ICSBP Activators
ICSBP activators, also known as Interferon Consensus Sequence Binding Protein activators, represent a class of molecules with a specific role in regulating gene expression within the context of the immune system. These activators are primarily associated with the modulation of interferon signaling pathways and play a critical role in orchestrating the body's defense against various pathogens, including viruses and intracellular bacteria. ICSBP, also referred to as interferon regulatory factor 8 (IRF8), is a transcription factor that belongs to the interferon regulatory factor (IRF) family. It serves as a pivotal regulator of immune responses by binding to interferon consensus sequences (ICSs) in the promoters of target genes.
ICSBP activators are often small molecules or ligands that can stimulate the transcriptional activity of ICSBP. These activators interact with ICSBP, leading to its increased binding affinity to ICS elements in the DNA. This, in turn, results in the upregulation of specific genes that are critical for the development and function of immune cells, such as dendritic cells, macrophages, and B cells. The activation of ICSBP by these molecules can enhance the production of interferons and other immune mediators, ultimately contributing to a more robust and effective immune response against invading pathogens.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
1α,25-Dihydroxyvitamin D3 | 32222-06-3 | sc-202877B sc-202877A sc-202877C sc-202877D sc-202877 | 50 µg 1 mg 5 mg 10 mg 100 µg | $325.00 $632.00 $1428.00 $2450.00 $400.00 | 32 | |
This active form of vitamin D3 can modulate the immune system. It has been shown to induce the expression of IRF8 in myeloid cells, influencing their differentiation and function, and potentially enhancing the immune response against pathogens. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $65.00 $319.00 $575.00 $998.00 | 28 | |
Retinoic acid, a derivative of vitamin A, is involved in the regulation of immune responses. It can induce the expression of IRF8, influencing the development and function of myeloid cells, and playing a role in the immune response against pathogens. | ||||||
Polyinosinic acid - polycytidylic acid sodium salt, double-stranded | 42424-50-0 | sc-204854 sc-204854A | 10 mg 100 mg | $139.00 $650.00 | 2 | |
Poly(I:C) is a synthetic analog of double-stranded RNA, which can mimic viral infection. It activates the TLR3 and MDA5 pathways, leading to the induction of IRF8 expression in immune cells, and enhancing the antiviral immune response. | ||||||
Imiquimod | 99011-02-6 | sc-200385 sc-200385A | 100 mg 500 mg | $66.00 $278.00 | 6 | |
Imiquimod is a synthetic compound that acts as an immune response modifier. It can activate the TLR7 pathway, leading to the induction of IRF8 expression and the promotion of an antiviral and antitumor immune response. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
Resveratrol is a polyphenolic compound found in grapes and red wine. It has anti-inflammatory and antioxidant properties. Although its direct effect on IRF8 expression is not well documented, it can modulate immune responses and potentially influence the expression of IRF8 indirectly. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $36.00 $68.00 $107.00 $214.00 $234.00 $862.00 $1968.00 | 47 | |
Curcumin is a polyphenolic compound found in turmeric. It has anti-inflammatory and antioxidant properties. Like resveratrol, its direct effect on IRF8 expression is not well established, but it can modulate immune responses, potentially influencing the expression of IRF8 indirectly. | ||||||
D,L-Sulforaphane | 4478-93-7 | sc-207495A sc-207495B sc-207495C sc-207495 sc-207495E sc-207495D | 5 mg 10 mg 25 mg 1 g 10 g 250 mg | $150.00 $286.00 $479.00 $1299.00 $8299.00 $915.00 | 22 | |
Sulforaphane is a compound found in cruciferous vegetables. It has antioxidant and anti-inflammatory properties. While its direct impact on IRF8 expression is not clearly documented, it can modulate immune responses, potentially affecting the expression of IRF8 indirectly. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $30.00 $46.00 $82.00 $218.00 | 19 | |
Sodium butyrate is a short-chain fatty acid produced by bacterial fermentation in the gut. It has anti-inflammatory properties and can modulate immune responses. Its potential to induce IRF8 expression is not well established, but it might influence the expression of IRF8 indirectly through modulation of immune responses. | ||||||
GABA | 56-12-2 | sc-203053 sc-203053A sc-203053B sc-203053C | 10 g 25 g 5 kg 10 kg | $63.00 $133.00 $450.00 $750.00 | 2 | |
GABA is the main inhibitory neurotransmitter in the brain. Recent studies have suggested that GABA can also modulate immune responses. Although its direct effect on IRF8 expression is not clear, it might influence IRF8 expression indirectly through its role in immune modulation. | ||||||