Histone cluster 2 H4 Inhibitors
Chemical inhibitors of Histone cluster 2 H4 work primarily by interfering with the histone deacetylase (HDAC) enzymes that modulate the acetylation state of this protein. Compounds like Trichostatin A, Vorinostat, Romidepsin, Belinostat, Panobinostat, Mocetinostat, Entinostat, Givinostat, and Chidamide are all known to inhibit HDAC activity. By doing so, these inhibitors prevent the deacetylation of Histone cluster 2 H4, which is a crucial process for the tight coiling of DNA around histones, a state that is generally associated with reduced gene expression. When Histone cluster 2 H4 remains acetylated due to the action of these inhibitors, the chromatin structure becomes relaxed, and this altered state can disrupt the normal function of Histone cluster 2 H4 in the regulation of gene expression by maintaining the chromatin in a transcriptionally active state.
Other compounds, such as Sodium Butyrate and Valproic Acid, also act as HDAC inhibitors but with a broader specificity. These chemicals contribute to the sustained acetylation of Histone cluster 2 H4 by inhibiting the enzymes that would typically remove acetyl groups. This inhibition results in a chromatin structure that remains in a more open and relaxed state, which can inhibit the normal compacting function of Histone cluster 2 H4.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $149.00 $470.00 $620.00 $1199.00 $2090.00 | 33 | |
Trichostatin A is an inhibitor of histone deacetylase (HDAC), an enzyme responsible for the deacetylation of Histone cluster 2 H4, which leads to the condensing of chromatin and suppression of gene expression. By inhibiting HDAC, Trichostatin A maintains acetylation of Histone cluster 2 H4, thus inhibiting its function. | ||||||
Suberoylanilide Hydroxamic Acid | 149647-78-9 | sc-220139 sc-220139A | 100 mg 500 mg | $130.00 $270.00 | 37 | |
Vorinostat, also known as SAHA, is an HDAC inhibitor that prevents the deacetylation of Histone cluster 2 H4. As histone deacetylation is crucial for the compact chromatin structure that represses gene expression, Vorinostat's action results in a more relaxed chromatin structure, inhibiting the normal function of Histone cluster 2 H4. | ||||||
Romidepsin | 128517-07-7 | sc-364603 sc-364603A | 1 mg 5 mg | $214.00 $622.00 | 1 | |
Romidepsin is a cyclic peptide that inhibits HDAC, leading to increased acetylation of Histone cluster 2 H4. This hyperacetylation disrupts the interaction between histones and DNA, leading to chromatin relaxation, which effectively inhibits the functional role of Histone cluster 2 H4 in gene silencing. | ||||||
Belinostat | 414864-00-9 | sc-269851 sc-269851A | 10 mg 100 mg | $153.00 $561.00 | ||
Belinostat is another HDAC inhibitor that increases the acetylation levels of Histone cluster 2 H4. By doing so, it disrupts the chromatin structure and prevents the histone from effectively compacting DNA, thereby inhibiting the histone's role in gene repression. | ||||||
Panobinostat | 404950-80-7 | sc-208148 | 10 mg | $196.00 | 9 | |
Panobinostat is a potent HDAC inhibitor that hyperacetylates Histone cluster 2 H4. The hyperacetylated histones cannot compact DNA as effectively, which interferes with the histone’s ability to regulate gene expression, thereby inhibiting its normal function. | ||||||
Mocetinostat | 726169-73-9 | sc-364539 sc-364539B sc-364539A | 5 mg 10 mg 50 mg | $210.00 $242.00 $1434.00 | 2 | |
Mocetinostat selectively inhibits certain HDAC classes, which include enzymes that deacetylate Histone cluster 2 H4. The inhibition of HDAC activity by Mocetinostat results in the sustained acetylation of Histone cluster 2 H4, leading to an inhibition of its ability to condense chromatin. | ||||||
MS-275 | 209783-80-2 | sc-279455 sc-279455A sc-279455B | 1 mg 5 mg 25 mg | $24.00 $88.00 $208.00 | 24 | |
Entinostat is an HDAC inhibitor that targets specific classes of HDAC enzymes acting on Histone cluster 2 H4. The inhibition of deacetylase activity by Entinostat leads to the retention of acetyl groups on Histone cluster 2 H4, thereby inhibiting the histone's function in chromatin compaction. | ||||||
ITF2357 | 732302-99-7 | sc-364513 sc-364513A | 5 mg 50 mg | $340.00 $1950.00 | ||
Givinostat, an HDAC inhibitor, increases acetylation of Histone cluster 2 H4, which in turn inhibits its function by disrupting the normal chromatin structure, leading to a transcriptionally active state that opposes the gene-repressive function of Histone cluster 2 H4. | ||||||
Chidamide | 743420-02-2 | sc-364462 sc-364462A sc-364462B | 1 mg 5 mg 25 mg | $61.00 $245.00 $1173.00 | ||
Chidamide is an HDAC inhibitor that specifically increases the acetylation of histone proteins, including Histone cluster 2 H4. This sustained acetylation inhibits the ability of Histone cluster 2 H4 to participate in the formation of the condensed chromatin structure necessary for gene silencing. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $30.00 $46.00 $82.00 $218.00 | 19 | |
Sodium Butyrate acts as an HDAC inhibitor, leading to increased acetylation of Histone cluster 2 H4. This enforced acetylation state inhibits the normal role of Histone cluster 2 H4 in chromatin condensation and gene silencing by maintaining a relaxed chromatin state conducive to transcription. | ||||||