HoxA7 inhibitors belong to a specialized class of chemical compounds that have gained significance in the field of molecular biology and developmental genetics. HoxA7, part of the Hox gene family, is a transcription factor known for its crucial role in embryonic development and pattern formation. The Hox genes are a highly conserved group of genes that regulate the spatial organization of body structures along the anterior-posterior axis during embryogenesis. HoxA7, in particular, is involved in specifying the identity of cells along this axis, ensuring that structures and tissues develop in the appropriate locations. HoxA7 inhibitors are chemical compounds designed to interact with HoxA7, potentially modulating its transcriptional activity and influencing the developmental processes it regulates.
The mechanism of action of HoxA7 inhibitors typically involves their binding to specific regions or domains within the HoxA7 protein. This interaction can lead to changes in HoxA7's ability to bind to its target genes' regulatory regions, thereby affecting its capacity to activate or repress gene expression. Consequently, HoxA7 inhibitors may have implications for various developmental processes, such as limb formation, organ development, and axial patterning, offering insights into the molecular mechanisms that govern embryonic development and tissue differentiation. The study of HoxA7 inhibitors is essential in advancing our understanding of the intricate regulatory networks that guide embryogenesis, providing valuable tools for investigating the roles of Hox genes like HoxA7 in various developmental contexts and their contributions to the establishment of body plan and structure.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
5-Aza-2′-Deoxycytidine | 2353-33-5 | sc-202424 sc-202424A sc-202424B | 25 mg 100 mg 250 mg | $214.00 $316.00 $418.00 | 7 | |
Decitabine is a DNA methyltransferase inhibitor that can lead to gene reactivation by demethylation but may also indirectly inhibit gene expression. | ||||||
Suberoylanilide Hydroxamic Acid | 149647-78-9 | sc-220139 sc-220139A | 100 mg 500 mg | $130.00 $270.00 | 37 | |
Vorinostat inhibits histone deacetylases, altering chromatin structure and potentially decreasing specific gene expression, such as HoxA7. | ||||||
MS-275 | 209783-80-2 | sc-279455 sc-279455A sc-279455B | 1 mg 5 mg 25 mg | $24.00 $88.00 $208.00 | 24 | |
Entinostat is a selective histone deacetylase inhibitor that can change gene expression profiles, possibly affecting HoxA7 levels. | ||||||
BIX01294 hydrochloride | 1392399-03-9 | sc-293525 sc-293525A sc-293525B | 1 mg 5 mg 25 mg | $36.00 $110.00 $400.00 | ||
BIX-01294 is a G9a histone methyltransferase inhibitor, potentially altering chromatin marks and gene expression, including that of HoxA7. | ||||||
RG 108 | 48208-26-0 | sc-204235 sc-204235A | 10 mg 50 mg | $128.00 $505.00 | 2 | |
RG108 is a DNA methyltransferase inhibitor that does not cause DNA damage, potentially affecting DNA methylation status and gene expression. | ||||||
Zebularine | 3690-10-6 | sc-203315 sc-203315A sc-203315B | 10 mg 25 mg 100 mg | $126.00 $278.00 $984.00 | 3 | |
Zebularine is a cytidine analog that inhibits DNA methyltransferase, potentially leading to altered expression of genes such as HoxA7. | ||||||
Disulfiram | 97-77-8 | sc-205654 sc-205654A | 50 g 100 g | $52.00 $87.00 | 7 | |
Disulfiram can modulate DNA methyltransferase activity, potentially influencing the expression of genes like HoxA7. | ||||||
Parthenolide | 20554-84-1 | sc-3523 sc-3523A | 50 mg 250 mg | $79.00 $300.00 | 32 | |
Parthenolide may affect NF-kB signaling and other transcriptional regulators, potentially modifying the expression of certain genes. | ||||||
Thiostrepton | 1393-48-2 | sc-203412 sc-203412A | 1 g 5 g | $115.00 $415.00 | 10 | |
Thiostrepton inhibits FOXM1, a transcription factor involved in cell cycle regulation, potentially affecting HoxA7 expression indirectly. | ||||||
Mithramycin A | 18378-89-7 | sc-200909 | 1 mg | $54.00 | 6 | |
Plicamycin binds to DNA and inhibits RNA synthesis, which can include the transcription of genes such as HoxA7. | ||||||