Cucurbitacin I (CAS 2222-07-3)
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Cucurbitacin I, Cucumis sativus L. has been found to suppress levels of phosphotyrosine Stat3 (signal transducer and activator of transcription 3) in v-Src-transformed NIH 3T3 cells. These transcription factors have been known to mediate a wide variety of biological functions in the peripheral and central nervous systems. Their inhibition can result in the suppression of Stat3 DNA binding and Stat3-mediated gene transcription. Additionally this compound has been found to reduce in vitro clonogenicity of certain cancer cells. The anti-proliferation activity of this compound is also related to its downregulating activity against Stat3 target gene expression. Hyperactivation of the JAK2 (Janus-activated kinase 2) has been reported to be responsible for abnormal dendritic cell differentiation. The blocking of this kinase by Curcurbitacin I could potentially stop abnormal dendrite cell differentiation and promote differentiation of mature macrophages and dendritic cells. Cucurbitacin I, Cucumis sativus L. is an inhibitor of JAK2.
Cucurbitacin I (CAS 2222-07-3) References
- Discovery of JSI-124 (cucurbitacin I), a selective Janus kinase/signal transducer and activator of transcription 3 signaling pathway inhibitor with potent antitumor activity against human and murine cancer cells in mice. | Blaskovich, MA., et al. 2003. Cancer Res. 63: 1270-9. PMID: 12649187
- Regulation of dendritic cell differentiation and antitumor immune response in cancer by pharmacologic-selective inhibition of the janus-activated kinase 2/signal transducers and activators of transcription 3 pathway. | Nefedova, Y., et al. 2005. Cancer Res. 65: 9525-35. PMID: 16230418
- Role of signal transducer and activator of transcription 3 in neuronal survival and regeneration. | Dziennis, S. and Alkayed, NJ. 2008. Rev Neurosci. 19: 341-61. PMID: 19145989
- Cucurbitacin I elicits anoikis sensitization, inhibits cellular invasion and in vivo tumor formation ability of nasopharyngeal carcinoma cells. | Lui, VW., et al. 2009. Carcinogenesis. 30: 2085-94. PMID: 19843642
- Cucurbitacin I inhibits cell motility by indirectly interfering with actin dynamics. | Knecht, DA., et al. 2010. PLoS One. 5: e14039. PMID: 21124831
- Cucurbitacin I inhibits Rac1 activation in breast cancer cells by a reactive oxygen species-mediated mechanism and independently of Janus tyrosine kinase 2 and P-Rex1. | Lopez-Haber, C. and Kazanietz, MG. 2013. Mol Pharmacol. 83: 1141-54. PMID: 23478800
- Cucurbitacin B and cucurbitacin I suppress adipocyte differentiation through inhibition of STAT3 signaling. | Seo, CR., et al. 2014. Food Chem Toxicol. 64: 217-24. PMID: 24316209
- Cucurbitacin I induces pro-death autophagy in A549 cells via the ERK-mTOR-STAT3 signaling pathway. | Ni, Y., et al. 2018. J Cell Biochem. 119: 6104-6112. PMID: 29575175
- Cucurbitacin I induces cancer cell death through the endoplasmic reticulum stress pathway. | Li, H., et al. 2019. J Cell Biochem. 120: 2391-2403. PMID: 30277611
- Cucurbitacin I Reverses Tumor-Associated Macrophage Polarization to Affect Cancer Cell Metastasis. | Gong, X., et al. 2023. Int J Mol Sci. 24: PMID: 37958903
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Cucurbitacin I, 1 mg | sc-203010 | 1 mg | $250.00 |