26: 374-389. PMID: 27881051
  6. Indoleamine 2,3-dioxygenase 1 (IDO1) inhibitors activate the aryl hydrocarbon receptor.  |  Moyer, BJ., et al. 2017. Toxicol Appl Pharmacol. 323: 74-80. PMID: 28336214
  7. Inhibitors of SARS-CoV-2 main protease: Biological efficacy and toxicity aspects.  |  Viskupicova, J., et al. 2023. Toxicol In Vitro. 92: 105640. PMID: 37419426

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

CAY10581, 1 mg

sc-223871
1 mg
$61.00

CAY10581, 5 mg

sc-223871A
5 mg
$205.00