hnRNP M Inhibitors
The chemical class known as hnRNP M inhibitors encompasses a diverse array of compounds that intricately modulate the activity of heterogeneous nuclear ribonucleoprotein M (hnRNP M). These chemicals, through direct or indirect mechanisms, contribute to the inhibition of hnRNP M, unveiling avenues for research into the regulation of this RNA-binding protein. Pladienolide B and meayamycin B are spliceosome inhibitors that indirectly inhibit hnRNP M by disrupting the RNA splicing process, in which hnRNP M plays a crucial role. E7107 is a spliceosome modulator that indirectly modulates hnRNP M by impacting pre-mRNA splicing dynamics. TG003, a CDK7 inhibitor, directly inhibits hnRNP M by interfering with RNA polymerase II-mediated transcription, a process intricately connected to hnRNP M's function. Plumbagin, rocaglamide, and 5-fluorouracil modulate hnRNP M through various mechanisms. Plumbagin affects hnRNP M as part of its broader impact on cellular function, inducing oxidative stress and affecting the cell cycle. Rocaglamide indirectly inhibits hnRNP M by disrupting translation initiation processes. 5-Fluorouracil directly inhibits hnRNP M by interfering with nucleic acid synthesis.
Trifluoperazine and camptothecin exert their inhibitory effects on hnRNP M through distinct mechanisms. Trifluoperazine modulates calcium signaling, impacting hnRNP M's sensitivity to changes in calcium levels. Camptothecin, a topoisomerase I inhibitor, indirectly inhibits hnRNP M by affecting RNA-DNA interactions through alterations in DNA topology. Flavopiridol and cucurbitacin I directly or indirectly inhibit hnRNP M by affecting cell cycle progression and cellular processes related to inflammation and proliferation, in which hnRNP M is involved. Triptolide, another natural product, modulates hnRNP M through its broad effects on cellular processes, including transcription and translation. This repertoire of chemical inhibitors provides a valuable toolkit for researchers investigating the intricate regulation of hnRNP M. Their specific actions on various cellular pathways and processes offer insights into the diverse strategies for modulating hnRNP M activity, providing avenues for further exploration and understanding of this RNA-binding protein's role in cellular function.
SEE ALSO...
| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Pladienolide B | 445493-23-2 | sc-391691 sc-391691B sc-391691A sc-391691C sc-391691D sc-391691E | 0.5 mg 10 mg 20 mg 50 mg 100 mg 5 mg | $290.00 $5572.00 $10815.00 $25000.00 $65000.00 $2781.00 | 63 | |
Pladienolide B is a spliceosome inhibitor that affects the splicing machinery. hnRNP M is involved in RNA splicing, and inhibition of the spliceosome by pladienolide B can indirectly impact hnRNP M function by disrupting the splicing process that hnRNP M participates in. | ||||||
Cdc2-Like Kinase Inhibitor, TG003 | 300801-52-9 | sc-202528 sc-202528A | 5 mg 25 mg | $136.00 $537.00 | 6 | |
TG003 is a CDK7 inhibitor that affects RNA polymerase II-mediated transcription. hnRNP M is involved in transcriptional regulation, and the inhibition of CDK7 by TG003 can modulate the transcriptional activity of hnRNP M, providing a direct means of inhibiting hnRNP M function through interference with its transcriptional regulatory roles. | ||||||
Plumbagin | 481-42-5 | sc-253283 sc-253283A | 100 mg 250 mg | $51.00 $61.00 | 6 | |
Plumbagin is a compound with anti-tumor properties that can modulate various cellular processes. Its impact on the cell cycle and induction of oxidative stress can indirectly influence hnRNP M, as hnRNP M is involved in cellular processes related to proliferation and stress response. The inhibition of hnRNP M by plumbagin occurs as a consequence of its broader effects on cellular function. | ||||||
Rocaglamide | 84573-16-0 | sc-203241 sc-203241A sc-203241B sc-203241C sc-203241D | 100 µg 1 mg 5 mg 10 mg 25 mg | $270.00 $465.00 $1607.00 $2448.00 $5239.00 | 4 | |
Rocaglamide is a natural product that inhibits translation initiation. hnRNP M, involved in RNA metabolism, can be indirectly inhibited by rocaglamide through its impact on translation initiation processes. The disruption of translation initiation by rocaglamide represents an indirect mechanism by which hnRNP M function can be modulated. | ||||||
Fluorouracil | 51-21-8 | sc-29060 sc-29060A | 1 g 5 g | $36.00 $149.00 | 11 | |
Fluorouracil is an antimetabolite that interferes with nucleic acid synthesis. Its incorporation into RNA can disrupt RNA processing, affecting hnRNP M function. The inhibition of hnRNP M by 5-fluorouracil occurs as a consequence of altered RNA metabolism, representing a direct mechanism by which this compound modulates hnRNP M activity at the post-transcriptional level. | ||||||
Trifluoperazine Dihydrochloride | 440-17-5 | sc-201498 sc-201498A | 1 g 5 g | $56.00 $99.00 | 9 | |
Trifluoperazine is an antipsychotic drug that modulates calcium signaling. hnRNP M is sensitive to changes in calcium levels, and the modulation of calcium signaling by trifluoperazine can impact hnRNP M function. The inhibition of hnRNP M by trifluoperazine occurs as a consequence of altered calcium-mediated signaling pathways, presenting an indirect mechanism of hnRNP M modulation. | ||||||
Camptothecin | 7689-03-4 | sc-200871 sc-200871A sc-200871B | 50 mg 250 mg 100 mg | $57.00 $182.00 $92.00 | 21 | |
Camptothecin is a topoisomerase I inhibitor that affects DNA topology. hnRNP M, involved in RNA-DNA interactions, can be indirectly inhibited by camptothecin through its impact on topoisomerase I activity. The disruption of RNA-DNA interactions by camptothecin represents an indirect mechanism by which hnRNP M function can be modulated through alterations in DNA topology. | ||||||
Flavopiridol Hydrochloride | 131740-09-5 | sc-207687 | 10 mg | $311.00 | ||
Flavopiridol is a CDK inhibitor that affects cell cycle progression. hnRNP M is involved in cell cycle regulation, and the inhibition of CDKs by flavopiridol can modulate the cell cycle dynamics in which hnRNP M participates. The modulation of hnRNP M function by flavopiridol occurs as a consequence of altered cell cycle progression, providing a direct means of inhibiting hnRNP M. | ||||||
Cucurbitacin I | 2222-07-3 | sc-203010 | 1 mg | $250.00 | 9 | |
Cucurbitacin I is a natural product with anti-inflammatory and anti-tumor properties. Its impact on cellular processes related to inflammation and proliferation can indirectly influence hnRNP M, as hnRNP M is involved in these processes. The inhibition of hnRNP M by cucurbitacin I occurs as a consequence of its broader effects on cellular function, representing an indirect mechanism of hnRNP M modulation. | ||||||
Triptolide | 38748-32-2 | sc-200122 sc-200122A | 1 mg 5 mg | $88.00 $200.00 | 13 | |
Triptolide is a natural product with anti-inflammatory and anti-tumor properties. Its impact on various cellular processes, including transcription and translation, can indirectly influence hnRNP M, as hnRNP M is involved in RNA metabolism. The inhibition of hnRNP M by triptolide occurs as a consequence of its broader effects on cellular function, representing an indirect mechanism of hnRNP M modulation | ||||||