IARS2 Activators
IARS2 Activators are a class of compounds that influence various signaling pathways or cellular conditions, which can lead to an increased demand for the activity of IARS2, an aminoacyl-tRNA synthetase. These compounds do not directly activate IARS2 but can create a cellular environment where the function of IARS2 is enhanced due to increased protein synthesis or stability requirements.
For instance, the presence of L-Leucine can activate mTOR signaling, a key regulator of protein synthesis, which in turn can increase the functional demand for aminoacyl-tRNA synthetases, including IARS2. This is due to mTOR's role in phosphorylating components of the translation machinery, leading to a higher rate of translation and thus a greater need for the tRNA charging function that IARS2 provides.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
L-Leucine | 61-90-5 | sc-364173 sc-364173A | 25 g 100 g | $21.00 $62.00 | ||
L-Leucine is an amino acid that is known to activate mTOR signaling. mTOR activation enhances protein synthesis by phosphorylating key components of the translation machinery, potentially increasing the demand for IARS2 activity. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin activates adenylate cyclase, increasing cAMP levels and activating PKA. PKA phosphorylation can lead to changes in the translation process, potentially increasing the functional demand for IARS2. | ||||||
Uridine-5′-triphosphate, Trisodium Salt | 19817-92-6 | sc-301964 sc-301964A | 50 mg 1 g | $88.00 $120.00 | 2 | |
UTP, through P2Y receptors, can activate signaling pathways involving calcium mobilization and kinase activation, which can influence translation and, in turn, potentially enhance the functional activity of IARS2. | ||||||
Magnesium chloride | 7786-30-3 | sc-255260C sc-255260B sc-255260 sc-255260A | 10 g 25 g 100 g 500 g | $28.00 $35.00 $48.00 $125.00 | 2 | |
Magnesium is a cofactor required for the proper function of many enzymes, including aminoacyl-tRNA synthetases like IARS2. By stabilizing the structure of ATP, magnesium chloride can enhance the catalytic efficiency of IARS2. | ||||||
Zinc | 7440-66-6 | sc-213177 | 100 g | $48.00 | ||
Zinc acts as a cofactor for many proteins and is known to stabilize the structure of proteins and nucleic acids. Its presence might enhance the structural stability of tRNA, potentially improving the efficiency of IARS2 in tRNA aminoacylation. | ||||||
Sodium selenite | 10102-18-8 | sc-253595 sc-253595B sc-253595C sc-253595A | 5 g 500 g 1 kg 100 g | $49.00 $183.00 $316.00 $98.00 | 3 | |
Selenium is a component of selenoproteins which are involved in antioxidant protection. Its presence can support cellular homeostasis, indirectly supporting processes like translation wherein IARS2 plays a critical role. | ||||||
Insulin | 11061-68-0 | sc-29062 sc-29062A sc-29062B | 100 mg 1 g 10 g | $156.00 $1248.00 $12508.00 | 82 | |
Insulin activates the PI3K/Akt signaling pathway, which can lead to increased protein synthesis and therefore a higher functional demand on IARS2 for proper tRNA aminoacylation. | ||||||
Eicosa-5Z,8Z,11Z,14Z,17Z-pentaenoic Acid (20:5, n-3) | 10417-94-4 | sc-200766 sc-200766A | 100 mg 1 g | $104.00 $431.00 | ||
Eicosapentaenoic acid can modulate inflammatory response and may indirectly affect protein synthesis rates. An increase in protein synthesis could enhance the functional demand for IARS2 activity in cells. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Curcumin can modulate various signaling pathways, including those affecting protein synthesis. By influencing these pathways, it can increase the functional demand for IARS2 activity as part of the cellular response to curcumin. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Resveratrol affects sirtuin activity, which can indirectly lead to modifications in the protein synthesis pathways, potentially increasing the functional demand on IARS2 due to its role in tRNA aminoacylation. | ||||||