HoxD9 Activators
HoxD9 is a member of the Homeobox (Hox) gene family, which encodes transcription factors that are critical for embryonic development and the determination of the body plan. These transcription factors, including HoxD9, bind to DNA and regulate the expression of genes involved in morphogenesis and the development of limbs and organs. HoxD9 Activators, as a chemical class, are compounds that can either directly or indirectly stimulate the transcriptional activity of HoxD9.
Direct HoxD9 Activators are capable of interacting with the HoxD9 protein in a way that enhances its ability to bind DNA and activate gene transcription. This can occur through a variety of mechanisms, such as altering the protein's conformation to a state that has a higher affinity for specific DNA sequences, or by stabilizing the interaction between HoxD9 and its co-factors, which are often necessary for efficient transcription. The activators could bind to the HoxD9 protein at a site that is distinct from the DNA-binding domain, which is a strategy to avoid competition with DNA for binding and allows the activator to exert its influence in a non-competitive manner. Indirect HoxD9 Activators would work by influencing the cellular environment or signaling pathways that modulate HoxD9 activity. These might include small molecules that upregulate the expression of the HoxD9 gene itself, thereby increasing the amount of the HoxD9 protein in the cell. Other indirect activators may inhibit negative regulators of HoxD9, such as proteins that bind to HoxD9 and repress its ability to activate transcription. Additionally, indirect activators may affect the modification of HoxD9 or its co-factors, such as phosphorylation, acetylation, or methylation, which can impact the activity and stability of the transcription factor.
SEE ALSO...
Items 1 to 10 of 11 total
Display:
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $65.00 $319.00 $575.00 $998.00 | 28 | |
Retinoic acid is a metabolite of vitamin A that can regulate gene expression. It is known to induce the expression of Hox genes, including HoxD9, by directly binding to retinoic acid receptors, which then interact with retinoic acid response elements in the promoters of Hox genes. This can result in the transcriptional activation and increased functional activity of HoxD9. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
5-Azacytidine is a DNA methyltransferase inhibitor. It can reactivate the expression of HoxD9 by reducing DNA methylation in its promoter region, resulting in the enhanced functional activity of HoxD9. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $149.00 $470.00 $620.00 $1199.00 $2090.00 | 33 | |
Trichostatin A is a histone deacetylase inhibitor. It can increase the acetylation of histones in the promoter region of HoxD9, leading to a more accessible chromatin structure and increased expression and functional activity of HoxD9. | ||||||
Valproic Acid | 99-66-1 | sc-213144 | 10 g | $85.00 | 9 | |
Valproic acid is another histone deacetylase inhibitor. By increasing histone acetylation in the promoter region of HoxD9, it can enhance the expression and functional activity of HoxD9. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $30.00 $46.00 $82.00 $218.00 | 19 | |
Sodium butyrate is a short-chain fatty acid that inhibits histone deacetylases. It can increase histone acetylation and reduce chromatin compaction at the HoxD9 locus, enhancing the transcription and functional activity of HoxD9. | ||||||
Suberoylanilide Hydroxamic Acid | 149647-78-9 | sc-220139 sc-220139A | 100 mg 500 mg | $130.00 $270.00 | 37 | |
Vorinostat is a histone deacetylase inhibitor. It can enhance HoxD9 transcription and functional activity by increasing histone acetylation in the HoxD9 promoter region. | ||||||
Genistein | 446-72-0 | sc-3515 sc-3515A sc-3515B sc-3515C sc-3515D sc-3515E sc-3515F | 100 mg 500 mg 1 g 5 g 10 g 25 g 100 g | $26.00 $92.00 $120.00 $310.00 $500.00 $908.00 $1821.00 | 46 | |
Genistein is a tyrosine kinase inhibitor. It can alter the phosphorylation state of proteins involved in the transcriptional regulation of HoxD9, leading to enhanced expression and functional activity of HoxD9. | ||||||
5-Aza-2′-Deoxycytidine | 2353-33-5 | sc-202424 sc-202424A sc-202424B | 25 mg 100 mg 250 mg | $214.00 $316.00 $418.00 | 7 | |
Decitabine is a DNA methyltransferase inhibitor. It can enhance HoxD9 expression and functional activity by reducing DNA methylation in the HoxD9 promoter region. | ||||||
Romidepsin | 128517-07-7 | sc-364603 sc-364603A | 1 mg 5 mg | $214.00 $622.00 | 1 | |
Romidepsin is a histone deacetylase inhibitor. It can enhance HoxD9 transcription and functional activity by increasing histone acetylation in the HoxD9 promoter region. | ||||||
Panobinostat | 404950-80-7 | sc-208148 | 10 mg | $196.00 | 9 | |
Panobinostat is a histone deacetylase inhibitor. It can increase histone acetylation in the HoxD9 gene promoter region, enhancing HoxD9 transcription and functional activity. | ||||||