Cisplatin CAS: 15663-27-1
MF: Cl2H6N2Pt
Cisplatin is an apoptosis inducer and caspase-3 activator.

Cisplatin (CAS 15663-27-1)

  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getAggregateRating, 138ms
  • REVIEWS, PRODUCT
  • bvseo-msg: The resource to the URL or file is currently unavailable.;
5
2
4
0
3
0
2
0
1
0
Sinonimo: CDDP; cis-Diammineplatinum(II) dichloride
Applicazione: Cisplatin is an apoptosis inducer and caspase-3 activator
Numero CAS: 15663-27-1
Purezza: ≥99%
Peso molecolare: 300.05
Formula molecolare: Cl2H6N2Pt
Supplemental Information: This is classified as a Dangerous Good for transport and may be subject to additional shipping charges.
* Vedere Certificato di Analisi per informazioni sul lotto specifico (incluso il contenuto d'acqua).
Invia una review per questo prodotto e ricevi 15 Cruz Credits

Cisplatin is a potent platinum-based anti-neoplastic agent that is believed to form inter- and intrastrand DNA adducts which activate signaling pathways culminating in apoptosis. The compound has also been shown to induce apoptosis through caspase-3 activation and XIAP expression. Also shown to cause immunosuppression which is thought to be followed by an increase in the host immune response. Platinated DNA adducts also enhance poisoning of DNA topoisomerase I by camptothecin (sc-200871). Cisplatin was the first member of a class of anticancer drugs, which now include carboplatin (sc-202093) and oxaliplatin (sc-202270), that form DNA adducts resulting in apoptosis; however, these molecules also bind other biological molecules such as enzymes which might play a role in their mechanism of action.


Referenze

1. Bagasra, O., et al. 1985. Cancer Immunol. Immunother. 19: 142-147. PMID: 3157438
2. Bose, R.N. 2002. Mini Rev Med Chem. 2: 103-111. PMID: 12370072
3. Siddik, Z.H. 2003. Oncogene. 22: 7265-7279. PMID: 14576837
4. van Waardenburg, R.C., et al. 2004. J. Biol. Chem. 279: 54502-54509. PMID: 15471886

Aspetto :
Powder or crystalline
Stato fisico :
Solid
Solubilità :
Soluble in water (0.25 g/100ml at 25° C), ethanol (<1 mg/ml at 25° C), and DMF (16 mg/ml).
CONSERVAZIONE :
Store at room temperature
Punto di scioglimento :
270° C
Densità :
3.74 g/cm3
Solo per uso in Ricerca. Non previsto per Uso Diagnostico o Terapeutico.
WGK Germania :
3
RTECS :
TP2450000
PubChem CID :
441203
Indice Merck :
14: 2317
Numero MDL :
MFCD00011623
Numero EC :
239-733-8
SMILES :
N.N.Cl[Pt+2]Cl

Download SDS (MSDS)

CERTIFICATO DI ANALISI

Adobe Acrobat Reader necessario per una visualizzazione affidabile,
stampa e commenta sui documenti PDF

Cisplatin  Citazioni prodotti

Vedi quanti altri hanno usato Cisplatin. Clicca sulla voce per laccesso a PubMed .

Ciatazioni 1 a10 di 42 totali

PMID: # 31374291  Li, X.|He, S.|Tian, Y.|Weiss, RM.|Martin, DT.| et al. 2019. Cell. Signal. 63: 109381.

PMID: # 29620162  Yang, X. et al. 2018. Int. J. Oncol. 52: 2021-2030.

PMID: # 29106395  2018. Lab. Invest. 98: 63-78.

PMID: # 28265008  Liu, CW. et al. 2017. Mol. Cancer Ther. 16: 1421-1434.

PMID: # 28692634  Westhoff, GL.|Chen, Y.|Teng, NNH.| et al. 2017. Int. J. Gynecol. Cancer. 27: 1602-1609.

PMID: # 29267289  Chen, Y. et al. 2017. PLoS ONE. 12: e0187222.

PMID: # 29132253  İnci, D. et al. 2017. J. Biomol. Struct. Dyn. 1-24.

PMID: # 28567715  Zhao, H. et al. 2017. Cell Oncol (Dordr). 40: 357-365.

PMID: # 28602975  Kollareddy, M.|Sherrard, A.|Park, JH.|Szemes, M.|Gallacher, K.|Melegh, Z.|Oltean, S.|Michaelis, M.|Cinatl, J.|Kaidi, A.|Malik, K.| et al. 2017. Cancer Lett. 403: 74-85.

PMID: # 28339648  Pendergraft, SS. et al. 2017. Biol. Reprod. 96: 720-732.

Ciatazioni 1 a10 di 42 totali
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getContent, 156ms
  • QUESTIONS, PRODUCT
  • bvseo-msg: The resource to the URL or file is currently unavailable.;
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getReviews, 9ms
  • REVIEWS, PRODUCT
  • bvseo-msg: The resource to the URL or file is currently unavailable.;

La Santa Cruz Biotechnology, Inc. è un leader mondiale nello sviluppo di prodotti per il mercato della ricerca biomedica. Chiamaci al numero gratuito 1-800-457-3801.
Copyright © 2007-2020 Santa Cruz Biotechnology, Inc. Tutti i diritti riservati. "Santa Cruz Biotechnology", ed il logo Santa Cruz Biotechnology, Inc."Santa Cruz Animal Health", "San Juan Ranch", "Supplement of Champions", il logo San Juan Ranch, "Ultracruz", "Chemcruz", "Immunocruz", "Exactacruz", ed "EZ Touch" sono marchi registrati dalla Santa Cruz Biotechnology, Inc.
Tutti i marchi sono proprietà dei rispettivi proprietari.