HPS-5 Activators
Hermansky-Pudlak Syndrome 5 (HPS-5) is a protein that plays a critical role in the biogenesis of lysosome-related organelles, a process essential for the correct functioning of cellular components such as melanosomes, platelet-dense granules, and lysosomes. The gene responsible for encoding HPS-5, HPS5, is part of a group of genes associated with Hermansky-Pudlak syndrome, a disorder that presents with manifestations including oculocutaneous albinism and lysosomal storage issues. Research into HPS-5 has revealed its involvement in the trafficking of proteins to lysosome-related organelles, and any alteration in its expression can have profound effects on cellular homeostasis and organelle function.
In the study of HPS-5, various chemical compounds have been identified that could potentially influence the expression levels of this protein. These activators are utilized in research as tools to understand the complex regulatory mechanisms governing gene expression. Compounds such as curcumin and resveratrol are known to elevate the expression of certain genes by activating transcription factors or modulating cellular signaling pathways. Flavonoids like quercetin and isoflavones such as genistein could stimulate the expression of HPS-5 by engaging with cellular defense mechanisms against environmental stresses. Other compounds with potential activity include sulforaphane, which may induce gene expression via the Keap1-Nrf2 pathway, and retinoic acid, which can influence gene expression related to cellular differentiation and organogenesis. Substances that mimic nutrient deprivation, such as 2-deoxy-D-glucose, might also initiate cellular pathways that ultimately lead to the elevated expression of HPS-5. Understanding how these activators work can provide valuable insights into the regulation of HPS-5 and the maintenance of lysosomal function, which is crucial for the overall health and balance of cellular processes.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $36.00 $68.00 $107.00 $214.00 $234.00 $862.00 $1968.00 | 47 | |
Curcumin can upregulate HPS-5 by activating transcription factors such as NF-κB, which are known to play a role in the cellular response to oxidative stress and inflammation, potentially leading to increased expression of protective genes like HPS-5. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $60.00 $185.00 $365.00 | 64 | |
Resveratrol may stimulate the expression of HPS-5 by enhancing the activity of longevity-associated sirtuins, which could initiate a cascade of gene expression changes aimed at promoting cellular survival and homeostasis. | ||||||
Quercetin | 117-39-5 | sc-206089 sc-206089A sc-206089E sc-206089C sc-206089D sc-206089B | 100 mg 500 mg 100 g 250 g 1 kg 25 g | $11.00 $17.00 $108.00 $245.00 $918.00 $49.00 | 33 | |
Quercetin has the capacity to elevate HPS-5 levels by counteracting oxidative stress, thereby potentially prompting a defensive response in cells that includes bolstering the lysosomal function through increased expression of HPS-5. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $26.00 $92.00 $120.00 $310.00 $500.00 $908.00 $1821.00 | 46 | |
Genistein could stimulate HPS-5 expression by binding to estrogen receptors and activating genes involved in the endosomal sorting complex required for transport (ESCRT) machinery, which is necessary for the biogenesis of lysosome-related organelles. | ||||||
D,L-Sulforaphane | 4478-93-7 | sc-207495A sc-207495B sc-207495C sc-207495 sc-207495E sc-207495D | 5 mg 10 mg 25 mg 1 g 10 g 250 mg | $150.00 $286.00 $479.00 $1299.00 $8299.00 $915.00 | 22 | |
DL-Sulforaphane may induce HPS-5 by triggering the Keap1-Nrf2 pathway, leading to the transcriptional activation of genes that govern cellular defense mechanisms against electrophiles and oxidative stress. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $42.00 $72.00 $124.00 $238.00 $520.00 $1234.00 | 11 | |
Epigallocatechin Gallate might enhance HPS-5 expression via the activation of cellular pathways related to the unfolded protein response, which is a part of the endoplasmic reticulum stress response, thus potentially leading to increased expression of genes that facilitate cellular repair processes. | ||||||
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $65.00 $319.00 $575.00 $998.00 | 28 | |
Retinoic Acid could increase HPS-5 by serving as a ligand for retinoic acid receptors, which upon activation, may induce a range of genes involved in cellular differentiation, including those that contribute to organelle biogenesis. | ||||||
2-Deoxy-D-glucose | 154-17-6 | sc-202010 sc-202010A | 1 g 5 g | $65.00 $210.00 | 26 | |
2-Deoxy-D-glucose can induce HPS-5 expression by mimicking a state of nutrient deprivation, thus initiating autophagic pathways and potentially enhancing the expression of genes involved in lysosomal function and biogenesis. | ||||||
D-(+)-Trehalose Anhydrous | 99-20-7 | sc-294151 sc-294151A sc-294151B | 1 g 25 g 100 g | $29.00 $164.00 $255.00 | 2 | |
Trehalose might upregulate HPS-5 by promoting autophagy through the activation of transcription factor EB (TFEB), a master regulator of lysosome biogenesis and function, thereby stimulating the expression of genes necessary for this process. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Lithium can stimulate HPS-5 expression by acting on glycogen synthase kinase-3 (GSK-3), an enzyme involved in numerous signaling pathways, including those that govern the expression of genes related to neuroprotection and cellular resilience. | ||||||