HSP 40 Activators
The chemical class of HSP 40 activators encompasses a diverse array of compounds that can modulate the activity of Heat Shock Protein 40 (HSP40), a key molecular chaperone involved in protein folding and cellular proteostasis. Geldanamycin and 17-AAG are HSP90 inhibitors that indirectly activate HSP40 by disrupting the HSP90-HSP70-HSP40 chaperone complex, leading to increased client protein binding to HSP70 and HSP40 and activating the heat shock response. Natural compounds like quercetin, withaferin A, celastrol, resveratrol, and epigallocatechin gallate (EGCG) indirectly activate HSP40 by modulating cellular stress response pathways, enhancing the expression and function of HSP40. These compounds, through their antioxidant and anti-inflammatory properties, contribute to the maintenance of protein homeostasis and cellular proteostasis.
Proteasome inhibitor MG-132 indirectly influences HSP40 by promoting the accumulation of misfolded proteins, leading to the upregulation of heat shock proteins, including HSP40, for the clearance and refolding of misfolded proteins. Radicicol, another HSP90 inhibitor, disrupts the HSP90-HSP70-HSP40 chaperone complex, activating the heat shock response and promoting cellular protein homeostasis. 15d-PGJ2, a natural prostaglandin, modulates cellular stress response pathways, leading to the upregulation of HSP40 and supporting cellular proteostasis in response to various stressors. Pifithrin-μ indirectly activates HSP40 by inhibiting the interaction between p53 and HSP70, enhancing the chaperone function of HSP70 in collaboration with HSP40.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Geldanamycin | 30562-34-6 | sc-200617B sc-200617C sc-200617 sc-200617A | 100 µg 500 µg 1 mg 5 mg | $38.00 $58.00 $102.00 $202.00 | 8 | |
Geldanamycin is an HSP90 inhibitor that indirectly influences HSP40 by disrupting the HSP90-HSP70-HSP40 chaperone complex. Inhibition of HSP90 leads to increased client protein binding to HSP70 and HSP40, activating the heat shock response and promoting cellular protein homeostasis. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $108.00 $245.00 $918.00 $49.00 | 33 | |
Quercetin is a natural flavonoid that can indirectly activate HSP40 by modulating cellular stress response pathways. Its antioxidant properties and ability to influence various signaling pathways contribute to the cellular environment, potentially leading to the activation of HSP40 and its chaperone functions. | ||||||
Withaferin A | 5119-48-2 | sc-200381 sc-200381A sc-200381B sc-200381C | 1 mg 10 mg 100 mg 1 g | $127.00 $572.00 $4090.00 $20104.00 | 20 | |
Withaferin A is a natural compound with anti-inflammatory properties that can indirectly activate HSP40. It interacts with cellular stress response pathways, leading to the upregulation of heat shock proteins, including HSP40. The modulation of these pathways can enhance cellular proteostasis and support protein folding. | ||||||
Celastrol, Celastrus scandens | 34157-83-0 | sc-202534 | 10 mg | $155.00 | 6 | |
Celastrol is a triterpenoid with anti-inflammatory properties that indirectly activates HSP40. By modulating cellular stress response pathways, celastrol enhances the expression and function of heat shock proteins, including HSP40. This activation contributes to the maintenance of protein homeostasis and cellular proteostasis. | ||||||
17-AAG | 75747-14-7 | sc-200641 sc-200641A | 1 mg 5 mg | $66.00 $153.00 | 16 | |
17-AAG is an HSP90 inhibitor that indirectly influences HSP40 by disrupting the HSP90-HSP70-HSP40 chaperone complex. Inhibition of HSP90 leads to increased client protein binding to HSP70 and HSP40, activating the heat shock response and promoting cellular protein homeostasis. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
Resveratrol is a natural polyphenol that can indirectly activate HSP40 by influencing cellular stress response pathways. Its antioxidant and anti-inflammatory properties contribute to the modulation of these pathways, leading to the upregulation of heat shock proteins, including HSP40, and supporting cellular proteostasis. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
EGCG, a catechin found in green tea, indirectly activates HSP40 by influencing cellular stress response pathways. Its antioxidant properties and ability to modulate protein folding contribute to the upregulation of heat shock proteins, including HSP40, promoting cellular proteostasis and supporting proper protein folding. | ||||||
MG-132 [Z-Leu- Leu-Leu-CHO] | 133407-82-6 | sc-201270 sc-201270A sc-201270B | 5 mg 25 mg 100 mg | $56.00 $260.00 $980.00 | 163 | |
MG-132 is a proteasome inhibitor that indirectly influences HSP40 by promoting the accumulation of misfolded proteins. The cellular response to proteasome inhibition leads to the upregulation of heat shock proteins, including HSP40, to assist in the clearance and refolding of misfolded proteins, contributing to cellular proteostasis. | ||||||
Radicicol | 12772-57-5 | sc-200620 sc-200620A | 1 mg 5 mg | $90.00 $326.00 | 13 | |
Radicicol is an HSP90 inhibitor that indirectly activates HSP40 by disrupting the HSP90-HSP70-HSP40 chaperone complex. Inhibition of HSP90 leads to increased client protein binding to HSP70 and HSP40, activating the heat shock response and promoting cellular protein homeostasis. | ||||||
15-Deoxy-δ12,14-Prostaglandin J2 | 87893-55-8 | sc-201262 sc-201262A | 1 mg 5 mg | $138.00 $540.00 | 5 | |
15d-PGJ2 is a natural prostaglandin that can indirectly activate HSP40. It modulates cellular stress response pathways, leading to the upregulation of heat shock proteins, including HSP40. This activation contributes to the maintenance of protein homeostasis and supports cellular proteostasis in response to various stressors. | ||||||