Date published: 2025-10-11

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HPR Inhibitors

HPR inhibitors belong to a specific category of chemical compounds designed to target and inhibit the activity of the HPR protein, also known as Hypoxia-upregulated Protein. HPR is a protein that has been associated with various cellular processes and is particularly noteworthy for its regulation in response to low oxygen levels, a condition known as hypoxia. Hypoxia is a critical factor in the context of several physiological and pathological processes, including embryonic development, wound healing, and tumor growth. HPR is thought to play roles in cell survival, proliferation, and adaptation to hypoxic environments. Inhibitors of HPR are primarily developed for research purposes, serving as valuable tools for scientists and researchers to investigate the molecular mechanisms and functions associated with this protein in the context of hypoxia-related cellular responses.

HPR inhibitors are typically composed of small molecules or chemical compounds specifically designed to interact with the HPR protein, disrupting its normal function. By inhibiting HPR, these compounds can potentially interfere with the cellular responses to hypoxia, which may include changes in gene expression, cell survival pathways, and angiogenesis. Researchers use HPR inhibitors in laboratory settings to manipulate the activity of this protein and study its roles in hypoxic adaptation and cellular responses to low oxygen levels. These inhibitors provide valuable insights into the molecular mechanisms by which HPR influences cellular processes in hypoxic conditions and contribute to a deeper understanding of its significance in cellular biology, particularly in the context of hypoxia-related adaptations. While HPR inhibitors may have broader implications, their primary purpose is to assist scientists in deciphering the intricacies of HPR-mediated cellular responses to hypoxia.

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Items 1 to 10 of 11 total

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Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

Actinomycin D

50-76-0sc-200906
sc-200906A
sc-200906B
sc-200906C
sc-200906D
5 mg
25 mg
100 mg
1 g
10 g
$73.00
$238.00
$717.00
$2522.00
$21420.00
53
(3)

Actinomycin D binds to DNA and inhibits RNA polymerase, potentially decreasing HPR gene transcription.

Cycloheximide

66-81-9sc-3508B
sc-3508
sc-3508A
100 mg
1 g
5 g
$40.00
$82.00
$256.00
127
(5)

Cycloheximide blocks translation elongation in eukaryotes, possibly reducing HPR protein synthesis.

Doxorubicin

23214-92-8sc-280681
sc-280681A
1 mg
5 mg
$173.00
$418.00
43
(3)

Doxorubicin intercalates into DNA and disrupts topoisomerase-II, which could affect HPR expression due to DNA damage responses.

Trichostatin A

58880-19-6sc-3511
sc-3511A
sc-3511B
sc-3511C
sc-3511D
1 mg
5 mg
10 mg
25 mg
50 mg
$149.00
$470.00
$620.00
$1199.00
$2090.00
33
(3)

Trichostatin A is a histone deacetylase inhibitor, potentially altering gene expression including HPR.

Rifampicin

13292-46-1sc-200910
sc-200910A
sc-200910B
sc-200910C
1 g
5 g
100 g
250 g
$95.00
$322.00
$663.00
$1438.00
6
(1)

Rifampicin can inhibit bacterial RNA polymerase, and at high concentrations, it may also affect eukaryotic cells and potentially HPR expression.

Sodium Butyrate

156-54-7sc-202341
sc-202341B
sc-202341A
sc-202341C
250 mg
5 g
25 g
500 g
$30.00
$46.00
$82.00
$218.00
19
(3)

Sodium butyrate acts as a histone deacetylase inhibitor, which could influence chromatin structure and HPR gene expression.

Chloroquine

54-05-7sc-507304
250 mg
$68.00
2
(0)

Chloroquine disrupts lysosomal function and autophagy, potentially affecting HPR expression through altered cellular homeostasis.

MG-132 [Z-Leu- Leu-Leu-CHO]

133407-82-6sc-201270
sc-201270A
sc-201270B
5 mg
25 mg
100 mg
$56.00
$260.00
$980.00
163
(3)

MG-132 inhibits proteasomes and can induce ER stress, potentially affecting HPR expression as part of the unfolded protein response.

Etoposide (VP-16)

33419-42-0sc-3512B
sc-3512
sc-3512A
10 mg
100 mg
500 mg
$32.00
$170.00
$385.00
63
(1)

Etoposide inhibits topoisomerase II, potentially causing DNA damage and affecting HPR expression as a cellular response.

Mithramycin A

18378-89-7sc-200909
1 mg
$54.00
6
(1)

Mithramycin A binds to DNA, affecting transcription factors and potentially decreasing HPR gene expression.