HOOK3 Activators
Hook Microtubule Tethering Protein 3 (HOOK3) is a protein encoded by the HOOK3 gene in humans. As part of the Hook family of proteins, which also includes HOOK1 and HOOK2, HOOK3 interacts with microtubules, the structural components of the cell that help maintain its shape and play crucial roles in cell division, intracellular transport, and motility.HOOK3 is involved in tethering and transportation of intracellular organelles and vesicles. It plays a key role in maintaining the Golgi apparatus structure by tethering this organelle to microtubules. The Golgi apparatus is responsible for modifying, sorting, and packaging proteins and lipids for transport within the cell.
Additionally, HOOK3 is involved in the endocytic pathway, which is the process by which cells internalize molecules from their surface. This is achieved through the formation of vesicles that bud inward from the plasma membrane, a process in which HOOK3 is thought to participate.Abnormalities in HOOK3 function can lead to disruptions in intracellular transport and organelle function, potentially contributing to various cellular dysfunctions and diseases. For instance, mutations in HOOK3 have been implicated in certain neurodegenerative diseases.In summary, HOOK3 is a microtubule-tethering protein with important roles in maintaining cellular structure and facilitating intracellular transport.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Retinoic Acid, all trans | 302-79-4 | sc-200898 sc-200898A sc-200898B sc-200898C | 500 mg 5 g 10 g 100 g | $66.00 $325.00 $587.00 $1018.00 | 28 | |
Retinoic acid can modulate gene expression through its interaction with retinoic acid receptors, which may affect HOOK3 expression. | ||||||
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin activates adenylyl cyclase, increasing cAMP levels, which could influence HOOK3 expression by modulating cellular signaling pathways. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $152.00 $479.00 $632.00 $1223.00 $2132.00 | 33 | |
As a histone deacetylase inhibitor, Trichostatin A can alter chromatin structure, potentially increasing the accessibility of the HOOK3 gene to transcription factors. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
This compound is a DNA methyltransferase inhibitor, which could lead to the demethylation and possible upregulation of the HOOK3 gene. | ||||||
(−)-Epigallocatechin Gallate | 989-51-5 | sc-200802 sc-200802A sc-200802B sc-200802C sc-200802D sc-200802E | 10 mg 50 mg 100 mg 500 mg 1 g 10 g | $43.00 $73.00 $126.00 $243.00 $530.00 $1259.00 | 11 | |
A polyphenol found in green tea that may influence gene expression through its effects on cellular signaling and epigenetic modifications. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Lithium affects glycogen synthase kinase-3 activity, which is involved in various signaling pathways that could upregulate HOOK3 expression. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $31.00 $47.00 $84.00 $222.00 | 19 | |
Sodium butyrate acts as a histone deacetylase inhibitor and may increase the expression of genes by altering chromatin structure. | ||||||
Mifepristone | 84371-65-3 | sc-203134 | 100 mg | $61.00 | 17 | |
Mifepristone modulates glucocorticoid and progesterone receptor activity, which can affect transcriptional regulation of various genes. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Resveratrol influences sirtuin activity and may affect gene expression through pathways related to longevity and stress resistance. | ||||||
D,L-Sulforaphane | 4478-93-7 | sc-207495A sc-207495B sc-207495C sc-207495 sc-207495E sc-207495D | 5 mg 10 mg 25 mg 1 g 10 g 250 mg | $153.00 $292.00 $489.00 $1325.00 $8465.00 $933.00 | 22 | |
Sulforaphane affects transcription factors such as NRF2, which can lead to the induction of gene expression in response to oxidative stress. | ||||||