Histone cluster 2 H3B Inhibitors
Histone cluster 2 H3B inhibitors constitute a specialized class of chemical compounds meticulously designed to modulate the activity of histone cluster 2 H3B proteins. H3B, also known as H3 histone family member B, is a type of histone protein found in humans and plays a pivotal role in chromatin structure and gene regulation. Chromatin is the complex structure formed by DNA and histones in the cell nucleus, serving as the packaging material for the genetic material. Histones like H3B contribute to the compaction and organization of DNA, crucial for the regulation of gene expression, DNA replication, and genome stability.
Typically, H3B inhibitors are composed of small molecules or chemical compounds specifically engineered to interact with H3B proteins, targeting either their active sites or allosteric sites. This interaction can lead to the modulation of H3B's behavior, potentially affecting its role in chromatin structure, gene expression, and DNA packaging. Researchers in the fields of molecular biology and pharmacology are dedicated to unraveling the molecular mechanisms and functions of histone cluster 2 H3B proteins within the context of chromatin dynamics, aiming to gain insights into the intricate processes that govern epigenetic regulation and genomic stability. The development of H3B inhibitors represents an ongoing and dynamic area of research, contributing significantly to our understanding of chromatin biology and its critical role in gene expression and various cellular processes.
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| Product Name | CAS # | Catalog # | QUANTITY | Price | Citations | RATING |
|---|---|---|---|---|---|---|
5-Azacytidine | 320-67-2 | sc-221003 | 500 mg | $280.00 | 4 | |
This cytidine analog can be incorporated into DNA and RNA, potentially affecting DNA methylation and RNA transcription, which may inhibit histone gene expression. | ||||||
5-Aza-2′-Deoxycytidine | 2353-33-5 | sc-202424 sc-202424A sc-202424B | 25 mg 100 mg 250 mg | $218.00 $322.00 $426.00 | 7 | |
A DNA methyltransferase inhibitor that can alter DNA methylation patterns, potentially downregulating the expression of certain genes including histones. | ||||||
Apicidin | 183506-66-3 | sc-202061 sc-202061A | 1 mg 5 mg | $110.00 $343.00 | 9 | |
As a histone deacetylase inhibitor, it can change the acetylation state of histones, possibly affecting their own gene expression. | ||||||
Histone Lysine Methyltransferase Inhibitor Inhibitor | 935693-62-2 (free base) | sc-202651 | 5 mg | $151.00 | 4 | |
A diazepin-quinazolin-amine derivative that inhibits G9a histone methyltransferase, possibly affecting histone methylation and gene expression. | ||||||
Romidepsin | 128517-07-7 | sc-364603 sc-364603A | 1 mg 5 mg | $218.00 $634.00 | 1 | |
A histone deacetylase inhibitor that changes acetylation patterns of histones, potentially influencing gene expression. | ||||||
Mithramycin A | 18378-89-7 | sc-200909 | 1 mg | $55.00 | 6 | |
It binds to DNA and alters the binding of transcription factors, potentially reducing the expression of specific genes including histones. | ||||||
Triptolide | 38748-32-2 | sc-200122 sc-200122A | 1 mg 5 mg | $90.00 $204.00 | 13 | |
A diterpene triepoxide that can inhibit transcriptional activity, potentially downregulating various genes, including those for histones. | ||||||
Rocaglamide | 84573-16-0 | sc-203241 sc-203241A sc-203241B sc-203241C sc-203241D | 100 µg 1 mg 5 mg 10 mg 25 mg | $275.00 $474.00 $1639.00 $2497.00 $5344.00 | 4 | |
A natural product that can inhibit translation initiation, potentially decreasing protein levels of various transcripts including histones. | ||||||
Chetomin | 1403-36-7 | sc-202535 sc-202535A | 1 mg 5 mg | $186.00 $674.00 | 10 | |
It disrupts the structure of the transcription factor hypoxia-inducible factor 1 (HIF-1), potentially affecting the expression of many genes. | ||||||
(±)-JQ1 | 1268524-69-1 | sc-472932 sc-472932A | 5 mg 25 mg | $231.00 $863.00 | 1 | |
Inhibits BET bromodomain proteins, potentially downregulating gene expression, including that of histone genes. | ||||||