HoxA7 Antibody (743C1a): sc-81290

HoxA7 Antibody (743C1a) is a mouse monoclonal IgG1 antibody that detects HoxA7 protein of human origin by western blotting (WB) and immunoprecipitation (IP). Anti-HoxA7 antibody (743C1a) is available as non-conjugated format, providing researchers with a reliable tool for studying this critical protein. HoxA7 is a member of the homeobox gene family, which plays a vital role in regulating gene expression during embryonic development and is essential for proper formation of various structures, including central nervous system, limbs, and organs. HoxA7 functions as a transcriptional repressor, influencing expression of downstream target genes necessary for cell differentiation and organogenesis. HoxA7 activity is crucial for maintaining balance between cell proliferation and differentiation, which is particularly important in developmental biology and cancer research. HoxA7 is expressed in several tissues, including fetal liver, lung, skeletal muscle, kidney, pancreas, and placenta, highlighting significance in both developmental processes and potential implications in tumorigenesis. Understanding HoxA7 role and interactions with other proteins can provide insights into mechanisms underlying various developmental disorders and cancers, making HoxA7 (743C1a) antibody an invaluable research tool.

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HoxA7 Antibody (743C1a) References:

1. Differential expression of Hoxa-2 protein along the dorsal-ventral axis of the developing and adult mouse spinal cord.  |  Hao, Z., et al. 1999. Dev Dyn. 216: 201-17. PMID: 10536059
2. Temporal and spatial expression of Hoxa-2 during murine palatogenesis.  |  Nazarali, A., et al. 2000. Cell Mol Neurobiol. 20: 269-90. PMID: 10789828
3. Sequence analysis and tissue specific expression of human HOXA7.  |  Kim, MH., et al. 2000. Mol Biotechnol. 14: 19-24. PMID: 10911612
4. Molecular cloning and analysis of a group of genes differentially expressed in cells which overexpress the Hoxa-1 homeobox gene.  |  Shen, J., et al. 2000. Exp Cell Res. 259: 274-83. PMID: 10942599
5. Human HOX gene mutations.  |  Goodman, FR. and Scambler, PJ. 2001. Clin Genet. 59: 1-11. PMID: 11206481
6. HOXA7 stimulates human hepatocellular carcinoma proliferation through cyclin E1/CDK2.  |  Li, Y., et al. 2015. Oncol Rep. 33: 990-6. PMID: 25501982
7. HOXA7, HOXA9, and HOXA10 are differentially expressed in clival and sacral chordomas.  |  Jäger, D., et al. 2017. Sci Rep. 7: 2032. PMID: 28515451
8. HOXA7 promotes the metastasis of KRAS mutant colorectal cancer by regulating myeloid-derived suppressor cells.  |  Dang, Y., et al. 2022. Cancer Cell Int. 22: 88. PMID: 35183163
9. miR-17-5p/HOXA7 Is a Potential Driver for Brain Metastasis of Lung Adenocarcinoma Related to Ferroptosis Revealed by Bioinformatic Analysis.  |  Chen, Q., et al. 2022. Front Neurol. 13: 878947. PMID: 35693013
10. Magnesium-containing bioceramics stimulate exosomal miR-196a-5p secretion to promote senescent osteogenesis through targeting Hoxa7/MAPK signaling axis.  |  Qi, L., et al. 2024. Bioact Mater. 33: 14-29. PMID: 38024235
11. Repression by HoxA7 is mediated by the homeodomain and the modulatory action of its N-terminal-arm residues.  |  Schnabel, CA. and Abate-Shen, C. 1996. Mol Cell Biol. 16: 2678-88. PMID: 8649375
12. Expression of Hoxa-1 and Hoxb-7 is regulated by extracellular matrix-dependent signals in mammary epithelial cells.  |  Srebrow, A., et al. 1998. J Cell Biochem. 69: 377-91. PMID: 9620166

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-HoxA7 Antibody (743C1a) has 5 citations in a variety of scientific publications.

Primary antibodies like Anti-HoxA7 Antibody (743C1a) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

HoxA7 Antibody (743C1a) Specifications

Alternate Product Name: HoxA7

Product Clone Name: 743C1a

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁

Amino Acids:

Epitope Target: HoxA7

Epitope Species: human

Product Reactivity/Detection: HoxA7

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP

Vialing Information: Each vial contains 100 µg IgG₁ in 1.0 ml of PBS with < 0.1% sodium azide and 1.0% stabilizer protein

Research Citations: 5 citations in various scientific publications

Available Conjugates/Forms for HoxA7 Antibody (743C1a): N/A