HPV 18-E7 Activators
oncogenic functions of HPV 18-E7 through various cellular signaling pathways and regulatory mechanisms. Ionomycin and Thapsigargin, for example, raise intracellular calcium levels, which activates calcium-dependent kinases that can derail the normal regulatory mechanisms of the cell, complementing HPV 18-E7's capability to degrade tumor suppressor proteins. Other activators, such as Phorbol 12-myristate 13-acetate (PMA) and Bryostatin 1, modulate protein kinase C activity, leading to altered phosphorylation patterns of key proteins in cell cycle regulation, thereby facilitating the ability of HPV 18-E7 to disrupt controlled cell proliferation. Forskolin's elevation of cAMP levels activates PKA, potentially aiding HPV 18-E7 in promoting cell cycle progression from G1 to S phase, whilethe proteasome inhibitor MG132 could create a cellular environment ripe for HPV 18-E7 to further subvert cell cycle checkpoints by causing an accumulation of regulatory proteins.
Activators like Okadaic Acid and Calyculin A inhibit protein phosphatases PP1 and PP2A, maintaining a phosphorylated landscape within the cell that can benefit the activity of HPV 18-E7 in its interference with cell cycle control. Staurosporine, despite its broad kinase inhibition, could paradoxically support the oncogenic activity of HPV 18-E7 by modulating the cellular signaling environment. Epigallocatechin gallate (EGCG) exerts its influence by inhibiting various kinases, potentially shifting signaling pathways to favor the dysregulation of the cell cycle as induced by HPV 18-E7. Retinoic Acid, which affects cell differentiation and proliferation, could inadvertently promote HPV 18-E7's ability to manipulate these cellular processes for its oncogenic purposes. Lastly, the provision of Zinc Sulfate may indirectly bolster the replication of HPV 18-E7-infected cells by ensuring the availability of zinc, a crucial element for DNA synthesis and cell division, thus aiding the viral oncoprotein in its pathogenic activity.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Ionomycin | 56092-82-1 | sc-3592 sc-3592A | 1 mg 5 mg | $76.00 $265.00 | 80 | |
Ionomycin is a calcium ionophore that increases intracellular calcium levels. Elevated calcium can enhance HPV 18-E7 activity as it disrupts cellular regulatory mechanisms, potentially leading to the degradation of tumor suppressor proteins like Rb, which HPV 18-E7 is known to inactivate. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $40.00 $129.00 $210.00 $490.00 $929.00 | 119 | |
PMA is a diacylglycerol analog that activates protein kinase C (PKC). PKC activation can lead to the phosphorylation of proteins involved in cell cycle regulation, potentially facilitating the action of HPV 18-E7 in driving cell proliferation. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $76.00 $150.00 $725.00 $1385.00 $2050.00 | 73 | |
Forskolin elevates intracellular cAMP levels and activates PKA. PKA phosphorylation can lead to changes in cell cycle regulation, complementing the role of HPV 18-E7 in promoting G1 to S phase progression. | ||||||
Okadaic Acid | 78111-17-8 | sc-3513 sc-3513A sc-3513B | 25 µg 100 µg 1 mg | $285.00 $520.00 $1300.00 | 78 | |
Okadaic Acid is a potent inhibitor of protein phosphatases PP1 and PP2A. Inhibition of these phosphatases can prevent dephosphorylation of proteins targeted by HPV 18-E7, thereby maintaining an environment conducive to its oncogenic activity. | ||||||
Calyculin A | 101932-71-2 | sc-24000 sc-24000A | 10 µg 100 µg | $160.00 $750.00 | 59 | |
Similar to Okadaic Acid, Calyculin A is an inhibitor of protein phosphatases PP1 and PP2A. By inhibiting these phosphatases, it could enhance the phosphorylation state of cellular proteins, aiding in the disruption of cell cycle control by HPV 18-E7. | ||||||
Thapsigargin | 67526-95-8 | sc-24017 sc-24017A | 1 mg 5 mg | $94.00 $349.00 | 114 | |
Thapsigargin is a SERCA pump inhibitor that leads to increased intracellular calcium. This can activate calcium-dependent kinases, potentially aiding in the functional activity of HPV 18-E7 in disrupting cell cycle checkpoints. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
EGCG is a polyphenol that can inhibit multiple kinases. By modulating kinase activity, EGCG could shift cellular signaling pathways in a manner that favors the cell cycle dysregulation induced by HPV 18-E7. | ||||||
MG-132 [Z-Leu- Leu-Leu-CHO] | 133407-82-6 | sc-201270 sc-201270A sc-201270B | 5 mg 25 mg 100 mg | $56.00 $260.00 $980.00 | 163 | |
MG132 is a proteasome inhibitor that could lead to the accumulation of cell cycle regulatory proteins. This may create a cellular environment that HPV 18-E7 can exploit to further disrupt normal cell cycle progression. | ||||||
Staurosporine | 62996-74-1 | sc-3510 sc-3510A sc-3510B | 100 µg 1 mg 5 mg | $82.00 $150.00 $388.00 | 113 | |
Staurosporine is a broad-spectrum kinase inhibitor. By inhibiting certain kinases, it may indirectly enhance HPV 18-E7-mediated disruption of cell cycle regulation by altering signaling pathways. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $65.00 $319.00 $575.00 $998.00 | 28 | |
Retinoic Acid affects cell differentiation and proliferation. By influencing these processes, it may enhance the ability of HPV 18-E7 to alter cellular environments in favor of its oncogenic activity. | ||||||