hnRNP M Antibody (A-12): sc-515008

hnRNP M Antibody (A-12) is a mouse monoclonal IgM antibody that detects hnRNP M of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). anti-hnRNP M antibody (A-12) is available as a non-conjugated format. Heterogeneous nuclear ribonucleoprotein M (hnRNP M) plays a crucial role in pre-mRNA splicing regulation, essential for proper mRNA transcript processing. hnRNP M (A-12) antibody targets a protein primarily located in the nucleus, where hnRNP M associates with pre-mRNA and influences splicing by interacting with various spliceosomal components. hnRNP M modulates splicing particularly during cellular stress, leading to transient splicing arrest that affects gene expression and cellular responses. hnRNP M also interacts with other proteins involved in RNA metabolism, highlighting its significance in post-transcriptional regulation. With versatile applications in western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA), anti-hnRNP M antibody (A-12) serves as an invaluable tool for studying RNA processing and gene regulation mechanisms in various biological contexts.

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hnRNP M Antibody (A-12) References:

1. Nuclear pre-mRNA compartmentalization: trafficking of released transcripts to splicing factor reservoirs.  |  Melcák, I., et al. 2000. Mol Biol Cell. 11: 497-510. PMID: 10679009
2. Protein-protein interaction among hnRNPs shuttling between nucleus and cytoplasm.  |  Kim, JH., et al. 2000. J Mol Biol. 298: 395-405. PMID: 10772858
3. Spatiotemporal regulation of hnRNP M and 2H9 gene expression during mouse embryonic development.  |  Mahé, D., et al. 2000. Biochim Biophys Acta. 1492: 414-24. PMID: 11004512
4. Direct interaction between hnRNP-M and CDC5L/PLRG1 proteins affects alternative splice site choice.  |  Llères, D., et al. 2010. EMBO Rep. 11: 445-51. PMID: 20467437
5. hnRNPM induces translation switch under hypoxia to promote colon cancer development.  |  Chen, TM., et al. 2019. EBioMedicine. 41: 299-309. PMID: 30852162
6. The heterogeneous nuclear ribonucleoprotein hnRNPM inhibits RNA virus-triggered innate immunity by antagonizing RNA sensing of RIG-I-like receptors.  |  Cao, P., et al. 2019. PLoS Pathog. 15: e1007983. PMID: 31433824
7. CDR1as regulated by hnRNPM maintains stemness of periodontal ligament stem cells via miR-7/KLF4.  |  Gu, X., et al. 2021. J Cell Mol Med. 25: 4501-4515. PMID: 33837664
8. Downregulation of HNRNPM inhibits cell proliferation and migration of hepatocellular carcinoma through MAPK/AKT signaling pathway.  |  Qiao, L., et al. 2022. Transl Cancer Res. 11: 2135-2144. PMID: 35966311
9. A nuclear localization domain in the hnRNP A1 protein.  |  Siomi, H. and Dreyfuss, G. 1995. J Cell Biol. 129: 551-60. PMID: 7730395
10. Identification and characterisation of a novel human RNA-binding protein.  |  Badolato, J., et al. 1995. Gene. 166: 323-7. PMID: 8543184
11. The human hnRNP-M proteins: structure and relation with early heat shock-induced splicing arrest and chromosome mapping.  |  Gattoni, R., et al. 1996. Nucleic Acids Res. 24: 2535-42. PMID: 8692693
12. mRNA silencing in erythroid differentiation: hnRNP K and hnRNP E1 regulate 15-lipoxygenase translation from the 3' end.  |  Ostareck, DH., et al. 1997. Cell. 89: 597-606. PMID: 9160751

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-hnRNP M Antibody (A-12) has 2 citations in a variety of scientific publications.

Primary antibodies like Anti-hnRNP M Antibody (A-12) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

hnRNP M Antibody (A-12) Specifications

Alternate Product Name: hnRNP M

Product Clone Name: A-12

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgM kappa light chain

Amino Acids: 396-592

Epitope Target: hnRNP M

Epitope Species: human

Product Reactivity/Detection: hnRNP M

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgM kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 2 citations in various scientific publications

Available Conjugates/Forms for hnRNP M Antibody (A-12): N/A

The preferred hnRNP M1-4 antibody is hnRNP M1-4 Antibody (1D8): sc-20002.