HPR inhibitors belong to a specific category of chemical compounds designed to target and inhibit the activity of the HPR protein, also known as Hypoxia-upregulated Protein. HPR is a protein that has been associated with various cellular processes and is particularly noteworthy for its regulation in response to low oxygen levels, a condition known as hypoxia. Hypoxia is a critical factor in the context of several physiological and pathological processes, including embryonic development, wound healing, and tumor growth. HPR is thought to play roles in cell survival, proliferation, and adaptation to hypoxic environments. Inhibitors of HPR are primarily developed for research purposes, serving as valuable tools for scientists and researchers to investigate the molecular mechanisms and functions associated with this protein in the context of hypoxia-related cellular responses.
HPR inhibitors are typically composed of small molecules or chemical compounds specifically designed to interact with the HPR protein, disrupting its normal function. By inhibiting HPR, these compounds can potentially interfere with the cellular responses to hypoxia, which may include changes in gene expression, cell survival pathways, and angiogenesis. Researchers use HPR inhibitors in laboratory settings to manipulate the activity of this protein and study its roles in hypoxic adaptation and cellular responses to low oxygen levels. These inhibitors provide valuable insights into the molecular mechanisms by which HPR influences cellular processes in hypoxic conditions and contribute to a deeper understanding of its significance in cellular biology, particularly in the context of hypoxia-related adaptations. While HPR inhibitors may have broader implications, their primary purpose is to assist scientists in deciphering the intricacies of HPR-mediated cellular responses to hypoxia.
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Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
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Actinomycin D | 50-76-0 | sc-200906 sc-200906A sc-200906B sc-200906C sc-200906D | 5 mg 25 mg 100 mg 1 g 10 g | $73.00 $238.00 $717.00 $2522.00 $21420.00 | 53 | |
Actinomycin D binds to DNA and inhibits RNA polymerase, potentially decreasing HPR gene transcription. | ||||||
Cycloheximide | 66-81-9 | sc-3508B sc-3508 sc-3508A | 100 mg 1 g 5 g | $40.00 $82.00 $256.00 | 127 | |
Cycloheximide blocks translation elongation in eukaryotes, possibly reducing HPR protein synthesis. | ||||||
Doxorubicin | 23214-92-8 | sc-280681 sc-280681A | 1 mg 5 mg | $173.00 $418.00 | 43 | |
Doxorubicin intercalates into DNA and disrupts topoisomerase-II, which could affect HPR expression due to DNA damage responses. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $149.00 $470.00 $620.00 $1199.00 $2090.00 | 33 | |
Trichostatin A is a histone deacetylase inhibitor, potentially altering gene expression including HPR. | ||||||
Rifampicin | 13292-46-1 | sc-200910 sc-200910A sc-200910B sc-200910C | 1 g 5 g 100 g 250 g | $95.00 $322.00 $663.00 $1438.00 | 6 | |
Rifampicin can inhibit bacterial RNA polymerase, and at high concentrations, it may also affect eukaryotic cells and potentially HPR expression. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $30.00 $46.00 $82.00 $218.00 | 19 | |
Sodium butyrate acts as a histone deacetylase inhibitor, which could influence chromatin structure and HPR gene expression. | ||||||
Chloroquine | 54-05-7 | sc-507304 | 250 mg | $68.00 | 2 | |
Chloroquine disrupts lysosomal function and autophagy, potentially affecting HPR expression through altered cellular homeostasis. | ||||||
MG-132 [Z-Leu- Leu-Leu-CHO] | 133407-82-6 | sc-201270 sc-201270A sc-201270B | 5 mg 25 mg 100 mg | $56.00 $260.00 $980.00 | 163 | |
MG-132 inhibits proteasomes and can induce ER stress, potentially affecting HPR expression as part of the unfolded protein response. | ||||||
Etoposide (VP-16) | 33419-42-0 | sc-3512B sc-3512 sc-3512A | 10 mg 100 mg 500 mg | $32.00 $170.00 $385.00 | 63 | |
Etoposide inhibits topoisomerase II, potentially causing DNA damage and affecting HPR expression as a cellular response. | ||||||
Mithramycin A | 18378-89-7 | sc-200909 | 1 mg | $54.00 | 6 | |
Mithramycin A binds to DNA, affecting transcription factors and potentially decreasing HPR gene expression. |