HIV-1 gp120 Activators
Chemical class HIV-1 gp120 Activators encompasses a diverse range of compounds that can indirectly influence the activity or expression of HIV-1 gp120, a glycoprotein essential for the HIV virus to bind to and enter host cells. These activators do not directly interact with gp120; instead, they modulate various cellular signaling pathways and transcriptional processes that can ultimately affect gp120.
The chemicals listed are primarily involved in regulating key signaling pathways like PKA, PKC, MAPK/ERK, Wnt/β-catenin, mTOR, NF-κB, and others. For instance, Forskolin, by elevating cAMP levels, influences the PKA signaling pathway, which can lead to changes in transcriptional regulation affecting gp120. Similarly, PMA, through the activation of PKC, may impact the protein's expression or processing via transcriptional changes. Others, like Lithium chloride and Rapamycin, modulate the Wnt/β-catenin and mTOR pathways, respectively, creating an environment where gp120's activity or expression might be altered.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Forskolin | 66575-29-9 | sc-3562 sc-3562A sc-3562B sc-3562C sc-3562D | 5 mg 50 mg 1 g 2 g 5 g | $78.00 $153.00 $740.00 $1413.00 $2091.00 | 73 | |
Forskolin activates adenylyl cyclase, increasing cAMP levels in cells. Elevated cAMP can modulate the PKA signaling pathway, which may affect HIV-1 gp120 expression or function indirectly through transcriptional regulation or post-translational modifications. | ||||||
PMA | 16561-29-8 | sc-3576 sc-3576A sc-3576B sc-3576C sc-3576D | 1 mg 5 mg 10 mg 25 mg 100 mg | $41.00 $132.00 $214.00 $500.00 $948.00 | 119 | |
PMA activates Protein Kinase C (PKC), which is involved in numerous signaling cascades. PKC activation can lead to changes in the transcriptional activity of factors that regulate HIV-1 gp120 expression or processing. | ||||||
Lithium | 7439-93-2 | sc-252954 | 50 g | $214.00 | ||
Lithium chloride inhibits glycogen synthase kinase-3 (GSK-3). Inhibition of GSK-3 can alter the Wnt/β-catenin signaling pathway, potentially influencing HIV-1 gp120 expression through transcriptional regulation. | ||||||
Rapamycin | 53123-88-9 | sc-3504 sc-3504A sc-3504B | 1 mg 5 mg 25 mg | $63.00 $158.00 $326.00 | 233 | |
Rapamycin inhibits the mTOR pathway, which is involved in cell growth and proliferation. This inhibition can lead to alterations in cellular conditions that might indirectly influence HIV-1 gp120 activity. | ||||||
Curcumin | 458-37-7 | sc-200509 sc-200509A sc-200509B sc-200509C sc-200509D sc-200509F sc-200509E | 1 g 5 g 25 g 100 g 250 g 1 kg 2.5 kg | $37.00 $69.00 $109.00 $218.00 $239.00 $879.00 $1968.00 | 47 | |
Curcumin can modulate multiple signaling pathways, including NF-κB, which is involved in inflammatory responses. Alteration in NF-κB activity may impact HIV-1 gp120 expression or function. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $31.00 $47.00 $84.00 $222.00 | 19 | |
Sodium butyrate is a histone deacetylase inhibitor, which can affect chromatin structure and gene expression. This may indirectly influence HIV-1 gp120 expression by altering the transcriptional landscape. | ||||||
Resveratrol | 501-36-0 | sc-200808 sc-200808A sc-200808B | 100 mg 500 mg 5 g | $80.00 $220.00 $460.00 | 64 | |
Resveratrol affects SIRT1, a sirtuin involved in histone deacetylation. By modulating SIRT1 activity, resveratrol can influence gene expression patterns, potentially affecting HIV-1 gp120 expression. | ||||||
SB 203580 | 152121-47-6 | sc-3533 sc-3533A | 1 mg 5 mg | $90.00 $349.00 | 284 | |
SB203580 is a p38 MAPK inhibitor. While primarily inhibitory, its modulation of the p38 MAPK pathway could indirectly influence other pathways that affect HIV-1 gp120 expression or activity. | ||||||
SP600125 | 129-56-6 | sc-200635 sc-200635A | 10 mg 50 mg | $40.00 $150.00 | 257 | |
SP600125 is a JNK inhibitor. By modulating JNK activity, it can affect transcription factors and cellular stress responses, potentially influencing HIV-1 gp120 expression. | ||||||
LY 294002 | 154447-36-6 | sc-201426 sc-201426A | 5 mg 25 mg | $123.00 $400.00 | 148 | |
LY294002 is a PI3K inhibitor. Though primarily an inhibitor, its effects on the PI3K/Akt pathway can indirectly affect other signaling pathways involved in HIV-1 gp120 expression. | ||||||