ICEBERG Inhibitors
Chemical inhibitors of ICEBERG act by indirectly affecting the protein's role in inflammatory processes, particularly through the NF-κB signaling pathway and the regulation of inflammasome activity. VX-765 and YVAD-cmk are examples that target the upstream caspase-1, which is crucial for the cleavage of pro-inflammatory cytokines such as IL-1β that ICEBERG helps regulate. By inhibiting caspase-1, these chemicals prevent the activation of the inflammasome, thus indirectly inhibiting the functional role of ICEBERG in the maturation and release of these cytokines. Parthenolide, Bay 11-7082, PDTC, MG-132, QNZ, Wedelolactone, Andrographolide, TPCA-1, BMS-345541, and Sulforaphane constitute a group of chemicals that disrupt the NF-κB pathway at different junctures, which is integral to the expression of pro-inflammatory genes. By doing so, they modulate the activity of ICEBERG within the larger context of its role in immune response.
The specific mechanisms by which these chemicals act on the NF-κB pathway include the inhibition of IκBα phosphorylation (Bay 11-7082), proteasome activity (MG-132), nuclear translocation of NF-κB (QNZ), and IKK complex activity (Wedelolactone, TPCA-1, BMS-345541). Andrographolide and Sulforaphane exert their effects by directly inhibiting the activation of NF-κB. These inhibitors work at different stages of the NF-κB signaling cascade to ensure that the transcriptional activity of NF-κB is suppressed. Since ICEBERG is implicated in the regulation of this pathway, the inhibition of NF-κB by these chemicals results in a decrease in the pro-inflammatory activity that ICEBERG is associated with, thereby functionally inhibiting its role in the immune response.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
VX-765 | 273404-37-8 | sc-475845 sc-475845A sc-475845B | 5 mg 10 mg 50 mg | $224.00 $296.00 $949.00 | 1 | |
VX-765 is a caspase-1 inhibitor that can indirectly inhibit ICEBERG by preventing the cleavage and activation of pro-inflammatory cytokines such as IL-1β, which ICEBERG regulates through its interaction with caspase-1. | ||||||
Caspase-1 Inhibitor II | 178603-78-6 | sc-300323 sc-300323A | 5 mg 25 mg | $255.00 $1224.00 | 7 | |
YVAD-cmk is a tetrapeptide aldehyde that acts as a caspase-1 inhibitor, thereby inhibiting the inflammatory response that ICEBERG is involved in by blocking the activation of the inflammasome and subsequent IL-1β maturation. | ||||||
Parthenolide | 20554-84-1 | sc-3523 sc-3523A | 50 mg 250 mg | $79.00 $300.00 | 32 | |
Parthenolide inhibits the NF-κB pathway, which is crucial for the expression of pro-inflammatory genes that ICEBERG modulates. By suppressing NF-κB, it indirectly inhibits the function of ICEBERG within the inflammasome complex. | ||||||
BAY 11-7082 | 19542-67-7 | sc-200615B sc-200615 sc-200615A | 5 mg 10 mg 50 mg | $61.00 $83.00 $349.00 | 155 | |
Bay 11-7082 is an inhibitor of IκBα phosphorylation, which results in the inhibition of the NF-κB pathway. Since ICEBERG is implicated in inflammation regulation via NF-κB, this chemical can indirectly inhibit its function. | ||||||
Pyrrolidinedithiocarbamic acid ammonium salt | 5108-96-3 | sc-203224 sc-203224A | 5 g 25 g | $32.00 $63.00 | 11 | |
PDTC (Pyrrolidine dithiocarbamate) acts as an NF-κB inhibitor, thus preventing the transcription of genes involved in the inflammatory response, which ICEBERG is known to regulate. | ||||||
MG-132 [Z-Leu- Leu-Leu-CHO] | 133407-82-6 | sc-201270 sc-201270A sc-201270B | 5 mg 25 mg 100 mg | $56.00 $260.00 $980.00 | 163 | |
MG-132 is a proteasome inhibitor that can prevent the degradation of IκB, leading to inhibition of NF-κB activation. As ICEBERG is associated with the regulation of NF-κB activity, MG-132 indirectly inhibits its function. | ||||||
QNZ | 545380-34-5 | sc-200675 | 1 mg | $115.00 | 12 | |
QNZ inhibits NF-κB activation by preventing the nuclear translocation of the NF-κB complex. Through this mechanism, it can indirectly inhibit the function of ICEBERG in immune response modulation. | ||||||
Wedelolactone | 524-12-9 | sc-200648 sc-200648A | 1 mg 5 mg | $108.00 $330.00 | 8 | |
Wedelolactone disrupts the IKK complex, which is necessary for NF-κB activation. By inhibiting this kinase activity, it indirectly affects ICEBERG's role in the NF-κB signaling pathway. | ||||||
Andrographolide | 5508-58-7 | sc-205594 sc-205594A | 50 mg 100 mg | $15.00 $39.00 | 7 | |
Andrographolide is known to inhibit NF-κB activation. Since ICEBERG's function is related to the inflammatory response through NF-κB, andrographolide can inhibit its functional activity indirectly. | ||||||
IKK-2 Inhibitor IV | 507475-17-4 | sc-203083 | 500 µg | $130.00 | 12 | |
TPCA-1 is an inhibitor of IKK-β, which is part of the IKK complex responsible for IκB phosphorylation and NF-κB activation. Inhibiting this kinase can subsequently indirectly inhibit ICEBERG's role in inflammation. | ||||||