ICEBERG Activators
ICEBERG Activators encompass a collection of chemical entities that serve to indirectly enhance the functional activity of the ICEBERG protein through a variety of signaling pathways. Forskolin, by elevating cyclic AMP levels, indirectly augments ICEBERG's activity by stimulating protein kinase A (PKA), which may phosphorylate substrates that are part of ICEBERG-associated signaling. Genistein, as a tyrosine kinase inhibitor, potentially reduces competitive signaling, thus favoring pathways that ICEBERG is part of, leading to increased functional activity. The lipid signaling molecule sphingosine-1-phosphate may initiate signaling cascades that converge on ICEBERG pathways, and thapsigargin, by increasing intracellular calcium, could activate calcium-dependent pathways that enhance ICEBERG's role. Phorbol 12-myristate 13-acetate (PMA), through PKC activation, and Epigallocatechin gallate (EGCG), as a kinase inhibitor, both have the potential to positively influence pathways that increase the activity of ICEBERG.
The functional activity of ICEBERG is further influenced by compounds that affect various signaling molecules and pathways. Inhibitors such as LY294002 and Wortmannin target PI3K, potentially shifting signaling dynamics to promote pathways in which ICEBERG is involved, thereby enhancing its functional activity. Similarly, SB203580 and U0126, which inhibit p38 MAP kinase and MEK1/2, respectively, may shift the balance of cellular signaling towards ICEBERG activation. A23187 (Calcimycin), through its ionophore action, raises intracellular calcium levels, potentially activating ICEBERG through calcium-dependent signaling pathways. Staurosporine, despite its broad-spectrum kinase inhibition, might selectively enhance the activation of pathways involving ICEBERG by lifting the inhibition exerted by specific kinases on ICEBERG-related processes.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin is a diterpene that activates adenylyl cyclase, leading to an increase in cyclic AMP (cAMP) levels. Elevated cAMP can enhance protein kinase A (PKA) activity which, in turn, could phosphorylate and activate downstream proteins and factors that indirectly enhance ICEBERG function within its specific signaling pathways. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $45.00 $164.00 $200.00 $402.00 $575.00 $981.00 $2031.00 | 46 | |
Genistein is an isoflavone that acts as a tyrosine kinase inhibitor. By inhibiting tyrosine kinases, Genistein may reduce competitive signaling processes, thereby potentially facilitating the signaling pathways in which ICEBERG is involved, leading to its increased functional activity. | ||||||
D-erythro-Sphingosine-1-phosphate | 26993-30-6 | sc-201383 sc-201383D sc-201383A sc-201383B sc-201383C | 1 mg 2 mg 5 mg 10 mg 25 mg | $165.00 $322.00 $570.00 $907.00 $1727.00 | 7 | |
Sphingosine-1-phosphate is a lipid signaling molecule that can activate sphingosine-1-phosphate receptors, leading to downstream signaling cascades that potentially involve ICEBERG activation, enhancing its role in related cellular processes. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $136.00 $446.00 | 114 | |
Thapsigargin is a sesquiterpene lactone that disrupts calcium homeostasis by inhibiting the SERCA pump. This can lead to increased intracellular calcium levels, which may activate calcium-dependent signaling pathways that influence ICEBERG activity. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
PMA is a diester of phorbol and is known to activate protein kinase C (PKC). PKC activation can lead to the phosphorylation of proteins involved in the same pathways as ICEBERG, potentially leading to its indirect activation. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
EGCG is a catechin found in green tea with kinase inhibitory activity. This compound could inhibit kinases that negatively regulate pathways involving ICEBERG, thus enhancing ICEBERG's functional activity by reducing inhibitory signals. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
LY294002 is a specific inhibitor of PI3K. Inhibition of PI3K could lead to alterations in downstream signaling pathways that might involve the functional activation of ICEBERG by changing the signaling dynamics. | ||||||
Wortmannin | 19545-26-7 | sc-3505 sc-3505A sc-3505B | 1 mg 5 mg 20 mg | $67.00 $223.00 $425.00 | 97 | |
Wortmannin is another PI3K inhibitor with a similar mechanism to LY294002, potentially affecting ICEBERG activity through the modulation of PI3K-dependent pathways. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $90.00 $349.00 | 284 | |
SB203580 is a specific inhibitor of p38 MAP kinase. Inhibition of p38 could shift the balance of cellular signaling towards pathways that involve ICEBERG, potentially enhancing its functional activity. | ||||||
A23187 | 52665-69-7 | sc-3591 sc-3591B sc-3591A sc-3591C | 1 mg 5 mg 10 mg 25 mg | $55.00 $131.00 $203.00 $317.00 | 23 | |
A23187 is an ionophore that increases intracellular calcium levels. Elevated calcium can activate numerous calcium-dependent signaling pathways, some of which may enhance the functional activity of ICEBERG. | ||||||