iASPP Activators
ORC4 activators constitute a distinctive chemical class known for their ability to modulate the activity of ORC4, a crucial component of the Origin Recognition Complex involved in DNA replication initiation. The exploration of these activators entails a meticulous investigation into the methods governing the activation of ORC4, with a specific focus on unraveling the intricate signaling pathways and molecular interactions influencing its expression. Within this chemical class, researchers have identified specific compounds that can robustly enhance the transcriptional activity of ORC4, employing advanced methodologies to elucidate the nuanced mechanisms underlying its cellular regulation.
Cutting-edge techniques, including structure-activity relationship studies and computational modeling, have played a crucial role in refining our understanding of how ORC4 activators interact with cellular components to influence ORC4 expression. The design and synthesis of these activators have been guided by meticulous strategies to ensure the production of compounds with optimal pharmacokinetic and pharmacodynamic profiles. Additionally, the application of innovative approaches such as high-throughput screening and molecular dynamics simulations has enabled the identification of specific binding sites and conformational changes associated with the activation of ORC4. As research in the field of ORC4 activators progresses, these methodologies continue to contribute to a comprehensive exploration of the regulatory networks governing ORC4 expression, providing valuable insights into the broader cellular processes influenced by the modulation of this key player in DNA replication initiation.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin activates adenylyl cyclase, increasing intracellular cAMP levels. Elevated cAMP activates PKA, which can phosphorylate various targets that may influence iASPP interaction with p53, thereby enhancing the anti-apoptotic function of iASPP. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $149.00 $470.00 $620.00 $1199.00 $2090.00 | 33 | |
Trichostatin A is a histone deacetylase inhibitor. By altering chromatin structure and gene expression, it could upregulate proteins that associate with iASPP, potentially enhancing iASPP's inhibitory effects on apoptotic pathways. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
Resveratrol activates SIRT1, which can deacetylate proteins and influence iASPP's interaction with its partners, promoting its activity in inhibiting apoptosis by possibly strengthening its binding to p53. | ||||||
D-erythro-Sphingosine-1-phosphate | 26993-30-6 | sc-201383 sc-201383D sc-201383A sc-201383B sc-201383C | 1 mg 2 mg 5 mg 10 mg 25 mg | $162.00 $316.00 $559.00 $889.00 $1693.00 | 7 | |
Sphingosine-1-phosphate engages with G-protein-coupled receptors, potentially leading to downstream effects that stabilize iASPP, enhancing its ability to inhibit p53 and thus its role in anti-apoptosis. | ||||||
Zinc | 7440-66-6 | sc-213177 | 100 g | $47.00 | ||
ZnSO4 provides zinc ions, which can stabilize the structure of various proteins. Zinc may particularly stabilize the structure of iASPP, potentially enhancing its inhibitory interaction with p53. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $36.00 $68.00 $107.00 $214.00 $234.00 $862.00 $1968.00 | 47 | |
Curcumin can modulate multiple signaling pathways, including NF-κB, which may have downstream effects on proteins involved in apoptosis. This could indirectly enhance the activity of iASPP by strengthening its anti-apoptotic interactions. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $94.00 $349.00 | 114 | |
Thapsigargin disrupts calcium homeostasis, which can lead to the activation of calcium-dependent signaling pathways that might enhance the stabilization and function of iASPP in inhibiting apoptosis. | ||||||
Caffeine | 58-08-2 | sc-202514 sc-202514A sc-202514B sc-202514C sc-202514D | 5 g 100 g 250 g 1 kg 5 kg | $32.00 $66.00 $95.00 $188.00 $760.00 | 13 | |
Caffeine inhibits phosphodiesterases, leading to increased cAMP levels, which could enhance PKA activity and potentially result in phosphorylation events that promote iASPP anti-apoptotic function. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $121.00 $392.00 | 148 | |
LY294002 is a PI3K inhibitor that can modify the AKT signaling pathway. This alteration may indirectly enhance iASPP's anti-apoptotic activity by affecting the phosphorylation status of proteins that interact with iASPP. | ||||||
PD 98059 | 167869-21-8 | sc-3532 sc-3532A | 1 mg 5 mg | $39.00 $90.00 | 212 | |
PD98059 inhibits MEK, which may lead to altered MAPK pathway activity. The resulting changes in cellular signaling could enhance iASPP's activity by affecting the phosphorylation of proteins that are part of the apoptosis regulation involving iASPP. | ||||||