HS3ST1 Inhibitors
HS3ST1 inhibitors belong to a class of chemical compounds designed to target and modulate the activity of the heparan sulfate 3-O-sulfotransferase 1 enzyme, commonly abbreviated as HS3ST1. This enzyme plays a critical role in the biosynthesis of heparan sulfate (HS), a complex and highly sulfated polysaccharide found on the cell surface and within the extracellular matrix. HS serves as a vital mediator in various cellular processes, including cell adhesion, growth factor signaling, and interactions with various proteins. Inhibitors of HS3ST1 are developed to interact with this enzyme, potentially interfering with its sulfotransferase activity and impacting the structure and function of heparan sulfate chains.
Typically, HS3ST1 inhibitors are small molecules or compounds designed to bind to the active site of the enzyme, it from catalyzing the 3-O-sulfation of heparan sulfate chains. This inhibition can lead to alterations in the sulfation patterns of heparan sulfate, affecting its ability to interact with specific proteins, growth factors, and extracellular matrix components. Research into HS3ST1 inhibitors can provide valuable insights into the regulation of cellular processes mediated by heparan sulfate, contributing to a better understanding of the roles played by this complex glycosaminoglycan in various physiological and pathological contexts.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Chloroquine | 54-05-7 | sc-507304 | 250 mg | $68.00 | 2 | |
Chloroquine can alkalize lysosomes, potentially affecting the post-translational modification processes necessary for HS3ST1 maturation. | ||||||
Brefeldin A | 20350-15-6 | sc-200861C sc-200861 sc-200861A sc-200861B | 1 mg 5 mg 25 mg 100 mg | $30.00 $52.00 $122.00 $367.00 | 25 | |
This compound disrupts the Golgi apparatus, which could inhibit the processing and trafficking of HS3ST1. | ||||||
Tunicamycin | 11089-65-9 | sc-3506A sc-3506 | 5 mg 10 mg | $169.00 $299.00 | 66 | |
By inhibiting N-linked glycosylation, it may impair the proper folding and function of enzymes like HS3ST1, leading to decreased expression. | ||||||
Cyclosporin A | 59865-13-3 | sc-3503 sc-3503-CW sc-3503A sc-3503B sc-3503C sc-3503D | 100 mg 100 mg 500 mg 10 g 25 g 100 g | $62.00 $90.00 $299.00 $475.00 $1015.00 $2099.00 | 69 | |
This immunosuppressant has been shown to interfere with various cellular proteins; it could theoretically reduce HS3ST1 levels. | ||||||
Mithramycin A | 18378-89-7 | sc-200909 | 1 mg | $54.00 | 6 | |
It binds to GC-rich DNA sequences, potentially blocking the transcription of genes including HS3ST1. | ||||||
Fluorouracil | 51-21-8 | sc-29060 sc-29060A | 1 g 5 g | $36.00 $149.00 | 11 | |
As an antimetabolite, it inhibits nucleotide synthesis, potentially reducing HS3ST1 expression by limiting RNA production. | ||||||
Actinomycin D | 50-76-0 | sc-200906 sc-200906A sc-200906B sc-200906C sc-200906D | 5 mg 25 mg 100 mg 1 g 10 g | $73.00 $238.00 $717.00 $2522.00 $21420.00 | 53 | |
It intercalates into DNA, inhibiting RNA polymerase and potentially reducing the transcription of HS3ST1. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $108.00 $245.00 $918.00 $49.00 | 33 | |
A flavonoid that has been shown to modulate various cellular pathways, which may include the downregulation of HS3ST1 expression. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $65.00 $319.00 $575.00 $998.00 | 28 | |
It regulates gene expression through nuclear receptors, which could affect HS3ST1 transcription. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
This green tea polyphenol is known for its broad biological effects, including potential influence on gene expression profiles. | ||||||