Huntingtin Inhibitors
Items 1 to 10 of 11 total
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Polyglutamine Aggregation Inhibitor, PGL-137 | 943-04-4 | sc-204208 | 10 mg | $184.00 | ||
PGL-137 is a specialized compound that targets polyglutamine aggregates, particularly those associated with huntingtin proteins. It engages in specific molecular interactions that stabilize misfolded proteins, preventing their aggregation. The compound exhibits unique binding kinetics, characterized by a high affinity for polyglutamine stretches, which alters the aggregation pathway. Its distinct structural features enhance solubility and promote favorable interactions with cellular chaperones, influencing protein homeostasis. | ||||||
Polyglutamine Aggregation Inhibitor III, C2-8 | 300670-16-0 | sc-202766A sc-202766B sc-202766 sc-202766C | 1 mg 5 mg 10 mg 25 mg | $47.00 $179.00 $312.00 $709.00 | ||
Polyglutamine Aggregation Inhibitor III, C2-8, is a novel compound that disrupts the formation of polyglutamine aggregates linked to huntingtin proteins. It operates through selective binding to the polyglutamine regions, effectively modulating the conformational dynamics of these proteins. The compound's unique structural motifs facilitate enhanced interaction with molecular chaperones, promoting a more favorable protein folding environment. Its kinetic profile suggests a rapid onset of action, influencing aggregation pathways and enhancing cellular resilience against misfolded proteins. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $110.00 $250.00 $936.00 $50.00 | 33 | |
Quercetin, a flavonoid found in many fruits and vegetables, has been studied for its potential to reduce the expression of mutant huntingtin protein and its associated toxic effects. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Curcumin, the active compound in turmeric, has shown promise in reducing huntingtin protein aggregation, a hallmark of Huntington's disease. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
(-)-Epigallocatechin Gallate, a major component of green tea, has been explored for its ability to modulate huntingtin protein expression and mitigate its toxic effects. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $31.00 $47.00 $84.00 $222.00 | 19 | |
Sodium butyrate, a short-chain fatty acid, has demonstrated potential in reducing huntingtin protein aggregation and improving cell survival. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $63.00 $158.00 $326.00 | 233 | |
Rapamycin, an immunosuppressant, has been explored for its potential to decrease huntingtin protein aggregation and improve neuronal survival. | ||||||
17-AAG | 75747-14-7 | sc-200641 sc-200641A | 1 mg 5 mg | $67.00 $156.00 | 16 | |
17-AAG, a Hsp90 inhibitor, has demonstrated potential in reducing huntingtin protein levels and its associated neurodegenerative effects. | ||||||
Salubrinal | 405060-95-9 | sc-202332 sc-202332A | 1 mg 5 mg | $34.00 $104.00 | 87 | |
Salubrinal, a selective inhibitor of eIF2α dephosphorylation, has been studied for its potential to reduce huntingtin protein expression. | ||||||
Caffeine | 58-08-2 | sc-202514 sc-202514A sc-202514B sc-202514C sc-202514D | 50 g 100 g 250 g 1 kg 5 kg | $33.00 $67.00 $97.00 $192.00 $775.00 | 13 | |
Caffeine has been explored for its neuroprotective properties and potential to decrease huntingtin protein aggregation. | ||||||