Histone cluster 2 H4 Activators
Histone H4 Activators are a collection of chemical compounds that serve to increase the functional activity of Histone H4 by targeting the acetylation process, which is a key post-translational modification affecting chromatin structure and gene expression. Trichostatin A, Vorinostat, and Romidepsin are histone deacetylase inhibitors that prevent the removal of acetyl groups from lysine residues on Histone H4, leading to a more relaxed chromatin state that facilitates transcriptional activation. Similarly, Scriptaid and Panobinostat enhance Histone H4's role in transcription by increasing its acetylation levels, which correlates with a more accessible chromatin configuration for transcription factors and other regulatory proteins. Sodium Butyrate and Valproic Acid function through similar mechanisms by inhibiting histone deacetylase enzymes, resulting in the accumulation of acetylated Histone H4 and promoting gene expression by allowing a looser DNA-histone interaction.
Furthermore, Nicotinamide's inhibition of sirtuin histone deacetylases and Entinostat's selective inhibition of HDACs both lead to increased acetylation of Histone H4, enhancing its ability to support an open chromatin structure essential for active transcription. Givinostat, Apicidin, and Belinostat also act as histone deacetylase inhibitors, further contributing to the increased acetylation state of Histone H4 and thereby supporting a transcriptionally permissive chromatin environment. Collectively, these Histone H4 Activators, through their targeted effects on histonemodification and chromatin remodeling, facilitate the enhancement of Histone H4-mediated gene expression without the need for upregulating its expression or direct activation.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
Trichostatin A | 58880-19-6 | sc-3511 sc-3511A sc-3511B sc-3511C sc-3511D | 1 mg 5 mg 10 mg 25 mg 50 mg | $149.00 $470.00 $620.00 $1199.00 $2090.00 | 33 | |
Trichostatin A is a histone deacetylase inhibitor that increases the acetylation of lysine residues on Histone H4, thereby enhancing chromatin relaxation and promoting transcriptional activation. | ||||||
Sodium Butyrate | 156-54-7 | sc-202341 sc-202341B sc-202341A sc-202341C | 250 mg 5 g 25 g 500 g | $30.00 $46.00 $82.00 $218.00 | 19 | |
Sodium Butyrate acts as a histone deacetylase inhibitor, leading to increased acetylation of Histone H4, which facilitates transcriptional activation by allowing a more open chromatin state. | ||||||
Suberoylanilide Hydroxamic Acid | 149647-78-9 | sc-220139 sc-220139A | 100 mg 500 mg | $130.00 $270.00 | 37 | |
Vorinostat, or SAHA, inhibits histone deacetylase activity, resulting in the accumulation of acetylated Histone H4, thus promoting an open chromatin structure conducive to transcriptional activation. | ||||||
Valproic Acid | 99-66-1 | sc-213144 | 10 g | $85.00 | 9 | |
Valproic Acid inhibits histone deacetylase, leading to enhanced acetylation of Histone H4, which directly correlates with an open chromatin configuration and increased transcriptional activity. | ||||||
Nicotinamide | 98-92-0 | sc-208096 sc-208096A sc-208096B sc-208096C | 100 g 250 g 1 kg 5 kg | $43.00 $65.00 $200.00 $815.00 | 6 | |
Nicotinamide inhibits sirtuin histone deacetylases, increasing the acetylation status of Histone H4 and enhancing transcriptional activation by promoting chromatin decondensation. | ||||||
Panobinostat | 404950-80-7 | sc-208148 | 10 mg | $196.00 | 9 | |
Panobinostat is a potent histone deacetylase inhibitor that leads to hyperacetylation of Histone H4, promoting chromatin expansion and facilitating transcriptional activation. | ||||||
Romidepsin | 128517-07-7 | sc-364603 sc-364603A | 1 mg 5 mg | $214.00 $622.00 | 1 | |
Romidepsin is a selective histone deacetylase inhibitor that increases acetylation levels of Histone H4, resulting in transcriptional activation through chromatin relaxation. | ||||||
Scriptaid | 287383-59-9 | sc-202807 sc-202807A | 1 mg 5 mg | $63.00 $179.00 | 11 | |
Scriptaid acts as a histone deacetylase inhibitor, enhancing acetylation of Histone H4, which is associated with a relaxed chromatin structure and increased gene expression. | ||||||
MS-275 | 209783-80-2 | sc-279455 sc-279455A sc-279455B | 1 mg 5 mg 25 mg | $24.00 $88.00 $208.00 | 24 | |
Entinostat is a selective HDAC inhibitor that causes an increase in acetylated Histone H4, leading to chromatin relaxation and facilitating transcriptional activation. | ||||||
Apicidin | 183506-66-3 | sc-202061 sc-202061A | 1 mg 5 mg | $108.00 $336.00 | 9 | |
Apicidin is a cyclic tetrapeptide histone deacetylase inhibitor that leads to the accumulation of acetylated Histone H4, which correlates with transcription activation and chromatin decondensation. | ||||||