Date published: 2025-12-16

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HMG CRISPR Plasmids

Santa Cruz Biotechnology, Inc. offers a broad range of gene editing products including CRISPR/Cas9 Knockout and CRISPR Double Nickase plasmids for gene silencing. HMG gene silencers are available as HMG CRISPR/Cas9 Knockout plasmids and HMG Double Nickase Plasmids. HMG CRISPR/dCas9 Activation Plasmids and CRISPR Lenti Activation Systems for gene activation are also available. Gene silencers and activators are useful for gene studies in combination with antibodies used for protein detection.

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HMG CRISPR Knockout, HDR and Double Nickase Plasmids

Empty Table HeaderProduct NameCATALOG #SpeciesAPPLICATIONSMARKERCitationsRATING

HMG-I/HMG-Y CRISPR/Cas9 KO Plasmid (h)

sc-402396hGene KnockoutGFP0
(0)

HMG-I/HMG-Y HDR Plasmid (h)

sc-402396-HDRhHomology Directed RepairPuromycin0
(0)

HMG-I/HMG-Y Double Nickase Plasmid (h)

sc-402396-NIChGene KnockoutPuromycin0
(0)

HMG-I/HMG-Y Double Nickase Plasmid (h2)

sc-402396-NIC-2hGene KnockoutPuromycin0
(0)

HMG-I/HMG-Y CRISPR/Cas9 KO Plasmid (m2)

sc-420879-KO-2mGene KnockoutGFP0
(0)

HMG-I/HMG-Y HDR Plasmid (m2)

sc-420879-HDR-2mHomology Directed RepairPuromycin0
(0)

HMG-I/HMG-Y Double Nickase Plasmid (m)

sc-420879-NICmGene KnockoutPuromycin0
(0)

HMG-I/HMG-Y Double Nickase Plasmid (m2)

sc-420879-NIC-2mGene KnockoutPuromycin0
(0)

HMGI-C CRISPR/Cas9 KO Plasmid (h)

sc-401573hGene KnockoutGFP0
(0)

HMGI-C HDR Plasmid (h)

sc-401573-HDRhHomology Directed RepairPuromycin0
(0)

HMGI-C Double Nickase Plasmid (h)

sc-401573-NIChGene KnockoutPuromycin0
(0)

HMGI-C Double Nickase Plasmid (h2)

sc-401573-NIC-2hGene KnockoutPuromycin0
(0)

HMGI-C CRISPR/Cas9 KO Plasmid (m)

sc-420880mGene KnockoutGFP
1
(0)

HMGI-C HDR Plasmid (m)

sc-420880-HDRmHomology Directed RepairPuromycin
1
(0)

HMGI-C Double Nickase Plasmid (m)

sc-420880-NICmGene KnockoutPuromycin
1
(0)

HMGI-C Double Nickase Plasmid (m2)

sc-420880-NIC-2mGene KnockoutPuromycin
1
(0)

HMG-4 CRISPR/Cas9 KO Plasmid (h)

sc-414303hGene KnockoutGFP0
(0)

HMG-4 HDR Plasmid (h)

sc-414303-HDRhHomology Directed RepairPuromycin0
(0)

HMG-4 Double Nickase Plasmid (h)

sc-414303-NIChGene KnockoutPuromycin0
(0)

HMG-4 Double Nickase Plasmid (h2)

sc-414303-NIC-2hGene KnockoutPuromycin0
(0)

HMG-4 CRISPR/Cas9 KO Plasmid (m)

sc-427375mGene KnockoutGFP0
(0)

HMG-4 HDR Plasmid (m)

sc-427375-HDRmHomology Directed RepairPuromycin0
(0)

HMG-4 Double Nickase Plasmid (m)

sc-427375-NICmGene KnockoutPuromycin0
(0)

HMG-4 Double Nickase Plasmid (m2)

sc-427375-NIC-2mGene KnockoutPuromycin0
(0)

HMG-1/HMGB1 CRISPR/Cas9 KO Plasmid (h)

sc-400735hGene KnockoutGFP
1
(0)

HMG-1/HMGB1 HDR Plasmid (h)

sc-400735-HDRhHomology Directed RepairPuromycin
1
(0)

HMG-1/HMGB1 Double Nickase Plasmid (h)

sc-400735-NIChGene KnockoutPuromycin
1
(0)

HMG-1/HMGB1 Double Nickase Plasmid (h2)

sc-400735-NIC-2hGene KnockoutPuromycin
1
(0)

HMG-1/HMGB1 CRISPR/Cas9 KO Plasmid (m2)

sc-420871-KO-2mGene KnockoutGFP
1
(0)

HMG-1/HMGB1 HDR Plasmid (m2)

sc-420871-HDR-2mHomology Directed RepairPuromycin
1
(0)

HMG-1/HMGB1 Double Nickase Plasmid (m)

sc-420871-NICmGene KnockoutPuromycin
1
(0)

HMG-1/HMGB1 Double Nickase Plasmid (m2)

sc-420871-NIC-2mGene KnockoutPuromycin
1
(0)

HMG-14 CRISPR/Cas9 KO Plasmid (h)

sc-416537hGene KnockoutGFP0
(0)

HMG-14 HDR Plasmid (h)

sc-416537-HDRhHomology Directed RepairPuromycin0
(0)

HMG-14 Double Nickase Plasmid (h)

sc-416537-NIChGene KnockoutPuromycin0
(0)

HMG-14 Double Nickase Plasmid (h2)

sc-416537-NIC-2hGene KnockoutPuromycin0
(0)

HMG-14 CRISPR/Cas9 KO Plasmid (m)

sc-420872mGene KnockoutGFP0
(0)

HMG-14 HDR Plasmid (m)

sc-420872-HDRmHomology Directed RepairPuromycin0
(0)

HMG-14 Double Nickase Plasmid (m)

sc-420872-NICmGene KnockoutPuromycin0
(0)

HMG-14 Double Nickase Plasmid (m2)

sc-420872-NIC-2mGene KnockoutPuromycin0
(0)

HMG-17 CRISPR/Cas9 KO Plasmid (h)

sc-407458hGene KnockoutGFP0
(0)

HMG-17 HDR Plasmid (h)

sc-407458-HDRhHomology Directed RepairPuromycin0
(0)

HMG-17 Double Nickase Plasmid (h)

sc-407458-NIChGene KnockoutPuromycin0
(0)

HMG-17 Double Nickase Plasmid (h2)

sc-407458-NIC-2hGene KnockoutPuromycin0
(0)

HMG-17 CRISPR/Cas9 KO Plasmid (m)

sc-420873mGene KnockoutGFP0
(0)

HMG-17 HDR Plasmid (m)

sc-420873-HDRmHomology Directed RepairPuromycin0
(0)

HMG-17 Double Nickase Plasmid (m)

sc-420873-NICmGene KnockoutPuromycin0
(0)

HMG-17 Double Nickase Plasmid (m2)

sc-420873-NIC-2mGene KnockoutPuromycin0
(0)

HMG-20A CRISPR/Cas9 KO Plasmid (h)

sc-407302hGene KnockoutGFP0
(0)

HMG-20A Double Nickase Plasmid (h)

sc-407302-NIChGene KnockoutPuromycin0
(0)

HMG-20A Double Nickase Plasmid (h2)

sc-407302-NIC-2hGene KnockoutPuromycin0
(0)

HMG-20A CRISPR/Cas9 KO Plasmid (m)

sc-426235mGene KnockoutGFP0
(0)

HMG-20A HDR Plasmid (m)

sc-426235-HDRmHomology Directed RepairPuromycin0
(0)

HMG-20A Double Nickase Plasmid (m)

sc-426235-NICmGene KnockoutPuromycin0
(0)

HMG-20A Double Nickase Plasmid (m2)

sc-426235-NIC-2mGene KnockoutPuromycin0
(0)

HMG-2L1 CRISPR/Cas9 KO Plasmid (h)

sc-411407hGene KnockoutGFP0
(0)

HMG-2L1 HDR Plasmid (h)

sc-411407-HDRhHomology Directed RepairPuromycin0
(0)

HMG-2L1 Double Nickase Plasmid (h)

sc-411407-NIChGene KnockoutPuromycin0
(0)

HMG-2L1 Double Nickase Plasmid (h2)

sc-411407-NIC-2hGene KnockoutPuromycin0
(0)

HMG-2L1 CRISPR/Cas9 KO Plasmid (m)

sc-427812mGene KnockoutGFP0
(0)

HMG-2L1 HDR Plasmid (m)

sc-427812-HDRmHomology Directed RepairPuromycin0
(0)

HMG-2L1 Double Nickase Plasmid (m)

sc-427812-NICmGene KnockoutPuromycin0
(0)

HMG-2L1 Double Nickase Plasmid (m2)

sc-427812-NIC-2mGene KnockoutPuromycin0
(0)

HMG-2/HMGB2 CRISPR/Cas9 KO Plasmid (h)

sc-404000hGene KnockoutGFP0
(0)

HMG-2/HMGB2 HDR Plasmid (h)

sc-404000-HDRhHomology Directed RepairPuromycin0
(0)

HMG-2/HMGB2 Double Nickase Plasmid (h)

sc-404000-NIChGene KnockoutPuromycin0
(0)

HMG-2/HMGB2 Double Nickase Plasmid (h2)

sc-404000-NIC-2hGene KnockoutPuromycin0
(0)

HMG-2/HMGB2 CRISPR/Cas9 KO Plasmid (m)

sc-430174mGene KnockoutGFP0
(0)

HMG-2/HMGB2 HDR Plasmid (m)

sc-430174-HDRmHomology Directed RepairPuromycin0
(0)

HMG-2/HMGB2 Double Nickase Plasmid (m)

sc-430174-NICmGene KnockoutPuromycin0
(0)

HMG-2/HMGB2 Double Nickase Plasmid (m2)

sc-430174-NIC-2mGene KnockoutPuromycin0
(0)

HMG-3/HMGB3 CRISPR/Cas9 KO Plasmid (h)

sc-409629hGene KnockoutGFP0
(0)

HMG-3/HMGB3 HDR Plasmid (h)

sc-409629-HDRhHomology Directed RepairPuromycin0
(0)

HMG-3/HMGB3 Double Nickase Plasmid (h)

sc-409629-NIChGene KnockoutPuromycin0
(0)

HMG-3/HMGB3 Double Nickase Plasmid (h2)

sc-409629-NIC-2hGene KnockoutPuromycin0
(0)

HMG-3/HMGB3 CRISPR/Cas9 KO Plasmid (m)

sc-420875mGene KnockoutGFP0
(0)

HMG-3/HMGB3 CRISPR/Cas9 KO Plasmid (m2)

sc-420875-KO-2mGene KnockoutGFP0
(0)

HMG-3/HMGB3 HDR Plasmid (m2)

sc-420875-HDR-2mHomology Directed RepairPuromycin0
(0)

HMG-3/HMGB3 Double Nickase Plasmid (m)

sc-420875-NICmGene KnockoutPuromycin0
(0)

HMG-3/HMGB3 Double Nickase Plasmid (m2)

sc-420875-NIC-2mGene KnockoutPuromycin0
(0)

HMG CRISPR Activation Products

Empty Table HeaderProduct NameCATALOG #SpeciesAPPLICATIONSMARKERCitationsRATING

HMG-I/HMG-Y CRISPR Activation Plasmid (h)

sc-402396-ACThGene ActivationPuro, Blast, Hygro0
(0)

HMG-I/HMG-Y CRISPR Activation Plasmid (h2)

sc-402396-ACT-2hGene ActivationPuro, Blast, Hygro0
(0)

HMG-I/HMG-Y Lentiviral Activation Particles (h)

sc-402396-LAChGene ActivationPuro, Blast, Hygro0
(0)

HMG-I/HMG-Y Lentiviral Activation Particles (h2)

sc-402396-LAC-2hGene ActivationPuro, Blast, Hygro0
(0)

HMG-I/HMG-Y CRISPR Activation Plasmid (m)

sc-420879-ACTmGene ActivationPuro, Blast, Hygro0
(0)

HMG-I/HMG-Y CRISPR Activation Plasmid (m2)

sc-420879-ACT-2mGene ActivationPuro, Blast, Hygro0
(0)

HMG-I/HMG-Y Lentiviral Activation Particles (m)

sc-420879-LACmGene ActivationPuro, Blast, Hygro0
(0)

HMG-I/HMG-Y Lentiviral Activation Particles (m2)

sc-420879-LAC-2mGene ActivationPuro, Blast, Hygro0
(0)

HMGI-C CRISPR Activation Plasmid (h)

sc-401573-ACThGene ActivationPuro, Blast, Hygro0
(0)

HMGI-C CRISPR Activation Plasmid (h2)

sc-401573-ACT-2hGene ActivationPuro, Blast, Hygro0
(0)

HMGI-C Lentiviral Activation Particles (h)

sc-401573-LAChGene ActivationPuro, Blast, Hygro0
(0)

HMGI-C Lentiviral Activation Particles (h2)

sc-401573-LAC-2hGene ActivationPuro, Blast, Hygro0
(0)

HMGI-C CRISPR Activation Plasmid (m)

sc-420880-ACTmGene ActivationPuro, Blast, Hygro
1
(0)

HMGI-C CRISPR Activation Plasmid (m2)

sc-420880-ACT-2mGene ActivationPuro, Blast, Hygro
1
(0)

HMGI-C Lentiviral Activation Particles (m)

sc-420880-LACmGene ActivationPuro, Blast, Hygro
1
(0)

HMGI-C Lentiviral Activation Particles (m2)

sc-420880-LAC-2mGene ActivationPuro, Blast, Hygro
1
(0)

HMG-4 CRISPR Activation Plasmid (h)

sc-414303-ACThGene ActivationPuro, Blast, Hygro0
(0)

HMG-4 CRISPR Activation Plasmid (h2)

sc-414303-ACT-2hGene ActivationPuro, Blast, Hygro0
(0)

HMG-4 Lentiviral Activation Particles (h)

sc-414303-LAChGene ActivationPuro, Blast, Hygro0
(0)

HMG-4 Lentiviral Activation Particles (h2)

sc-414303-LAC-2hGene ActivationPuro, Blast, Hygro0
(0)

HMG-4 CRISPR Activation Plasmid (m)

sc-427375-ACTmGene ActivationPuro, Blast, Hygro0
(0)

HMG-4 CRISPR Activation Plasmid (m2)

sc-427375-ACT-2mGene ActivationPuro, Blast, Hygro0
(0)

HMG-4 Lentiviral Activation Particles (m)

sc-427375-LACmGene ActivationPuro, Blast, Hygro0
(0)

HMG-4 Lentiviral Activation Particles (m2)

sc-427375-LAC-2mGene ActivationPuro, Blast, Hygro0
(0)

HMG-1/HMGB1 CRISPR Activation Plasmid (h)

sc-400735-ACThGene ActivationPuro, Blast, Hygro
1
(0)

HMG-1/HMGB1 CRISPR Activation Plasmid (h2)

sc-400735-ACT-2hGene ActivationPuro, Blast, Hygro
1
(0)

HMG-1/HMGB1 Lentiviral Activation Particles (h)

sc-400735-LAChGene ActivationPuro, Blast, Hygro
1
(0)

HMG-1/HMGB1 Lentiviral Activation Particles (h2)

sc-400735-LAC-2hGene ActivationPuro, Blast, Hygro
1
(0)

HMG-1/HMGB1 CRISPR Activation Plasmid (m)

sc-420871-ACTmGene ActivationPuro, Blast, Hygro
1
(0)

HMG-1/HMGB1 CRISPR Activation Plasmid (m2)

sc-420871-ACT-2mGene ActivationPuro, Blast, Hygro
1
(0)

HMG-1/HMGB1 Lentiviral Activation Particles (m)

sc-420871-LACmGene ActivationPuro, Blast, Hygro
1
(0)

HMG-1/HMGB1 Lentiviral Activation Particles (m2)

sc-420871-LAC-2mGene ActivationPuro, Blast, Hygro
1
(0)

HMG-14 CRISPR Activation Plasmid (h)

sc-416537-ACThGene ActivationPuro, Blast, Hygro0
(0)

HMG-14 CRISPR Activation Plasmid (h2)

sc-416537-ACT-2hGene ActivationPuro, Blast, Hygro0
(0)

HMG-14 Lentiviral Activation Particles (h)

sc-416537-LAChGene ActivationPuro, Blast, Hygro0
(0)

HMG-14 Lentiviral Activation Particles (h2)

sc-416537-LAC-2hGene ActivationPuro, Blast, Hygro0
(0)

HMG-14 CRISPR Activation Plasmid (m)

sc-420872-ACTmGene ActivationPuro, Blast, Hygro0
(0)

HMG-14 CRISPR Activation Plasmid (m2)

sc-420872-ACT-2mGene ActivationPuro, Blast, Hygro0
(0)

HMG-14 Lentiviral Activation Particles (m)

sc-420872-LACmGene ActivationPuro, Blast, Hygro0
(0)

HMG-14 Lentiviral Activation Particles (m2)

sc-420872-LAC-2mGene ActivationPuro, Blast, Hygro0
(0)

HMG-17 CRISPR Activation Plasmid (h)

sc-407458-ACThGene ActivationPuro, Blast, Hygro0
(0)

HMG-17 CRISPR Activation Plasmid (h2)

sc-407458-ACT-2hGene ActivationPuro, Blast, Hygro0
(0)

HMG-17 Lentiviral Activation Particles (h)

sc-407458-LAChGene ActivationPuro, Blast, Hygro0
(0)

HMG-17 Lentiviral Activation Particles (h2)

sc-407458-LAC-2hGene ActivationPuro, Blast, Hygro0
(0)

HMG-17 CRISPR Activation Plasmid (m)

sc-420873-ACTmGene ActivationPuro, Blast, Hygro0
(0)

HMG-17 CRISPR Activation Plasmid (m2)

sc-420873-ACT-2mGene ActivationPuro, Blast, Hygro0
(0)

HMG-17 Lentiviral Activation Particles (m)

sc-420873-LACmGene ActivationPuro, Blast, Hygro0
(0)

HMG-17 Lentiviral Activation Particles (m2)

sc-420873-LAC-2mGene ActivationPuro, Blast, Hygro0
(0)

HMG-20A CRISPR Activation Plasmid (h)

sc-407302-ACThGene ActivationPuro, Blast, Hygro0
(0)

HMG-20A CRISPR Activation Plasmid (h2)

sc-407302-ACT-2hGene ActivationPuro, Blast, Hygro0
(0)

HMG-20A Lentiviral Activation Particles (h)

sc-407302-LAChGene ActivationPuro, Blast, Hygro0
(0)

HMG-20A Lentiviral Activation Particles (h2)

sc-407302-LAC-2hGene ActivationPuro, Blast, Hygro0
(0)

HMG-20A CRISPR Activation Plasmid (m)

sc-426235-ACTmGene ActivationPuro, Blast, Hygro0
(0)

HMG-20A CRISPR Activation Plasmid (m2)

sc-426235-ACT-2mGene ActivationPuro, Blast, Hygro0
(0)

HMG-20A Lentiviral Activation Particles (m)

sc-426235-LACmGene ActivationPuro, Blast, Hygro0
(0)

HMG-20A Lentiviral Activation Particles (m2)

sc-426235-LAC-2mGene ActivationPuro, Blast, Hygro0
(0)

HMG-2L1 CRISPR Activation Plasmid (h)

sc-411407-ACThGene ActivationPuro, Blast, Hygro0
(0)

HMG-2L1 CRISPR Activation Plasmid (h2)

sc-411407-ACT-2hGene ActivationPuro, Blast, Hygro0
(0)

HMG-2L1 Lentiviral Activation Particles (h)

sc-411407-LAChGene ActivationPuro, Blast, Hygro0
(0)

HMG-2L1 Lentiviral Activation Particles (h2)

sc-411407-LAC-2hGene ActivationPuro, Blast, Hygro0
(0)

HMG-2L1 CRISPR Activation Plasmid (m)

sc-427812-ACTmGene ActivationPuro, Blast, Hygro0
(0)

HMG-2L1 CRISPR Activation Plasmid (m2)

sc-427812-ACT-2mGene ActivationPuro, Blast, Hygro0
(0)

HMG-2L1 Lentiviral Activation Particles (m)

sc-427812-LACmGene ActivationPuro, Blast, Hygro0
(0)

HMG-2L1 Lentiviral Activation Particles (m2)

sc-427812-LAC-2mGene ActivationPuro, Blast, Hygro0
(0)

HMG-2/HMGB2 CRISPR Activation Plasmid (h)

sc-404000-ACThGene ActivationPuro, Blast, Hygro0
(0)

HMG-2/HMGB2 CRISPR Activation Plasmid (h2)

sc-404000-ACT-2hGene ActivationPuro, Blast, Hygro0
(0)

HMG-2/HMGB2 Lentiviral Activation Particles (h)

sc-404000-LAChGene ActivationPuro, Blast, Hygro0
(0)

HMG-2/HMGB2 Lentiviral Activation Particles (h2)

sc-404000-LAC-2hGene ActivationPuro, Blast, Hygro0
(0)

HMG-2/HMGB2 CRISPR Activation Plasmid (m)

sc-430174-ACTmGene ActivationPuro, Blast, Hygro0
(0)

HMG-2/HMGB2 CRISPR Activation Plasmid (m2)

sc-430174-ACT-2mGene ActivationPuro, Blast, Hygro0
(0)

HMG-2/HMGB2 Lentiviral Activation Particles (m)

sc-430174-LACmGene ActivationPuro, Blast, Hygro0
(0)

HMG-2/HMGB2 Lentiviral Activation Particles (m2)

sc-430174-LAC-2mGene ActivationPuro, Blast, Hygro0
(0)

HMG-3/HMGB3 CRISPR Activation Plasmid (h)

sc-409629-ACThGene ActivationPuro, Blast, Hygro0
(0)

HMG-3/HMGB3 CRISPR Activation Plasmid (h2)

sc-409629-ACT-2hGene ActivationPuro, Blast, Hygro0
(0)

HMG-3/HMGB3 Lentiviral Activation Particles (h)

sc-409629-LAChGene ActivationPuro, Blast, Hygro0
(0)

HMG-3/HMGB3 Lentiviral Activation Particles (h2)

sc-409629-LAC-2hGene ActivationPuro, Blast, Hygro0
(0)

HMG-3/HMGB3 CRISPR Activation Plasmid (m)

sc-420875-ACTmGene ActivationPuro, Blast, Hygro0
(0)

HMG-3/HMGB3 CRISPR Activation Plasmid (m2)

sc-420875-ACT-2mGene ActivationPuro, Blast, Hygro0
(0)

HMG-3/HMGB3 Lentiviral Activation Particles (m)

sc-420875-LACmGene ActivationPuro, Blast, Hygro0
(0)

HMG-3/HMGB3 Lentiviral Activation Particles (m2)

sc-420875-LAC-2mGene ActivationPuro, Blast, Hygro0
(0)