HoxD9 Antibody (H-2): sc-137134
- HoxD9 Antibody (H-2) is a mouse monoclonal IgG1 κ HoxD9 antibody, cited in 3 publications, provided at 200 µg/ml
- specific for an epitope mapping between amino acids 27-58 near the N-terminus of HoxD9 of human origin
- HoxD9 Antibody (H-2) is recommended for detection of HoxD9 of mouse, rat and human origin by WB, IP, IF and ELISA
- Anti-HoxD9 Antibody (H-2) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- TransCruz reagent for ChIP application (sc-137134 X, 200 µg/0.1 ml)
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for HoxD9 Antibody (H-2). This work is in progress.
HoxD9 Antibody (H-2) is a mouse monoclonal IgG1 kappa light chain antibody that detects HoxD9 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). anti-HoxD9 antibody (H-2) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. HoxD9 plays a crucial role in embryonic development and cellular differentiation by regulating downstream target genes, which is vital for proper organ and limb formation. Specifically, HoxD9 is involved in the early stages of joint development, where HoxD9 is primarily expressed in articular cartilage, and HoxD9 expression is notably elevated in the synovial tissue of arthritic mice compared to normal mice, indicating a potential role in the pathology of arthritis. Furthermore, HoxD9 interacts with the human control region of the HoxD9 gene, enhancing transcription and suggesting a function as a multifunctional transcriptional regulator with various activation domains. Notably, HoxD9 is differentially expressed in the human cervical cancer cell line HeLa, but absent in normal cervical tissue, hinting at involvement in tumorigenesis. HoxD9′s ability to modulate gene expression through structural characteristics and interactions with regulatory elements underscores importance in both developmental biology and disease processes.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
HoxD9 Antibody (H-2) References:
- Expression of murine HOXD9 during embryonic joint patterning and in human T lymphotropic virus type I tax transgenic mice with arthropathy resembling rheumatoid arthritis. | Khoa, ND., et al. 1999. Arthritis Rheum. 42: 686-96. PMID: 10211882
- Potential role of HOXD9 in synoviocyte proliferation. | Khoa, ND., et al. 2001. Arthritis Rheum. 44: 1013-21. PMID: 11352232
- Expression of homeobox genes in cervical cancer. | Li, H., et al. 2002. Gynecol Oncol. 84: 216-21. PMID: 11812077
- Specificity of HOX protein function depends on DNA-protein and protein-protein interactions, both mediated by the homeo domain. | Zappavigna, V., et al. 1994. Genes Dev. 8: 732-44. PMID: 7926763
- Definition of the transcriptional activation domains of three human HOX proteins depends on the DNA-binding context. | Viganò, MA., et al. 1998. Mol Cell Biol. 18: 6201-12. PMID: 9774637
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
HoxD9 Antibody (H-2) | sc-137134 | 200 µg/ml | $322.00 | |||
HoxD9 Antibody (H-2) X | sc-137134 X | 200 µg/0.1 ml | $322.00 | |||
HoxD9 Antibody (H-2) AC | sc-137134 AC | 500 µg/ml, 25% agarose | $424.00 | |||
HoxD9 Antibody (H-2) HRP | sc-137134 HRP | 200 µg/ml | $322.00 | |||
HoxD9 Antibody (H-2) FITC | sc-137134 FITC | 200 µg/ml | $336.00 | |||
HoxD9 Antibody (H-2) PE | sc-137134 PE | 200 µg/ml | $349.00 | |||
HoxD9 Antibody (H-2) Alexa Fluor® 488 | sc-137134 AF488 | 200 µg/ml | $364.00 | |||
HoxD9 Antibody (H-2) Alexa Fluor® 546 | sc-137134 AF546 | 200 µg/ml | $364.00 | |||
HoxD9 Antibody (H-2) Alexa Fluor® 594 | sc-137134 AF594 | 200 µg/ml | $364.00 | |||
HoxD9 Antibody (H-2) Alexa Fluor® 647 | sc-137134 AF647 | 200 µg/ml | $364.00 | |||
HoxD9 Antibody (H-2) Alexa Fluor® 680 | sc-137134 AF680 | 200 µg/ml | $364.00 | |||
HoxD9 Antibody (H-2) Alexa Fluor® 790 | sc-137134 AF790 | 200 µg/ml | $364.00 | |||
HoxD9 (H-2) Neutralizing Peptide | sc-137134 P | 100 µg/0.5 ml | $69.00 |