HLTF Inhibitors
HLTF inhibitors are chemical compounds that modulate the activity of the Helicase-Like Transcription Factor (HLTF) protein. HLTF is a multifunctional protein known for its roles in DNA repair, DNA replication, and chromatin remodeling. It belongs to the SWI/SNF family of ATP-dependent chromatin remodelers and is involved in the maintenance of genome stability. HLTF plays a critical part in several DNA repair pathways, such as the post-replication repair (PRR) and template switching mechanisms, contributing to the resolution of DNA lesions and the prevention of mutations. HLTF inhibitors serve as essential tools in molecular and cellular research, enabling scientists to investigate the functions of HLTF and its involvement in DNA repair and genome maintenance.
Researchers employ HLTF inhibitors to explore the specific roles of HLTF in DNA repair and replication processes. By selectively inhibiting HLTF, scientists can study its interactions with DNA substrates, its effects on the remodeling of nucleosomes, and its contributions to the fidelity of DNA synthesis and lesion bypass. This research provides insights into the molecular mechanisms underlying DNA repair pathways, chromatin remodeling, and the maintenance of genomic integrity. Additionally, the study of HLTF inhibitors has broader implications for understanding the intricate network of proteins and pathways involved in genome stability, offering valuable information for the field of DNA damage response and repair, as well as potential connections to diseases associated with DNA repair defects.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Triptolide | 38748-32-2 | sc-200122 sc-200122A | 1 mg 5 mg | $88.00 $200.00 | 13 | |
Inhibits transcription by affecting RNA polymerase II activity, which could indirectly reduce HLTF expression. | ||||||
Mithramycin A | 18378-89-7 | sc-200909 | 1 mg | $54.00 | 6 | |
Binds to G-C-rich DNA sequences and can inhibit transcription of certain genes, potentially including HLTF. | ||||||
Actinomycin D | 50-76-0 | sc-200906 sc-200906A sc-200906B sc-200906C sc-200906D | 5 mg 25 mg 100 mg 1 g 10 g | $73.00 $238.00 $717.00 $2522.00 $21420.00 | 53 | |
Binds to DNA and inhibits RNA polymerase, which may decrease transcription of genes like HLTF. | ||||||
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
A DNA methyltransferase inhibitor that can alter gene expression patterns, possibly affecting HLTF expression. | ||||||
Rifampicin | 13292-46-1 | sc-200910 sc-200910A sc-200910B sc-200910C | 1 g 5 g 100 g 250 g | $95.00 $322.00 $663.00 $1438.00 | 6 | |
Binds to RNA polymerase and inhibits RNA synthesis, potentially reducing HLTF mRNA levels. | ||||||
Chloroquine | 54-05-7 | sc-507304 | 250 mg | $68.00 | 2 | |
Known to intercalate in DNA, which can affect DNA replication and transcription processes, possibly reducing HLTF expression. | ||||||
Camptothecin | 7689-03-4 | sc-200871 sc-200871A sc-200871B | 50 mg 250 mg 100 mg | $57.00 $182.00 $92.00 | 21 | |
Inhibits DNA topoisomerase I, which is critical for DNA transcription and replication, potentially decreasing HLTF expression. | ||||||
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $149.00 $470.00 $620.00 $1199.00 $2090.00 | 33 | |
Histone deacetylase inhibitor that changes chromatin structure and gene expression, possibly lowering HLTF levels. | ||||||
Suberoylanilide Hydroxamic Acid | 149647-78-9 | sc-220139 sc-220139A | 100 mg 500 mg | $130.00 $270.00 | 37 | |
Another histone deacetylase inhibitor that can alter gene expression and might affect HLTF expression. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $30.00 $46.00 $82.00 $218.00 | 19 | |
Histone deacetylase inhibitor that induces hyperacetylation of histones and can modulate gene expression, potentially affecting HLTF. | ||||||