HPV 18-E7 Inhibitors
The Human Papillomavirus (HPV) represents a diverse group of DNA viruses that infect the epithelial cells in humans, leading to various benign and malignant lesions. HPV type 18, alongside a few other types, is predominantly associated with high-risk lesions, particularly in the cervical region. The E7 oncoprotein of HPV 18 (HPV 18-E7) plays a pivotal role in the viral life cycle and oncogenesis. The E7 protein disrupts the normal cell cycle regulation, primarily through its interaction with the retinoblastoma protein (pRb), which eventually leads to the proliferation of infected cells.
HPV 18-E7 inhibitors are a chemical class specifically designed to target and inhibit the function of the E7 oncoprotein. The primary objective of these inhibitors is to interfere with the E7 protein's ability to bind and degrade its cellular targets, thus disrupting the viral life cycle and potentially halting the progression of lesions caused by HPV. These inhibitors can vary in their chemical structures and mechanisms of action, but their primary focus remains the obstruction of E7 functionality. Some inhibitors may directly bind to the E7 protein, preventing its interaction with cellular proteins, while others might target the cellular pathways or proteins that are crucial for E7's action. Given the crucial role of E7 in HPV-associated pathogenesis, the study and development of HPV 18-E7 inhibitors offer a promising avenue for understanding the virus's biology and the molecular basis of its interaction with host cells.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Cisplatin | 15663-27-1 | sc-200896 sc-200896A | 100 mg 500 mg | $138.00 $380.00 | 101 | |
Cisplatin induces DNA cross-linking, leading to DNA damage and potentially counteracting E7's activities. | ||||||
Indole-3-carbinol | 700-06-1 | sc-202662 sc-202662A sc-202662B sc-202662C sc-202662D | 1 g 5 g 100 g 250 g 1 kg | $39.00 $61.00 $146.00 $312.00 $1032.00 | 5 | |
A natural compound found in cruciferous vegetables. Can induce the degradation of the E7 protein. | ||||||
3,3′-Diindolylmethane | 1968-05-4 | sc-204624 sc-204624A sc-204624B sc-204624C sc-204624D sc-204624E | 100 mg 500 mg 5 g 10 g 50 g 1 g | $37.00 $65.00 $89.00 $421.00 $681.00 $66.00 | 8 | |
A derivative of I3C formed in the stomach after consuming cruciferous vegetables. May cause degradation of the E7 protein. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
A yellow pigment found in the turmeric plant. Can inhibit E7 expression and induce apoptosis in HPV-positive cells. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
A major catechin found in green tea. Can lead to the downregulation of E7 and induce apoptosis in HPV-positive cells. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $45.00 $164.00 $200.00 $402.00 $575.00 $981.00 $2031.00 | 46 | |
An isoflavone found in soy products. Can inhibit the phosphorylation of cellular proteins targeted by E7. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
Compounds found in Vitamin A. Can reduce E7 expression and affect cell differentiation. | ||||||
Aspirin | 50-78-2 | sc-202471 sc-202471A | 5 g 50 g | $20.00 $42.00 | 4 | |
Nonsteroidal anti-inflammatory drugs used to reduce inflammation and pain. Some might reduce the expression of E7. | ||||||